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PI 3-kinase in Signalling and Disease

11—12 November 2003

Novartis Horsham Research Centre, UK



11 November 2003

Poster Session 1: 17:15 - 19:00


P001 Recovery from lupus-like disease following PI3Kg deletion
D.F. Barber, C. Hernández, L.R. Borlado, C. Redondo, E. Hirsch, M.P. Wymann, D. Balomenos and A.C. Carrera
P002 Analysis of knock-in mice for a constitutively active lipid kinase form of PI3Kg
L. Barberis, C. Costa, O. Azzolino, A. Cuccurullo, S. Marengo, M.P. Wymann and E. Hirsch
P003 Identification of vimentin as a novel PI3Kg-dependent tyrosine-phosphorylated protein
L. Barberis, C. Pasquali, F. Vilbois, C. Costa, M.P. Wymann, C. Rommel and E. Hirsch
P004 Evidence for PI3K-independent directional T lymphocyte migration following CCR4 ligation
D. Cronshaw, C. Owen, Z. Brown and S.G. Ward
P005 Role of phosphatidylinositol-3-phosphate in cell signalling
T. Maffucci, F.T. Cooke and M. Falasca
P006 Using RNAi to determine the role of class II PI 3-kinases
F.M. Foster, C.J. Traer, S.M. Abraham and M.J. Fry
P007 PI-3-K Activation by Ischaemia/Reperfusion and Proinflammatory Stimuli in Cardiomyocytes and Its Role in Survival
R Heads, J Mockridge, N Smart, K Obasanjo, M Marber
P008 Upregulation of PI 3-kinase g by Bcr-Abl
F. Hickey and T.G. Cotter
P009 Analysis of P-REX1 a novel PtdIns(3,4,5)P3 and Gbg-regulated RAC exchange factor
K. Hill, S. Krugmann, H. Welch, P. Hawkins and, L. Stephens
P010 The CXCR3 ligands IP-10, ITAC and MIG stimulate PI3K-dependent signalling events in intestinal myofibroblasts
A. Kouroumalis, G. Kolios and S.G. Ward
P011 Over-expression of protein kinase B in human pituitary tumours
M. Musat, M. Korbonits, B. Kola, A. Nanzer, D.G. Morris and A.B. Grossman
P012 Activation kinetics and translocation of PKB in response to interleukin-3
N.A. Barnes, D. Xenaki and P.J. Owen-Lynch
P013 Characterisation of inter- or intra-molecular interactions in the regulatory subunit of PI3K
M. Pfuhl, J.D. Ladbury, P.C. Driscoll and P. Shepherd
P014 Competitive fluorescence polarization assays for the detection of phosphoinositide kinase and phosphatase activity
B.E. Drees, A. Weipert, H. Hudson, C.G. Ferguson, L. Chakravarty and G.D. Prestwich
P015 Dimerization in the transmembrane segments of tyrosine kinase-linked ErbB receptor proteins
AP Vegh, J-P Duneau, J Sturgis
P016 PI3K and Akt/PKB promote Cav channels translocation to the plasma membrane
P. Viard, A.J. Butcher, G. Halet, A. Davies, B. Nürnberg and A.C. Dolphin
P017 Vav proteins are required for ERK but not PI3-K activation following IgM crosslinking but are required for PI3-K activation in response to CD19 signalling
E. Vigorito, G. Bardi, J. Glassford, E.W.-F. Lam, E. Clayton and M. Turner
P018 The lipid phosphatase SHIP regulates SDF-mediated responses
C.M. Wain, J. Westwick and S.G. Ward
P019 An H2O2/ PI 3-kinase/FOXO feedback mechanism may function in starvation responses at the cost of longevity
D. Weinkove, F. Milano, J.R. Halstead, R.H. Plasterk and N. Divecha
P020 The involvement of phosphoinositide 3-kinases in regulating self-renewal of embryonic stem cells
H. Wheadon, N. Paling and M. Welham
P021 Function of the Gab-2-PI3K pathway in IL-3 signalling
B. Fox, C. Edmead and M. Welham
P022 The N-terminus of the class II phosphoinositide 3-kinase-C2b regulates lipid kinase activity and its binding to clathrin
M. Wheeler and J. Domin
P023 Novel G protein-independent activation of PI3Kg via Ca21 and PKC regulates allergy
S. Tornay, K. Björklöf, M. Laffargue, P. Küenzi, G.W. Reuther, E. Hirsch, P. Finan and M.P. Wymann
P024 Genetic evidence excludes loss of phosphoinositide 3-kinase g (PI3Kg) as direct cause of colon cancer
M. Barbier, T. Sasaki, S. Sancho, E. Ciraolo, A. Jarry, C. Curcio, E. Hirsch, J.M. Penninger and M.P. Wymann
P025 A fluorescent probe to visualize PKB/Akt activity in living cells
M. Böni and M.P. Wymann