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Cytokine/proteoglycan interactions: biology and structure

9—10 January 2006

Royal Holloway, University of London, UK



9 January 2006

Poster Session 1: 16:45-18:15


P001 Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs
A.J. Kungl, H. Wutschek, B. Brandner, V. Wabitsch and A.-M. Piccinini
P002 Design, synthesis and biological evaluation of small molecule heparin/heparan sulphate (H/HS) analogues as GAG–protein interactions inhibitors
E.-A. Raiber, J. Wilkinson, S. Ducki, M. Lyon and J.T. Gallagher
P003 Heparan sulphate influence the ripening of the human uterus
A. Holmberg, G. Ekman-Ordeberg and A. Malmström
P004 Spatially-restricted patterning cues provided by heparin-binding VEGF isoforms control blood vessel branching
C. Ruhrberg, H. Gerhardt, M. Golding, R. Watson, H. Fujisawa, C. Betsholtz and D.T. Shima
P005 Structural determination of heparan sulfate required for PDGF-BBL interaction in pericyte recruitment
S. Kurup, U. Lindahl, D. Spillmann, S. Yamada, A. Abramsson, P. Lindblom, C. Betsholtz and H. Gerhardt
P006 Characterisation of CXCL12/heparan sulphate complex and functional importance
R. Sadir, F. Baleux, A. Imberty and H. Lortat-Jacob
P007 A role for syndecan-1 in the cell responses induced by cyclophilin B
A. Melchior, R. Pakula, A. Denys, J. Mazurier and F. Allain
P008 Inhibition of breast cancer metastasis using short-length heparin oligosaccharides
P. Mellor, J. Harvey, S. Ali, J. Kirby, K. Murphy, and T. Lennard
P009 Basic FGF is bound to perlecan in the pericellular matrix of articular chondrocytes and acts as a mechanotransducer in loaded articular chondrocytes
T. Vincent, C. McLean and J. Saklatvala
P010 The binding of heparin to glial cell line-derived neurotropic factor (GDNF) and the closely related cytokines neurturin and artemin
I. Alfano, P. Vora, R. Mummery, B. Mulloy and C. Rider
P011 Calcium pentosan polysulphate increases levels of TIMP-3 in cartilage
L. Troeberg, C. Gendron, P. Ghosh and H. Nagase
P012 Characterisation of recombinant human interleukin 7 and its glycosaminoglycan binding properties
J. McRobb, R. Gibbs and D. Mernagh
P013 Demonstration of biological activity of heparin immobilised on microplates
E. Liefooghe, J. Whittle, E. Gray, J. Hogwood and C.J. Robinson
P014 Cellular responses to the HepII domain of fibronectin require N-sulphation of cell-surface heparan sulphate proteoglycan
Y. Mahalingam, J.T. Gallagher and J.R. Couchman
P015 Peptide inhibition of heparin-RANTES interactions
D. Vijayanand, J. Kirby, S. Ali, D. Rix and N. Carter
P016 The specificity of glycosaminoglycan interactions with hepatocyte growth factor/scatter factor (HGF/SF)
K.R. Catlow, J.A. Deakin, M.S.G. Pavão, M. Delehedde, D.G. Fernig, E. Gherardi, J.T. Gallagher and M. Lyon
P017 Disease-associated sequence variations congregate in a GAG recognition patch on human factor H revealed in 3D structure
A. Herbert, D. Uhrin, M. Lyon, M. Pangburn and P. Barlow