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Gene expression and analysis - Linked Focused Meetings

26—28 March 2008

University of Manchester, UK



27 March 2008

Poster Session 1: 09:00 - 10:30 and 13:45 - 15:00


P001 Screening for therapeutic compounds to treat eIF2B-related disorders
R. Alves de Almeida and G. Pavitt
P003 The translationally controlled tumour protein TCTP is not rate-limiting for amino-acid-dependent regulation of the mammalian TORC1 pathway
X. Wang, U.-A. Bommer and C.G. Proud
P005 Herpes simplex virus 1 infection induces phosphorylation of PABP1
M. Brook, O. Larralde-Diaz, R. Smith, N.A. Morrice, S. Graham and N.K. Gray
P007 Multiple KH domain-containing proteins antagonise eIF2B in vivo
D. Burgess and G.D. Pavitt
P009 eIF2/eIF2B bodies and their control in translation initiation and cell physiology
S.G. Campbell, P. Reid and M.P. Ashe
P011 The application of LC-MS-MS to study translation initiation complexes and their altered modification status in glucose-replete and -deplete yeast cells
L.M. Castelli, P.F. Sims and M.P. Ashe
P013 Expansion of the proteome by use of alternative initiation codons
M.J. Coldwell, D.R. Damerell and S.J. Morley
P015 Conformational breathing of 40S-eIF1A probed via Maximum Likelihood refinement methods
L. De Colibus, H. Aspeling-Jones, Y. Gordiyenko, T. von der Haar, J. McCarthy and R.J.C. Gilbert
P017 Investigation into the canonical translation factor requirements of cellular IRESs
H. Dobbyn, K. Spriggs, G. Mayeur, H. Booden, M. Coldwell, T. Hinton, S. Morley, J. Hershey and A. Willis
P019 The role of androgen receptor pathway in transcriptional regulation of DHCR24 gene
J. Drzewinska, L. Pulaski and G. Bartosz
P021 Translational control of 5'TOP (terminal oligopyrimidine tract) mRNAs
P. Garside, M. Bushell and A.E. Willis
P023 The intergenic spacer of the Drosophila Adh-Adhr dicistronic mRNA stimulates internal translation initiation
P. Ramanathan, J. Guo, R.N. Whitehead and S. Brogna
P025 New targets for the Escherichia coli cAMP receptor protein identified in whole-genome studies
K. Hollands, G.S. Lloyd and S.J.W. Busby
P027 Characterizing a novel eIF2–eIF5 complex
M. Jennings and G.D. Pavitt
P029 Studies on the 5' untranslated regions of mRNAs that remain associated with polysomes following UV irradiation
A. Kondrashov, L. Young, H. Tiffany, I. Powley, K. Spriggs, M. Bushell and A.E. Willis
P033 Unwinding the mechanism of frameshifting using antisense oligonucleotides
Z. Lin and I. Brierley
P035 Structural studies of 3'UTR and 3'UTR-binding proteins
E. Malaurie, H. Radford, C. de Moor and J. Emsley
P037 Structural studies of translating ribosomes
C. Mayer, L. Yates, C. Pears, P. Fucini and R.J.C. Gilbert
P039 Analysis of poly(A) tail changes by poly(A) fractionation
H.A. Meijer, M. Bushell, K. Hill, T.W. Gant, A.E. Willis, P. Jones and C.H. de Moor
P041 Identifying sites of phosphorylation on the eukaryotic initiation factor-2B
S.S. Mohammad-Qureshi and G.D. Pavitt
P043 Termination codon readthrough in murine leukaemia virus: a role for rpS15a?
S. Napthine and I. Brierley
P045 Mechanistic studies of programmed ribosomal frameshifting
E. Nikolic, C. Mayer, J. Flanagan, R. Gilbert and I. Brierley
P047 Topo-IIa controls the kinetics of reactivated rRNA gene transcription
K.I. Panov, T.B. Panova, J. Russell and J.C.B.M. Zomerdijk
P049 A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor eIF2B
X. Wang and C.G. Proud
P051 Negative regulation in the Escherichia coli mel operon: evidence for DNA wrapping by regulator protein MelR
S. Rodrigo, D. Grainger, M. Elrobh and S. Busby
P053 Coupling of transcription and translation in human mitochondria
J. Rorbach, R.N. Lightowlers and Z.M.A. Chrzanowska-Lightowlers
P055 Transcription from the Xenopus gata2 promoter is dependent on both a CCAAT box sequence and an A-form DNA structure
K. Llewellyn, P.D. Cary, M.J. Guille and G.P. Scarlett
P057 The effect of disease-causing mutations on the function of the transcription factor IRF6
L.-I. Su, H. Little, M. Dixon and P. Shore
P059 SUMO modification of the ETS-domain transcription factor PEA3 is important for its transcriptional activation properties
B. Guo and A. Sharrocks
P061 The role of scavenger decapping enzymes in surviving cellular stress
A. Stevenson, K. Sidaway, F. Salway, P. Day and J. McCarthy
P063 The role of TFIIB phosphorylation in transcription regulation
Y. Wang, J.A. Fairley and S.G.E. Roberts
P065 Reprogramming of translation in C2C12 myoblasts during differentiation
M. Willett, J. McDonald and S. Morley

27 March 2008

Poster Session 2: 13:45 - 15:00 and 17:45 - 19:00


P002 Expression patterns of the poly(A)-binding proteins in mammalian gonads
R. Anderson, H. Burgess, S. MacPherson, M. Millar, M. Brook, I. Adams and N. Gray
P004 The identification of the internal ribosome entry segment (IRES) trans-acting factors of the cyclinT1 and set7 apoptotic IRESs
H. Booden, H. King, M. Bushell, K. Lilley and A. Willis
P006 Modulation of transcription by a nucleoprotein assembly: regulation of the nir operon promoter in enteric bacteria
D.F. Browning, J.A. Cole and S.J.W. Busby
P008 Exploring expression of mammalian poly(A)-binding proteins
H.M. Burgess, M. Brook and N. Gray
P010 Co-operation between WT1 and BASP1 in podocyte differentiation
H. Campbell, L. Green and S. Roberts
P012 Identification of internal ribosome entry segment (IRES) trans-acting factors for the Myc family of IRESs
L.C. Cobbold, K.A. Spriggs, S.J. Haines, H.C. Dobbyn, K.S. Lilley, M. Bushell and A.E. Willis
P014 A link between mRNAs translationally-controlled by eIF4E-binding proteins and specific PUFs
A.G. Cridge, J.B. Smirnova, J.N. Selley, S. Hubbard, J.E.G. McCarthy, M.P. Ashe, C.M. Grant and G.D. Pavitt
P016 The role of Mbd2 in immune system gene regulation
A.M. Deaton, J.R. Grainger, D. Brownstein, H. Owen and A. Bird
P018 Tetra-cysteine tagging of RNA decay pathway components
S. Drummond, A. Stevenson, C. Tang, D. Jackson and J. McCarthy
P020 Structural studies of stalled ribosomes undergoing translocation
J.F. Flanagan IV, S. Moran, O. Namy, D.I. Stuart, I. Brierley and R.J.C. Gilbert
P022 Functional studies of BASP1, a WT1 transcriptional co-suppressor
S.J. Goodfellow and S.G.E. Roberts
P024 Translational profiling of non-Hodgkin’s lymphoma
K. Hill, L. Chaplin, P. Goodrem, T. Gant, M. Bushell and A. Willis
P026 mRNA localization in stress-induced mRNP granules
N.P. Hoyle, S.G. Campbell and M.P. Ashe
P028 Evaluating potential biomarkers from profiling protein and gene expression changes during chemotherapeutic induction using time-of-flight mass spectrometry and microarray
T. Khan and S. el-Tayeb
P030 MicroRNA-mediated translational repression is dependent upon the nuclear history of the message
Y.W. Kong, C.H. de Moor, A.E. Willis and M. Bushell
P032 Molecular basis of a CRP-FNR transcriptional regulator: how CprK controls halorespiration
C. Levy, K. Pike, D. Heyes and D. Leys
P034 The expression of the Wilms’ tumour suppressor protein (WT1) within the human uterus of fertile and infertile women
K. Lucas, L. Thackery, D. Gonzalez, L. Joels, J. White and S. Conlan
P036 Identifying androgen receptor cofactors using oligonucleotide scaffolds
C. Massie, B. Adryan, N. Barbosa-Morais, A. Lynch, M. Tran, D. Neal and I. Mills
P038 Identification and analysis of post-transcriptional limitations during recombinant protein production in mammalian cells
E.J. Mead, L.M. Chiverton, T. von der Haar and C.M. Smales
P040 Direct activation of the Brf1 subunit of TFIIIB by protein kinase CK2
L.E. Mitchell and R.J. White
P042 Dissecting the DNA-binding and regulatory properties of ParB homologue KorB of IncP1 broad host range plasmid RK2
S.T. Muntaha and C.M. Thomas
P044 Novel roles for the exoribonuclease pacman in epithelial sheet sealing
D.P. Grima, M.V. Zabolotskaya, C.I. Jones and S.F. Newbury
P048 Single-molecule experiments investigating DEAD-box helicases and their role in cellular disease
N. Phillips, K. Spriggs and S. Allen
P050 Locating sites of interaction between eIF2B subunits
P.J. Reid, C. Holtby and G.D. Pavitt
P052 ATP-dependent chromatin remodelling factors and Dictyostelium chemotaxis
B. Rogers, M. Keim-Reder, D. Proctor, A. Mueller-Taubenberger and A. Harwood
P054 Translational regulation by polypyrimidine-tract-binding protein: identification of novel targets by RNA interference and cDNA microarray
K. Sawicka, K. Spriggs, M. Bushell and A.E. Willis
P056 The EBV transcription factor EBNA 3C disrupts the cell cycle by up-regulating RGC-32
S. Schlick, H. Webb, C. Banwell, A. Gunnell and M.J. West
P058 Put3p phosphorylation modulates proline-independent activation of PUT1
M.K. Leverentz and R.J. Reece
P060 Characterization of transcription factor modification by SUMO
J.M. Witty, S.H. Yang and A.D. Sharrocks
P062 Functional and interaction analyses of the human protein encoded by the interferon-responsive gene ISG95
T.H. Vaz, T.C.L. Silva and N.I.T. Zanchin
P064 Localization of interactions between components that make up the yeast GAL genetic switch
R. Wightman, R.A. Bell and R.J. Reece