Organizers:
Ben Luisi (Cambridge University, UK)
Marshall Stark (University of Glasgow, UK)
Richard Bowater (University of East Anglia, UK)
12:30 - 14:00 Registration with lunch
V(D)J recombination: from regulation to 3D assembly
Wei Yang (National Institutes of Health, USA)
How do helicases know which way to walk?
Dale Wigley (Cancer Research, UK)
Assembly of a machine for concurrent action at eight phosphodiester bonds
Selected oral communication - Jacqui Marshall (University of Bristol, UK)
15:20 - 15:50 Coffee/tea break
Chromatin structure and regulation of its compaction
Daniela Rhodes (University of Cambridge, UK)
Single-molecule techniques for monitoring topology, transcription, and replication
Nynke Dekker (Delft University of Technology, The Netherlands)
Mass Spectrometry reveals the subunit architecture of eukaryotic RNA polymerases I and III
Selected oral communication - Laura Lane (University of Cambridge, UK)
17:10 - 18:30 Drinks reception with poster session one (odd numbers)
Induced fit: a common strategy used by the ribosome in decoding , peptidyl transferase and termination
Venki Ramakrishnan (MRC Laboratory of Molecular Biology, UK)
Orchestrating serine resolvases
Phoebe Rice (The University of Chicago, USA)
Site-specific recombination by ƒÖC31 integrase
Maggie Smith (University of Aberdeen, UK)
A single-strand cleavage reaction provides insight into the catalytic mechanism of Tn3 resolvase
Selected oral communication - Femi Olorunniji (University of Glasgow, UK)
Identification of an ancient RNA machine for protein biosynthesis within the contemporary ribosome
Selected oral communication - Ada Yonath (Weizmann Institute, Israel)
10:40 - 11:10 Coffee/tea break
The anatomy and action of molecular machines that replicate and segregate DNA
David Sherratt (University of Oxford, UK)
High-throughput structure/function analysis of the nucleotide addition cycle of RNA polymerase
Selected oral communication - Robert Weinzierl (Imperial College, London, UK)
Substrate recognition and catalysis by flap endonucleases
Selected oral communication - Jane Grasby (University of Sheffield, UK)
12:20 - 14:00 Lunch with poster session two (even numbers)
Lesion recognition in DNA replication and repair
Lorena Beese (Duke University, USA)
DNA topoisomerases: coupling ATP hydrolysis to DNA strand passage
Tony Maxwell (John Innes Centre, Norwich, UK)
A re-appraisal of the role of ATP in type II topoisomerases
Selected oral communication - Andy Bates (University of Liverpool, UK)
15:20 - 15:40 Coffee/tea break
Polymerase-mediated orchestration of DNA double-strand break repair processes
Aidan Doherty (University of Sussex, UK)
19:00 - 20:30 Conference Dinner
Tales of transposons: machines that move DNA
Nancy Craig (Johns Hopkins School of Medicine, USA)
Recognition of branched DNA structure by junction-resolving enzymes
David Lilley (University of Dundee, UK)
10:30 - 11:00 Coffee/tea break
Using linked multimers to understand the action of the FtsK DNA translocase
Selected oral communication - Estelle Crozat (University of Oxford, UK)
Crystal structures of human RECQ1 protein in complexes with DNA and ADP
Selected oral communication - Opher Gileadi (University of Oxford, UK)
Ticket to slide: energy-efficient motion on DNA by a helicase
Mark Szczelkun (University of Bristol, UK)
12:10 - 12:30 Meeting close - packed lunch on departure