Biochemical Society Focused Meeting
This meeting will be taking place as a satellite to BioScience2004. If you'd like to attend this satellite meeting you will need to register.
Proceedings will be published in Biochemical Society Transactions
G protein-coupled receptors (GPCRs) represent the largest single family of therapeutic targets within the pharmaceutical industry. Drug development strategies for GPCRs have traditionally focused on identifying ligands targeted against individual GPCRs. This strategy is based on the premise of a classical orthosteric ligandGPCR interaction. However, additional allosteric mechanisms, which modulate GPCR signalling independently of the traditional ligand binding domain, are becoming progressively more important within the drug discovery environment. Such allosteric co-factors, by regulating the function and pharmacology of ligand-GPCR interactions, provide new insights and challenges to the understanding of GPCR function. This one-day satellite symposium will address the complex role of allosteric modulation through co-factors acting at alternative binding sites on GPCRs and explore pharmacological modulation resulting from GPCR dimerization or accessory protein interaction. Allosteric modulation of GPCRs represents an increasingly important concept in GPCR research with far-reaching consequences for future therapeutic strategies. The meeting aims to complement the BioScience2004 mini-symposium 'Regulators of GPCR Specificity and GPCR Dimerization' and represents a timely opportunity to bring together key scientists to discuss this important area of GPCR research
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