Organizers:
Saghir Akhtar (Cardiff University, UK)
Michael Gait (MRC - LMB, UK)
Mark Gumbleton (Cardiff University, UK)
Arwyn Jones (Cardiff University, UK )
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Session 1
12:00 - 14:00 Arrival and registration with coffee/tea and welsh cakes
14:00 - 14:10 Opening remarks
Challenges to macromolecular drug delivery
Rudy Juliano (University of North Carolina , USA)
Endocytic and intracellular trafficking pathways: molecule and mechanisms
George Banting (University of Bristol, UK)
15:30 - 16:00 Coffee/tea break
Peptide-based nanoparticles for in vivo delivery of siRNA targeting Cyclin B1
Selected oral communication - Gilles Divita (CRBM-CNRS, France)
Nanoparticles oligonucleotide complexes for the treatment of EWS/Fli-1 expressing tumours in mice
Selected oral communication - Claude Paul Malvy (Paris-Sud University, France)
Transfection of retinal pigment epithelium with pegylated lipoplexes
Selected oral communication - Liesbeth Peeters (Ghent University, Belgium)
17:00 - 19:00 Cheese and wine reception / poster session
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Session 2
Mechanisms and therapeutic application of RNA interference
John J. Rossi (Beckman Research Institute, USA)
From mouse to monkey, on the way to man: systemic delivery of siRNAs and antagomirs
Muthiah Manoharan (Alnylam Pharmaceuticals, USA)
Combinatorial selection, delivery and anti-viral activity of backbone modified oligonucleotide aptamers against HIV RT
Selected oral communication - Varatharasa Thiviyanathan (University of Texas, USA)
Effects of temperature on intracellular distribution of cell-penetrating peptides
Selected oral communication - Marjan Maria Fretz (Welsh School of Pharmacy, UK)
10:30 - 11:05 Coffee/tea break
Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides
Bernard Lebleu (University of Montpellier, France)
Vascular tumour targeting: from the bench to the clinic
Dario Neri (Institute of Pharmaceutical Sciences, Switzerland)
Polymer anticancer drug conjugates as nanomedicines: from laboratory to clinic
Ruth Duncan (Cardiff University, UK)
Bridging the gap for PEGylated proteins
Steve Brocchini (University of London, UK)
Dendrimer based nano-containers/scaffolding for targeted diagnostics /therapies
Donald Tomalia (Dendritic NanoTechnologies Inc, USA)
15:30 - 16:00 Coffee/tea break
Technologies for gene delivery to cancer
Leonard Seymour (University of Oxford, UK)
Gene delivery by cationic lipids: in and out of an endosome
Dick Hoekstra (University Medical Center Groningen, Netherlands)
19:30 - 22:00 Meeting dinner
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Session 3
Engineered microbial proteins for vaccination therapy
Randall J. Mrsny (Trinity BioSystems, Inc., USA)
Real-time intracellular confocal particle tracking of particulate drug carriers
Justin Hanes (The Johns Hopkins University, USA)
10:20 - 10:50 Coffee/tea break
10:50 - 11:00 Poster prize presentation
Gene silencing therapeutics: lessons from the past, prospects for the future
Alan Gewirtz (University of Pennsylvania, USA)
Receptor-mediated internalization of chelator-PNA-peptide hybridization probes for radioimaging and magnetic resonance imaging of oncogene mRNAs in tumours
Eric Wickstrom (Thomas Jefferson University, USA)
12:20 - 12:30 Closing remarks and meeting close
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