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Annual Symposium - Biochemical Determinants of Tissue Regeneration

11—13 December 2013

Shrigley Hall Hotel, Macclesfield, UK (15 miles from Manchester)

Meeting background

The field of regenerative medicine offers tantalising hope for the repair and replacement of damaged organs and tissues, with the ultimate goal of restoring normal tissue function.  This field represents an enormous range of biological, chemical and biophysical technologies that harness the restorative properties of living materials, especially human cells, to produce new molecular and cellular medicines, diagnostics, devices and healthcare research tools.


The goal of this Biochemical Society Annual Symposium is to explore the key biochemical determinants of tissue regeneration.  We aim to highlight the contribution of biochemistry to this emerging field of regenerative medicine.  We also hope to foster new collaborations among regenerative medicine scientists, clinicians, and bioengineers under the auspices of the Biochemical Society.


Adam Giangreco (University College London, United Kingdom)
Catherine Merry (University of Manchester, United Kingdom)
Wednesday 11 December 2013
09:00 - 11:30 Conference Registration

11:35 - 11:50 Welcome and Meeting Opening

Biochemical Regulation of Tissue Regeneration

John Connelly (Queen Mary, University of London, United Kingdom)
Wednesday 11 December 2013
11:50 - 12:30
Reprogramming as a paradigm for understanding development, cell therapy and cancer
David Tosh (University of Bath, United Kingdom)
12:30 - 13:10
Mechanics and tissue morphodynamics
Enrique Amaya (University of Manchester, United Kingdom)
13:10 - 15:40 Lunch and Poster Session

15:40 - 16:20
Biochemical mechanisms underlying vertebrate limb regeneration
Jeremy Brockes (University College London, United Kingdom)
16:20 - 17:00
Smart cells/dumb scaffolds-epithelial tissue engineering made simple
Sheila MacNeil (University of Sheffield, United Kingdom)
17:00 - 17:20
Quantitative proteomic determination of the cell surface markers of human multipotent mesenchymal progenitor cells
Selected oral communication - Rebecca Holley (University of Manchester, United Kingdom)
17:20 - 18:40 Dinner

18:45 - 19:45
Keynote speaker
Healing the body with materials
Molly Stevens (Imperial College London, United Kingdom)
19:45 - 21:00 Q&A Panel Discussion
The present and future of tissue regeneration

Interventional Regenerative Medicine and Biochemistry

David Tosh (University of Bath, United Kingdom)
Thursday 12 December 2013
09:30 - 10:10
Engineering tissue for the foetus: stem cells and matrix signalling
Paolo De Coppi (University College London, United Kingdom)
10:10 - 10:50
Hepatic progenitor cells in liver repair
Stuart Forbes (University of Edinburgh, United Kingdom)
10:50 - 11:10 Coffee/Tea Break

11:10 - 11:50
Lineage potential and plasticity of epithelial stem/progenitor cells
Paola Bonfanti (Vrije Universiteit Brussel, Belgium)
11:50 - 12:10
Determination of Wnt/beta-catenin driven lung repair processes in mouse and human lung tissue cultures ex vivo
Selected oral communication - Franziska Uhl (Comprehensive Pneumology Centre Munich, Germany)
12:10 - 12:30
Clinical transplantation of allogeneic veins tissue-engineered from autologous peripheral whole blood
Selected oral communication - Suchitra Sumitran-Holgersson (University of Gothenburg, Sweden)
12:30 - 14:30 Lunch and Women in Biochemistry discussion

Bioengineering, Biomaterials and Tissue Regeneration

Weian Zhao (University of California, U.S.A.)
Thursday 12 December 2013
14:30 - 15:10
Cell-matrix signalling and epidermal stem cell fate determination
John Connelly (Queen Mary, University of London, United Kingdom)
15:10 - 15:50
Microenvironmental regulation of fibrillin microfibril deposition
Cay Kielty (University of Manchester, United Kingdom)
15:50 - 16:10
Regenerative effects of adipose tissue derived stem cells for treatment of peripheral nerve injuries
Selected oral communication - Paul J Kingham (Umeå University, Sweden)
16:10 - 16:30 Coffee/Tea Break

16:30 - 17:10
High molecular weight hyaluronan as a mediator of cancer resistance and longevity in the naked mole rat
Adam Giangreco (UCL, United Kingdom)
17:10 - 17:50
Freddy Radtke (EPFL Lausanne, Switzerland)
17:50 - 18:10
Adrenomedullin Haploinsufficiency Predisposes to Secondary Lymphedema
Selected oral communication - Leonid Nikitenko (UCL Cancer Institute, United Kingdom)
18:10 - 18:30
Combining biomaterials and glycosaminoglycans to promote the chondrogenic differentiation of human mesenchymal stem cells
Selected oral communication - Bethanie Ayerst (University of Manchester, United Kingdom)
18:30 - 19:30 Drink Reception

19:30 Conference Dinner

Regener-ageing and Biochemistry

Stuart Forbes (University of Edinburgh, United Kingdom)
Friday 13 December 2013
09:30 - 10:10
Cellular signalling pathways in immune ageing and regeneration
Richard Aspinall (Cranfield University , United Kingdom)
10:10 - 10:50
Lgr5 stem cells in self-renewal and cancer
Marc van de Wetering (Hubrecht Institute, Netherlands)
10:50 - 11:10
Lineage tracing in humans reveals stochastic homeostasis of airway epithelium resulting from neutral competition of basal cell progenitors
Selected oral communication - Vitor Teixeira (Lungs for Living Research Centre, United Kingdom)
11:10 - 11:30 Coffee/Tea Break

11:30 - 12:10
New insights into skin stem cell aging and cancer.
Bill Keyes (Centre for Genomic Regulation, Spain)
12:10 - 12:50
Modeling intestinal stem cell organization in silico.
Jörg Galle (University of Leipzig , Germany)
12:50 - 14:00 Lunch

Hot Topics in Tissue Regeneration

Bill Keyes (Centre for Genomic Regulation, Spain)
Friday 13 December 2013
14:00 - 14:40
Synthetic molecules and materials to stimulate tissue regeneration
Kevin Shakesheff (The University of Nottingham, United Kingdom)
14:40 - 15:00
In vivo reprogramming to pluripotency as a strategy for tissue regeneration
Selected oral communication - Irene de Lazaro (University College London, United Kingdom)
15:00 - 15:40
Novel bioengineered tools for cancer detection and treatment
Weian Zhao (University of California, U.S.A.)
15:40 - 16:00 Summary and end of conference