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2 July 2003 Poster Session 1: 12:20 - 14:00
A1 Iron chelators reduce ferryl myoglobin and inhibit cytotoxic haem-to-protein cross-linking
BJ Reeder, R Hider, MT Wilson
A10 Activation of cytochrome c to a peroxidase compound I-type intermediate by H2O2: Relevance to redox signalling in apoptosis
M Burkitt, C Jones, A Lawrence, P Wardman
A2 Analysis of the kinetic properties of the cytidylyl cyclase
Reza Hajihosseini
A3 Characterisation of the peroxynitrite generating capacity of xanthine oxidase
TM Millar
A4 Rates of intrinsic ligand binding in Met80 mutants of ferrocytochrome c as a probe for flexibility of the distal haem pocket
G. Silkstone, M.T Wilson
A43 INHIBITION OF INORGANIC PYROPHOSPHATASE AS AN ALTERNATIVE NO-INDEPENDENT MECHANISM OF AMINONAPHTHALENESULFONAMIDE (ANSA) TOXICITY
O.A. Pavlova, N.V. Beda, A.A. Nedospasov
A44 Free radical oxalate-degrading enzymes
S Bornemann, L Bowater, M R Escutia, D M Lawson, C E M Stevenson, A Tanner, V Winter
A5 Biphasicity in the reaction of human haemoglobin A with Hydrogen peroxide; A stopped-flow study
M.M Wankasi, M.T. Wilson
A6 NADH oxidation and Superoxide production by goats' milk xanthine oxidoreductase
D ATMANI, M BENBOUBETRA
A7 Eccentric Exercise Induces Oxidative Modification of Haemoglobin
R.J Levermore, A.J Irwin, C.E Cooper
A8 Prostaglandin H-synthase-2 catalytically consumes nitric oxide in monocytic cells.
SR Clark, C Keigwin, MJ Coffey, AR Roberts, LJ Marnett, VB O'Donnell
A9 The cellular effects of myeloperoxidase-derived chlorinated products
CM Spickett, G Dever, C Paredes Oliveira, LJ Stewart
C7 A sequence approach to predicting protein interfaces
MJ Frusher, MK Dean, RE Smith, CA Reynolds
C8 On the role of transmembrane helix 4 in G-protein coupled receptors
HSX Clark, NJ Kidley, RE Smith, GJG Upton, CA Reynolds
C9 Assessing models of the b2-adrenergic receptor as targets for virtual screening
G Psaroudakis, H Brooks, N Kidley, C Reynolds
D1 The Role of Uncoupling Protein-2 in Pancreatic Beta-cells
K Green, M P Murphy, M D Brand
D2 Reduction of one-electron acceptors by cellobiose oxidoreductase.
M.G. Mason, M.T. Wilson, P. Nicholls
D3 Ubiquinone is not required for UCP1 function in mitochondria
T C Esteves, K S Echtay, M D Brand
D4 KINETICS OF SUPEROXIDE SCAVENGING BY GLUTATHIONE: AN EVALUATION OF ITS ROLE IN THE REMOVAL OF MITOCHONDRIAL SUPEROXIDE
C M Jones, A Lawrence, P Wardman, M J Burkitt
D5 NOVEL SOD AND CATALASE MIMICS FOR THE TREATMENT OF INFLAMMATORY DISEASES
A.E.O. Fisher, S.C. Maxwell & D.P. Naughton.
D6 Control of superoxide production in cauliflower mitochondria
V. Popov, A.M. Wagner, K. Krab
D7 Requirement for 12/15-LOX in angiotensin II-induced hypertension in vivo
PB Anning, MJ Coffey, SR Clark, B Coles, H Kuhn, VB O'Donnell
D8 Mitochondrial DNA versus Nuclear DNA: A Comparative Analysis of Oxidative Stress-Induced Genomic Injury and Repair in Various Cell-Types
S.G Jarrett, M.E Boulton
E1 IDENTIFICATION OF ADIPOCYTE GLYCERONEOGENESIS AS A MAJOR TARGET FOR THE HYPOLIPIDEMIC ACTION OF THIAZOLIDINEDIONES
B. Antoine, J. Tordjman, G. Chauvet, J. Quette, E.G. Beale, C. Forest
E2 SCHAD deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle?
S Eaton, I Chatziandreou, S Krywawych, S Pen, PT Clayton, K Hussain
E3 Mechanism of glucose sensing in the small intestine.
J Dyer, S Vayro, SP Shirazi-Beechey
E4 Post-transcriptional regulation of the intestinal Na+/glucose co-transporter (SGLT1) in response to lumenal glucose.
J Dyer, AW Moran, I Stern, SP Shirazi-Beechey
E5 AZD7545 is a Selective Inhibitor of Pyruvate Dehydrogenase Kinase2.
J.A. Morrell, R.J. Butlin, U. Chauhan, R.M Mayers, J.P. Orme, D. Roberts, T.E Roche, L. Sanchez, C. Summers, E. Kilgour
E6 AZD7545, a novel inhibitor of PDHK2, activates PDH in vivo and improves blood glucose control in obese (fa/fa) Zucker rats
R M Mayers, R J Butlin, E Kilgour, D A Martin, J Myatt, J P Orme, B R Holloway
E7 The in vitro characterisation of a novel Glucokinase activator
D Carroll, HJ Wightman, HL Vertigan, C Johnstone, B Leighton, MP Coghlan, KJ Brocklehurst
E8 A physiology-based model of NEFA homeostasis
K. Jelic, M. Colding-Jørgensen
G1 Physiological function of RAGE?
A. Bierhaus, B. Arnold, P. Nawroth
G2 Peptide mapping of human serum albumin modified minimally by methylglyoxal
N Ahmed, Y Hou, PJ Thornalley
G3 Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiency
N Ahmed, S Battah, N Karachalias, R Babaei-Jadidi, M Horányi, K Baróti, S Hollan, PJ Thornalley
G4 Argpyrimidine modified Hsp27 is predominantly present in human lung squamous cell carcinomas as opposed to adenocarcinomas
JWJ van Heijst., HWM Niessen, K Hoekman, RJ Musters, K Uchida, CG Schalkwijk
G5 Tissue protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids
M Portero-Otin, MJ Bellmunt, JR Requena, R Pamplona
G6 DIMETHYL SULFOXIDE PROTECTS ENDOTHELIAL CELLS AGAINST ADVANCED GLYCATION ENDPRODUCT¿MEDIATED TOXICITY
M.S Ahmad, Y. Duraisamy, M. Slevin, J. Gaffney, C.A. Smith, N. ahmed
G7 Borderline Thiamin Deficiency Induces Aberrant Crypt Foci (ACF) in the Colons of Rats on a Sucrose-based diet
WRB Bruce, RF Furrer, NS Shangari, PJO O'Brien, AM Medline, YW Wang
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3 July 2003 Poster Session 2: 17:30 - 19:00
A11 The erythrocyte cytoskeleton and Ca2+-induced hyper-polarization in diabetes and alcoholism
V.D. Prokopieva, I.V. Petrova, A.V. Sitozhevskii, S.V. Kremeno, O.V. Tyulina, P. Johnson
A12 Protein modification in human erythrocytes in the presence of ethanol and acetaldehyde
O.V. Tyulina, V.D. Prokopieva, E.V. Denisova, P. Johnson
A13 Nitric oxide level and antioxidant defense in patients with gastric cancer
Y Dincer, T Akcay, O.B. Tortum, Z Alademir, G Doðusoy
A14 Probing the role of mitochondria in tumour necrosis factor signalling using mitochondrially-targeted reagents
E.C.Ledgerwood, G.Hughes, M.P.Murphy
A15 Targeted effects of irradiation on an in vitro blood-brain barrier model
VC Stewart, RD Hurst, M Folkard, BD Michael, KM Prise
A16 Splice variants of glutathione synthetase in Drosophila melanogaster
E.J. Shanks, M.Y. Gwarzo, R.D.C. Saunders, L.I. McLellan
A17 EFFECT OF THE MOLECULAR CHAPERONE GroESL ON IRON AND MANGANESE SUPEROXIDE DISMUTASE FROM ESCHERICHIA COLI.
T Hunter, GJ Hunter
A18 The effect of HDL on lipid levels in THP-1 macrophages exposed to chylomicron remnants
EH Moore, MA Avella, KE Suckling, KM Botham
A19 The effect of hemin on the mitochondrial respiratory chain
AJ Heslegrave, VC Stewart, MA Sharpe, JB Clark
A20 Mitochondrial Thiol Redox Changes During Apoptosis
NJ Costa, MP Murphy
A21 Reactive Oxygen Species Production and Mitochondrial Thiol Redox Changes during Apoptosis
CC Dahm, MP Murphy
A22 Effect of addition of L-ascorbic acid megadoses to the diet on the antoxidative/oxidative state in the rats
T Niemiec, E Sawosz
A23 In vivo distribution and mobility of a truncated PARP-1 fusion protein in rat fibroblast cells
N Syrett, I.E.G. Morrison, R.J. Cherry, M.K. O'Farrell
A24 The origin of the nitration and chlorination of proteins in atherosclerotic plaques
T Harrison, S.Y. Low, D Baker, K.R. Bruckdorfer
A25 Revisiting the TBARS Assay: Protein Bound Plasma Levels of Malondialdehyde are Overestimated
NBJ Vollaard, JP Shearman, CE Cooper
A26 Activity of NAD(P)H oxidases in vascular fibroblasts of normotensive and hypertensive rat
M Vejra¿ka, M Orlický, S ¿típek
A27 Characterisation and regulation of the human sodium-dependent vitamin C transporter isoforms (hSVCT1 and hSVCT2) in mammalian cells by hypoxia.
S.P. Rosier, W.-J. Liang, S.M. Jarvis
A28 Role of S-nitrosohemoglobin in vascular dysfunction associated with Sepsis
JH Crawford, RP Patel
A29 Nitric oxide and reactive oxygen species interactions in cell death
gc brown, a price, p mander, v borutaite
A30 Proteomics Analysis of Cellular Responses in Drosophila melanogaster to Oxidative Stress.
J Mathers, R.A. Akhtar, J. Bone, R.D.C. Saunders, L.I. McLellan
A40 Rhenium cluster compounds can effectively modulate POL intensity in erythrocytes
I.I. Patalakh, N.I. Shtemenko
A41 Oxidative stress and redox homeostasis of RBC in blood of children with perinatal lesion of CNS
I.I. Patalakh, I.S. Yukhimenko
A42 Free radicals in cardiopulmonary bypass (CPB)?: Is there a role in the systemic inflammatory reaction.
MM Elahi, B Ajay, BM Matata, M Galinanes
B1 TOWARDS AN UNDERSTANDING OF THE ROLE OF THE SIGMA-1 RECEPTOR IN CANCER.
E.S. Poon, S. Hobbs, W. Courts, S.A. Eccles
B2 Reconstituting amyloid precursor protein (APP) processing \italicise{in vitro} and \italicise{in vivo}
C. Duggan, S. High
B3 The Biosynthesis of a Polytopic Membrane Protein at the Endoplasmic Reticulum
N. Ismail, S. High
B4 Notch protein as a model substrate for intramembrane proteolysis.
JE Barks, S High
B5 Interactions of Hsp70 ER Lumenal Chaperones
DM Fullerton, CJ Stirling
C1 Protease activated receptors on airway epithelial cells influence tight junction recovery following disruption
JR Purkiss, AF Walls
C2 Stress-Induced ATP Release and Growth Modulation of Human Lens and Retinal Pigment Epithelial Cells
JA Eldred, J Sanderson, IM Wormstone, JR Reddan, G Duncan
C3 Signalling pathway involved in LPA-dependent cell migration
T MAFFUCCI, M FALASCA
C4 Bivalent b2-adrenergic ligands
GA Jones, N Nikbin, NJ Kidley, C Edwards, CA Reynolds
C5 Active and inactive conformations of the b2-adrenergic receptor
MK Dean, NJ Kidley, PR Gouldson, RP Bywater, C Diaz, D Shire, CA Reynolds
D10 Cytochrome oxidase dysfunction: alteration of enzyme assembly and inhibition by NO
S Horan, B Meunier
D11 Yeast as a Model for Investigating Mitochondrial Oxidative Damage
HM Cochemé, MP Murphy
D12 Inhibition of UCP3 causes mitochondrial oxidative damage
D.A. Talbot, K.S. Echtay, M.D. Brand
D13 Mitochondrial matrix ROS production is very sensitive to mild uncoupling
S Miwa, M.D. Brand
D14 Roles of peroxide and superoxide in the aerobic redox cycles of Sclerotium rolfsii cellobiose dehydrogenase.
P. Nicholls, M. Zamocky, D. Haltrich
D15 Hypoxia simultaneously induces the expression of gp91phox and endothelial nitric oxide synthase which promotes peroxynitrite formation in the pulmonary artery
S Muzaffar, N Shukla, GD Angelini, JY Jeremy
D16 Effects of reduced oxidative tension on T cell biology as a function of in vitro age
O Duggan, K Annett, P Hyland, Y Barnett
D17 How exactly does ABA increase the plant resistance to drought?
B.A. Kurchii
D9 Antiapoptotic Bcl-2 protein may protect CV1-P cells from 6-OHDA-induced toxicity
SM Manakova, KP Puttonen, PTM Mannisto
G10 Effect of non enzymatic glycation on aluminium induced lipid peroxidation of human HDL
G Ferretti, T Bacchetti, C Marchionni, N Dousset
G11 Low GDP fluid has beneficial effects in peritoneal dialysis patients
P Rutherford, A Williams, A Wieslander
G12 Relationship between genetic polymorphism of antioxidant enzyme and diabetic complications
K Kankova, I Marova, A Stejskalova
G13 Accumulation of fructosyl-lysine and advanced glycation endproducts in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats
N Karachalias, R Babaei-Jadidi, N Ahmed, PJ Thornalley
G14 High concentrations of advanced glycation endproducts in cellular protein.
AJ Lucas, N Karachalias, N Ahmed, PJ Thornalley
G8 Identification of Heat-shock protein 27 (Hsp27) as a major methylglyoxal-modified protein in endothelial cells
C. Schalkwijk, M. Bourajjaj, J. van Bezu, R. Schors, C. Sehouwer, K. Uchida, V. van Hinsbergh
G9 The role of glyoxalase-1 inhibition on endothelial cell activation.
M Bourajjaj, J van Bezu, C.D.A. Stehouwer, V van Hinsbergh, C.G. Schalkwijk
I1 Comparison of effect of De-Odorase on dry matter degradation of straw, hay and concentrates in ovine ruminal fluid in vivo
JP Ryan, J Mullally, T Quinn, BF Leek
I2 Helix Packing in Membrane Proteins
MP Campbell, CA Reynolds
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4 July 2003 Poster Session 3: 12:50 - 14:15
A31 Nitric oxide in the mouse preimplantation embryo
RC Manser, HJ Leese, FD Houghton
A32 Glutamate loading protects isolated cardiomyocytes against oxidative stress by stimulating glutathione peroxidase
N King, A.P. Halestrap, J.D. McGivan, M.-S. Suleiman
A33 Lipoxygenase activity during developmental growth of green banana tissue (Musa sp.)
L. E. Williams, M. Williams
A34 The control of mitochondrial respiration by nitric oxide is altered by chronic ethanol consumption
S Shiva, A Venkatraman, SM Bailey, VM Darley-Usmar
A35 Regulation and targets of protein S-thiolation in the yeast Saccharomyces cerevisiae
D Shenton, CM Grant
A36 Nitric oxide, peroxynitrite and antioxidants as regulators of collagen biosynthesis in skin fibroblasts
E Truelove, A Dooley, S Low, D Abraham, R Bruckdorfer
A37 Auto-regulation of glutathione biosynthesis in Saccharomyces cerevisiae in response to glutathione concentration.
GL Wheeler, CM Grant
A38 The role of intermolecular disulphide linkages in regulating Drosophila melanogaster glutamate cysteine ligase activity
JA Fraser, RDC Saunders, LI McLellan
A39 Regulating 15-lipoxygenase oxidation of membrane-bound arachidonate by protein kinase C in human monocytes.
A Bermudez-Fajardo, B Coles, MJ Coffey, VB O'Donnell
B10 Effect of Oxidoreductases on Intracellular folding of Tissue-type Plasminogen Activator.
S Chakravarthi, NJ Bulleid
B11 The Role of ERO1 in Disulphide Bond Catalysis
R Watkins, CA Hoare, NJ Bulleid.
B12 Characterising the Endoplasmic Reticulum Oxidoreductins in Arabidopsis thaliana
D Dixon, M van Lith, R Edwards, A Benham
B13 Membrane Protein Integration at the ER: a Search for Novel Chaperones
FJL Lecomte, S High
B14 Tail-anchored protein integration at the ER membrane
BM Abell
B15 Collagen assembly in C. elegans: interactions between obligate partners
B Roberts, I.L. Johnstone
B6 Identification of a Dlhs1 Dire1 suppressor
L C S Smith, C J S Stirling
B7 Dissecting the roles of Sec63p in protein translocation
A. J Jermy
B8 The Transient Association of Ribophorin I with Amyloid Precursor Protein
CM Wilson, C Kraft, S High
B9 Topology of human Na+dependent vitamin C transporters
A.M. Velho, M.J. Carden, S.M. Jarvis
F1 Dietary modulation of inflammation: interactions between isoflavones and physical forces
AN Mundhekar, R Chandler, H Pruitt, B Chacko, D Kucik, RP Patel
F2 Exercise Tolerance in Glycogenosis Type I (GSD-I)
HR Mundy, P Georgiadou, R Wensel, AJ Cousins, PJ Lee
F3 Regulation of pyruvate dehydrogenase flux and activity in primary cultures of rat myotubes
N Grunnet, L Frandsen, B Quistorff
F4 The effect of exercise on glucose and fatty acid metabolism in sedentary male subjects
F Shojaee-Moradie, K Baynes, C Pentecost, J Bell, L Thomas, NC Jackson, M Stolinski, RH Jones, AM Umpleby
F5 AMP-stimulated uncoupling of mitochondria from Drosophila melanogaster mutants expressing different amounts of the Adenine Nucleotide Translocase
E J Cornwall, M D Brand
G15 Removal of advanced glycation end products in clinical renal failure by peritoneal dialysis and haemodialysis
S Agalou, N Ahmed, PJ Thornalley
G16 Short-Term High Glucose Exposure Induces Pentosidine Formation in Retinal Microvascular Endothelial Cells
N Frizzell, S J Hughes, S R Thorpe, A W Stitt
G17 Mechanism of Glyoxal cytotoxicity under conditions of high glucose-induced oxidative stress
NS Shangari, PJO O'Brien
G18 Proteomic analysis of N-omega-(carboxymethyl)arginine formation in ribonuclease-glyoxal model systems
WE Cotham, DJS Hinton, TO Metz, JWC Brock, SR Thorpe, JW Baynes, JM Ames
G19 Hesperetin inhibits pentosidine formation in collagen incubated with glucose in vitro. In vivo, as long-term treatment, it lowers urinary albumin clearance in diabetic rats.
P URIOS, I KASSAB, A-M BORSOS, C GIRARD, J PEYROUX, M STERNBERG
G20 Modulation of AGE-induced genomic damage in kidney tubule cells
N. Schupp, H. Stopper, M. Scheurich, R. Schinzel, K. Sebekova, A. Heidland
G21 GA-pyridine, a major antigenic structure derived from glycolaldehyde-modified proteins, accumulates in human atherosclerotic lesions
R Nagai, Y Unno, X Ling, S Horiuchi
G22 Mechanistic Studies on the Induction of a Detoxyfying Enzyme, Glutathione-S Transferase, by Dietary Advanced Glycation End Products in Caco-2 Cells and in Rat Kidney Tissue
V Somoza, E Wenzel, H Zill, HF Erbersdobler, K Sebekova, A Heidland, M Lindenmeier, T Hofmann
G23 High levels of free advanced glycation endproducts in synovial fluid in arthritis
I Amajuoyi, N Ahmed, R Watts, PJ Thornalley
H1 Age-related vasomotor dysfunction may be due to altered Akt status in the endothelium
AR Smith, TM Hagen
H10 Effect of saturated N-acylethanolamine on corticosteroid level in irradiated animals
NM Gula, L Storozhuk, M Artamonov, O Zhukov, AA Chumak, OS Mikosha
H11 Stimulation of a Glycosylphosphatidylinositol-specific Phospholipase in Lipid Raft Domains Mediates Insulin-Mimetic Signaling in Rat Adipocytes by Triggering the Redistribution of Lipid Raft Components
Günter Müller, Anna Crecelius, Susanne Wied, Wendelin Frick
H12 Activation of platelet 12-lipoxygenase via the collagen receptor glycoprotein VI and inhibition by PECAM-1.
M Coffey, G Jarvis, J Gibbins, N Barrett, B Coles, O Wylie, V O'Donnell
H13 Increase in ROS production following UV irradiation accelerates aging via PKC signalling in a fibroblasts model
O Bussi, M Bergman, M Garbstein, Z Madar, S Grossman, T Tennenbaum
H14 COLOCALISATION OF CELL SURFACE RECEPTORS AT HIGH SPATIAL RESOLUTION BY SINGLE PARTICLE FLUORESCENCE IMAGING
I Karakikes, R E Barber, I E G Morrison, N Fernandez, R J Cherry
H15 Sprouty-attenuator in RTK signalling pathway
X Li, H Burns, J.K. Heath
H16 IBUPROFEN AND ALZHEIMER'S DISEASE: MEMBRANE-LINKED ENZYME ACTIVATION AND INHIBITION OF AMYLOIDOGENIC PEPTIDE FORMATION BY IBUPROFEN
J M BAILEY, J Y VANDERHOEK
H17 Paracrine and autocrine actions of sPLA2
A Jaulmes, V Antonio, B Janvier, M Raymondjean, M Andreani
H18 A functional polymorphic variant of DDAH2 in a basal promoter element
CT Tran, LC Jones, JM Leiper, P Vallance
H19 Rapid S-nitrosothiol metabolism by platelets and megakaryocytes
CM Shah, IC Locke, HS Chowdrey, MP Gordge
H2 Nuclear Vitamin D receptor/Tcf-4/Osteopontin signal transduction.
M McCann, M El-Tanani, M Hoper, G Posner, FC Campbell
H20 Co-ordinated regulation of the tumour suppressor gene p16 by beta-catenin-Lef-1 and Ets transcription factors.
C Murphy, M El-Tanani, M Hoper, FC Campbell
H21 Regulation of Map Kinase Phosphatase-2 (MKP-2) gene expression occurs via the Protein kinase C (PKC) and Extracellular-signal regulated kinase (ERK) dependent signalling cascades in hypertrophic cardiomyocytes
JS Kodituwakku, SJ Fuller
H3 Role of protein kinase C isoforms in LPS-induced cytokine secretion by human monocytic cells
C.A. Charalambos, S.A. Rushworth, M.A. O'Connell
H4 MnSOD Overexpression-induced Senescence is Independent of Nox1 Activity
L Behrend, G Henderson, R Zwacka
H5 The role of MAP kinases in lipoprotein-induced foam cell formation
LJ Parish, E Moore, M Avella, KM Botham, NT Goode
H6 Reactive Oxygen Species Mediate Intracellular Cholesterol Accumulation via Modulating Caveolin-1 pathway in Chinese Hamster Ovary Cells
Jiangang Shen, Cindy WS Lee, Peter CW Fung
H7 Vascular Cell Expression of the Vitamin C Transporters, SVCT1 and SVCT2
RM Ogborne, SA Rushworth, MA O'Connell
H8 The distribution of the exogenic N-palmitamide in the mammalian tissues
MV Artamonov, OD Zhukov, NM Gula
H9 Synergistic Interaction of Arachidonic Acid and 5-Hydroxytryptamine in Human Platelet Aggregation is Mediated Through Multiple Signalling Pathways
A.H. Gilani, H. Rasheed, S.A. Saeed
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