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Molecular Structure in Ligand-Gated Ion Channel Function

29 January 2004

Merck Sharp & Dohme, Harlow, UK




Relevant Publications

Kash, T.L., Jenkins, A., Kelley, J.C., Trudell, J.R. and Harrison, N.L. (2003 Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature (London) 421, 272-275

Miyazawa, A., Fujiyoshi, Y. and Unwin, N. (2003) Structure and gating mechanism of the acetylcholine receptor pore. Nature (2003) 424, 949-955

Kelley ,S.P., Dunlop, J.I., Kirkness, E.F., Lambert, J.J. and Peters, J.A. (2003) A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. Nature (London) 424, 321-324

Hosie, A.M., Dunne, E.L., Harvey, R.J. and Smart, T.G. (2003) Zinc-mediated inhibition of GABA(A) receptors: discrete binding sites underlie subtype specificity. Nat. Neurosci. 6, 362-369

Newell, J.G. and Czajkowski, C. (2003) The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating. J. Biol. Chem. 278, 13166-13172

Reeves, D.C., Goren, E.N., Akabas, M.H. and Lummis, S.C. (2001) Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis. J. Biol. Chem. 276 42035-42042

Reynolds, D.S., Rosahl, T.W., Cirone, J., O'Meara, G.F., Haythornthwaite, A., Newman, R.J., Myers, J., Sur, C., Owain, H., Rutter, A.R. et al. (2003). Sedation and anaesthesia mediated by distinct GABAA receptor isoforms. J. Neurosci., in press


Registration Fees

Fees

Full Member 50
Student Member 25
Non Member 75
Late Fee (charged after 19 December 2003) 50

All payments must be made prior to the Conference.

The following methods will be accepted:

Credit card/Debit card
(Preferred method of payment, and the only acceptable form of payment for online registration)

The following credit/debit cards will be accepted:

American Express, Eurocard, Mastercard, Switch, Visa

Cheques
Please include payment with your registration form. Types of cheques accepted (made payable to Portland Customer Services) are:

Sterling cheques, drawn on a UK bank.

US dollar cheques, drawn on a US or London bank.

Euro cheques (in Euro currency NOT Eurocheques).

Bank drafts are accepted as follows:
Drafts must be in pounds sterling, drawn on a UK bank or US dollars drawn on a US or London bank. Must be made payable to Portland Customer Services.

Bank transfer

Registration fees can be accepted by bank transfer. Please make sure you include the reference 'Ligand-Gated reg. fees' and your family name.

Bank:
NatWest, 25 High Steet, Colchester CO1 1DG

Sort Code: 60-06-06

Account: Portland Press Limited

Account Number: 01863630

SWIFT code: NWBKGB2112B


Trade Exhibitors

There will be an all day trade exhibition in the Main Coffee Lounge.

Exhibitors will be:

Molecular Devices

Scientifica Ltd

MicroCal LLC

Amaxa GmbH

Delegate bags will also include information from Sigma-Aldrich


Venue

This Biochemical Society Focused Meeting is taking place at Merck Sharp & Dohme, Harlow, UK

The Neuroscience Research Centre
Merck Sharp & Dohme
Terlings Park
Eastwick Road
Harlow
Essex CM20 2QR, UK



Registration

Registration for the Meeting is now closed.


All payments must be made prior to the Conference.

Paying by Credit Card or cheque
Please include payment with your registration form.

Only fully paid delegates will be admitted to the Conference.

Please note that registration for this meeting will close on Wednesday 21 January 2004. Late registrants cannot be admitted for security reasons.


Accommodation

Delegates should arrange their own accommodation.

Please enquire at the hotels listed below stating that you are attending a Conference at Merck Sharp & Dohme, Harlow:

Manor of Groves Hotel
~ 3 miles (5 - 10 minutes by car) from Merck Sharp & Dohme, Terlings Park
Telephone: +44 (0) 1279 600 777
Fax: +44 (0) 1279 600 374
www.manorofgroves.com
Single room B&B 68.00 per night

Swallow Churchgate Hotel
~ 4 miles (10 minutes by car) from Merck Sharp & Dohme, Terlings Park
Telephone: +44 (0) 1279 420 246
Fax: +44 (0) 1279 437 720
www.swallowhotels.com
Single room B&B 82.00 per night
Double room (single occupancy) B&B 87 per night

Down Hall Country House Hotel
~ 7 miles (15 minutes by car) from Merck Sharp & Dohme, Terlings Park
Telephone: +44 (0) 1279 732 144
Fax: +44 (0) 1279 730 921
www.downhall.co.uk
Single room (room only) 88.00 per night
Full english breakfast 15.95 per person
Continental breakfast 10.50 per person





Poster abstract submission

Submission of poster abstracts is online only. The deadline for poster abstract submission has now passed.

All poster abstracts will be available to view online two weeks prior to the meeting.

Poster boards are 1.2 m high x 1m wide.

Velcro will be provided on all poster boards and at the Biochemical Society registration desk.

Any attendees wishing to submit a poster after the abstract deadline should contact the Meetings Office on +44 (0) 20 7580 3481 or email meetings@biochemistry.org for more information.

Late posters will not have their accompanying abstracts published in the Meeting's Programme Book.


Travelling to Merck Sharp & Dohme, Harlow

By Air
London Stansted - Delegates are advised to take a taxi directly to Merck Sharp & Dohme, Harlow.

Heathrow - Delegates are advised to take the Heathrow Express into London Paddington and London Underground to London Liverpool Street where trains depart to Harlow Town station.

Gatwick - Delegates are advised to take the Gatwick Express into Victoria then the London Underground to London Liverpool Street where trains depart to Harlow Town station.

London Luton Airport - Delegates are advised to take the train to King's Cross and then the London Underground to London Liverpool Street where trains depart to Harlow Town station

London City - Delegates are advised to take the green shuttle bus to Canning Town Station and then London Underground to London Liverpool Street where trains depart to Harlow Town station.

By Train
Trains run direct from London Liverpool Street (the Bishops Stortford or Cambridge line) to Harlow Town station.

Merck Sharp & Dohme have kindly arranged for a courtesy mini bus to transport Delegates between:
Harlow Town Station, The Moorhen Public House (car park) and Terlings Park
between the hours of:
09:00 - 10:30 and 17:30 - 18:30.

Taxis are available at the station for the short journey to Merck Sharp & Dohme.

For further information regarding train times and tickets please contact National Rail Enquiries
(telephone: +44 (0) 8457 48 49 50) or visit thetrainline

By Coach
National Express run coach services to London Stansted airport, where attendees are then advised to catch a taxi to Merck Sharp & Dohme.
For further information regarding coaches visit National Express Coach Service or call + 44 (0) 8705 80 80 80

By Car
On-site parking is not available at Merck Sharp & Dohme.

Delegates wishing to drive to the conference should please inform meetings@biochemistry.org, providing your registration details.

A car park for Delegates has been arranged at The Moorhen Public House, Burntmill Lane, a short distance from Terlings Park.

A courtesy mini bus will transport Delegates to and from the conference between the hours of:
09:00 - 10:30 and 17:30 - 18:30.


Map Reference
Detailed Map
Map A
or Area Map (NB: Research Park in central grid)
Map B

Please see the AA or RAC for route advice.


Confirmation letter

All registered delegates will be sent a confirmation e-mail to confirm registration details. This letter should be checked carefully to ensure that all requirements are correct. In particular, the spelling of names and affiliations should be checked, as this information will be used to create badges.
Confirmation e-mails also act as a receipt, and should also contain venue maps and delegate information. Please bring the letter with you to the conference.

If you have not received a confirmation e-mail two weeks before the meeting, please contact Portland Customer Services on +44 (0) 1206 796 351


Refunds

Cancellations will be accepted in writing until Wednesday 14 January (subject to a 15 cancellation fee). After this date, neither full nor partial refunds can be given.


Disabled access

Disabled access is available. It would be helpful if you could let Hannah Baker(hannah.baker@biochemistry.org) know in advance if you require any special assistance during your visit to Harlow.


Official letter of invitation

Official letters of invitation, which are intended to assist with administrative arrangements in certain countries, will be issued upon request once an abstract has been submitted (and accepted), and registration fees have been received. Such letters do not imply commitment of financial or other support by the organizers.