Organizers:
Jenni Harvey (University of Dundee, UK)
Chris Connolly (University of Dundee, UK)
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Excitation/inhibition on behaviour
Chair:
Trevor Smart (University College London, UK)
12:00 - 13:25 Registration
Please note that lunch on Tuesday is not included in the registration fees and can be purchased from the canteen on the ground floor of the Gateway Building
Glutamate receptors in hippocampus-dependent learning and memory
David Bannerman (University of Oxford, UK)
Role of GABAA receptors in cognition
Hanns Möhler (University of Zürich, Switzerland)
Positive allosteric activation of GABA-A receptors bi-directionally modulates hippocampal glutamate plasticity and behavior
Selected oral communication - Elizabeth Tietz (University of Toledo, USA)
15:10 - 15:40 Coffee and tea break
A-to-I RNA editing regulates the expression of the GABAA receptor
Selected oral communication - Marie Öhman (Stockholm University, Sweden)
The functional significance of extrasynaptic GABAA receptor expression
Stephen Brickley (Imperial College London, UK)
The unique role of α5GABAA receptors in regulating synaptic plasticity and memory
Beverley Orser (University of Toronto, Canada)
17:20 - 18:30 Dinner at New Hall
18:45 - 21:00 Drinks reception at the Bell Pettigrew Museum of Natural History, Bute Buildings, University of St Andrews
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Receptor structure and function
Chair:
Jenni Harvey (University of Dundee, UK)
Use of concatamers to study GABAA receptor architecture and function
Erwin Sigel (University of Bern, Switzerland)
Unnatural ways of studying GABA receptors
Sarah Lummis (University of Cambridge, UK)
10:20 - 10:50 Coffee and tea break
NMDA receptor structure-function studies: agonists, partial agonists and chimeric proteins
David Wyllie (University of Edinburgh, UK)
Locating the RDL GABA receptor agonist binding site
Selected oral communication - Ian McGonigle (University of Cambridge, UK)
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Receptor trafficking
Chair:
David Wyllie (University of Edinburgh, UK)
Dynamic modulation of neuronal inhibtion and behavior by GABAA receptor phosphoryaltion
Steve Moss (University of Pennsylvania, USA)
Inhibitory synaptic plasticity
Trevor Smart (University College London, UK)
15:20 - 15:50 Coffee and tea break
Glutamate receptors and calcium sensors in synaptic plasticity
Graham Collingridge (University of Bristol, UK)
Regulation of glutamate receptor trafficking by leptin
Jenni Harvey (University of Dundee, UK)
17:10 - 19:15 Poster session and "Meet the Speakers" event
19:15 - 20:15 Dinner at New Hall
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Activity dependent changes in gene expression
Chair:
Chris Connolly (University of Dundee, UK)
Regulation of NMDA receptor calcium signaling by protein kinases
R. Suzanne Zukin (Albert Einstein College of Medicine, NY, USA)
Ca-dependent regulation of GABA and NMDA receptors: implication to function of tripartite synapse
Selected oral communication - Yuriy Pankratov (University of Warwick, UK)
Activity-dependent gene transcription, as a long-term influence on receptor signalling
Brian Morris (University of Glasgow, UK)
11:00 - 11:30 Coffee and tea break
Synaptic evolution, molecular networks and the emergence of behaviour
Seth Grant (Wellcome Trust Sanger Institute, UK)
Suppressing Tonic Inhibition In Vivo Mediates Post-Stroke Functional Improvements
Selected oral communication - Andrew Clarkson (University of California, USA)
12:30 - 17:00 Lunch and free time
17:00 - 17:15 Poster prize awards
The Colworth Medal Lecture
Dichotomous signalling by NMDA receptors to survival and death
Giles Hardingham (University of Edinburgh, UK)
19:30 - 22:00 Conference dinner
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Excitation/inhibition in disease
Chair:
Giles Hardingham (University of Edinburgh, UK)
GABRB2 in schizophrenia and bipolar disorder: disease association, gene expression and clinical correlations
Selected oral communication - Hong Xue (The Hong Kong University of Science & Technology, Hong Kong)
Changes in GABAergic inhibition in temporal lobe epilepsy
Matthew Walker (Institute of Neurology, UK)
The role of PSD-95 in hippocampal long-term depression
Robert Malenka (Stanford University, USA)
The alpha4-beta-delta GABAA receptor, tonic current and hippocampal plasticity
Sheryl Smith (SUNY Downstate Medical Center, USA)
10:50 - 11:10 Coffee and tea break
Spare respiratory capacity, oxidative stress and excitotoxicity
David Nicholls (Buck Institute, San Francisco, USA)
The effect of neuronal swelling and inactivation on neuronal function: Are these responses the good, the bad, or the ugly of neuronal toxicity?
Chris Connolly (University of Dundee, UK)
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