Organizers:
Richard Bowater (University of East Anglia, UK)
Rhona Borts (University of Leicester, UK)
Malcolm White (University of St Andrews, UK)
Timetable
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The GlaxoSmithKline Award Lecture
Chair:
Richard Bowater (University of East Anglia, UK)
12:00 - 14:00 Registration
The GlaxoSmithKline Award Lecture
The DNA-damage response: new molecular insights and new approaches to cancer therapy
Stephen Jackson (University of Cambridge, UK)
The DNA-damage response: new molecular insights and new approaches to cancer therapy
Stephen Jackson (University of Cambridge, UK)
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Session 1
Chair:
Richard Bowater (University of East Anglia, UK)
The association of sequence variants in DNA repair and cell cycle genes with cancer risk: genotype/phenotype correlations
Janet Hall (INSERM, Orsay, France)
Translational re-programming following UVB irradiation is mediated by DNA-PKCS and allows selective synthesis of MRNAs Encoding DNA repair enzymes
Selected oral communication - Alexander Kondrashov (University of Nottingham, UK)
15:45 - 16:15 Coffee/tea break
TREX1 exonuclease of mammalian cells, association with DNA replication and inherited inflammatory disease
Tomas Lindahl (CR-UK, London Research Institute, UK)
Oxidative DNA damage and DNA repair in sporadic Amyotrophic Lateral Sclerosis
Selected oral communication - Fabio Coppedè (University of Pisa, Italy)
Lorena Beese (Duke University, USA)
17:30 - 19:30 Poster session 1 (odd numbered posters)
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The Colworth Medal Lecture
Chair:
Stephen Jackson (University of Cambridge, UK)
The Colworth Medal Lecture
John Rouse (University of Dundee, UK)
Roles of protein kinases in maintenance of genome stability and DNA repair
John Rouse (University of Dundee, UK)
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Session 2
Chair:
Kevin Hiom (MRC - LMB, Cambridge, UK)
Precise repair of IES excision sites in Paramecium is mediated by the Non Homologous End-Joining pathway (NHEJ)
Selected oral communication - Aurélie Kapusta (Gif-sur-Yvette, France)
Polymerase-mediated orchestration of DNA double-strand break repair processes
Aidan Doherty (University of Sussex, UK)
10:45 - 11:15 Coffee/tea break
Exploiting our shared ancestry with the Achaea: structure and mutation of the DNA repair helicase XPD
Malcolm White (University of St Andrews, UK)
Altered function p53 missense mutations associated with breast cancers
Selected oral communication - Jennifer Jordan (University of North Carolina , USA)
Genomic instability and cancer: lessons from analysis of Bloom's syndrome
Ian Hickson (CR-UK, Oxford Cancer Centre, UK)
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The Sir Frederick Gowland Hopkins Memorial Lecture
Chair:
Malcolm White (University of St Andrews, UK)
The Sir Frederick Gowland Hopkins Memorial Lecture
Coping with stress: the multiple talents of p53
Karen Vousden (Beatson Institute for Cancer Research, UK)
Functions of p53 in metabolism and invas
Karen Vousden (Beatson Institute for Cancer Research, UK)
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Session 3
Chair:
Malcolm White (University of St Andrews, UK)
DNA double strand breaks, translocations and lymphoma
Fred Alt (Harvard University, USA)
Nesprin-2 associates with PML NBs to mediate DNA damage repair and safeguard genomic integrity
Selected oral communication - Derek Warren (Kings College London, UK)
16:15 - 16:45 Coffee/tea break
How heterochromatin influences DNA double strand break repair in mammalian cells
Penny Jeggo (University of Sussex, UK)
Dephosphorylation of Tyrosine-Phosphorylated H2AX regulates apoptosis and cell survival decision
Selected oral communication - Peter Cook (University of California, San Diego, USA)
Single-strand break repair and neurodegenerative disease
Keith Caldecott (University of Sussex, UK)
18:00 - 19:00 Drinks reception
19:00 - 22:00 Conference Dinner
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Session 4
Chairs:
Ian Hickson (CR-UK, Oxford Cancer Centre, UK)
Nicola Royle (University of Leicester, UK)
Wednesday 17 December 2008
Targeting telomeric DNA as a therapeutic strategy
Stephen Neidle (University of London, UK)
The role of recombination in telomere length maintenance
Nicola Royle (University of Leicester, UK)
The gene mutated in the riddle syndrome regulates a ubiquitin-dependent signalling cascade at sites of DNA damage
Selected oral communication - Grant Stewart (University of Birmingham, UK)
The role of BRCA1 in the repair of DNA damage
Kevin Hiom (MRC - LMB, Cambridge, UK)
10:45 - 11:15 Coffee/tea break
The role of DNA damage in cancer, ageing and longevity
Jan Hoeijmakers (Erasmus Medical Center, the Netherlands)
Single molecule studies on the DNA damage removal complex UvrBC of the nucleotide excision repair machinery
Selected oral communication - Ingrid Tessmer (University of Würzburg, Germany)
Replication-associated homologous recombination as a target in cancer therapy
Thomas Helleday (University of Oxford, UK)
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Session 5
Chair:
Rhona Borts (University of Leicester, UK)
Wednesday 17 December 2008
Chromosomal instability in the pathogenesis and treatment of cancer
Ashok Venkitaraman (University of Cambridge, UK)
Hierarchy of non-homologous end-joining, single-strand-annealing and gene conversion at site-directed DNA double-strand breaks
Selected oral communication - Wael Yassin Mansour (University Medical Center Hamburg-Eppendorf, Germany)
Recombination at DNA replication fork barriers is not universal
Selected oral communication - Ramsay McFarlane (Bangor University, UK)
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The Novartis Medal and Prize Lecture
Chair:
Rhona Borts (University of Leicester, UK)
Wednesday 17 December 2008
The Novartis Medal and Prize Lecture
Defective DNA strand break repair and relationships to human disease
Stephen West (CR-UK, London Research Institute, UK)
Defective DNA strand break repair and relationships to human disease
Stephen West (CR-UK, London Research Institute, UK)
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