Organizers:
Sharon Tooze (Cancer Research, UK)
Jon Lane (University of Bristol, UK)
Wednesday 8 September 2010
16:00 - 18:00 Registration
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Molecular Mechanisms - part 1
Wednesday 8 September 2010
Mechanistic insights into membrane dynamics in autophagy
Tamotsu Yoshimori - Sponsored by the RMS (Osaka University, Japan)
Cellular and molecular regulation of macroautophagy
Patrice Codogno (University of Paris-Sud, France)
TBC1D14, a RabGAP controlling autophagosome formation
Sharon Tooze (Cancer Research, UK)
Network organization of the human autophagy system
Selected oral communication - Christian Behrends (Goethe University, Germany)
21:30 - 22:30 Drinks reception
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Molecular Mechanisms - part 2
Thursday 9 September 2010
The autophagy core-complex regulation in physiological and pathological conditions
Francesco Cecconi (University of Rome, Italy)
Mechanism of autophagosomes biogenesis – Essential role for different mammalian Atg8s
Zevi Elazar (Weizmann Institute, Israel)
Traffic and function of mammalian Atg9
Selected oral communication -Andrea Orsi (London Research Institute, UK)
10:20 - 10:50 Coffee/tea break
Mammalian Atg4 function in cell stress and differentiation
Jon Lane (University of Bristol, UK)
Autophagy in cell death and cancer
Kevin Ryan (Beatson Institute, UK)
ULK1 activity is regulated by class III PtdIns 3-kinase, hVps34, and loss of ULK1 expression causes altered cellular phenotypes
Selected oral communication - Olga Abramczyk (Queen's University, Belfast, UK)
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Early Events in Autophagosome Formation
Thursday 9 September 2010
The role of autophagy in clearance of aggregate-prone proteins associated with disease
Anne Simonsen - Sponsored by the BSCB (University of Oslo, Norway)
The role of PI3P in autophagy induction
Nicholas Ktistakis (Babraham Institute, UK)
Human WIPI proteins, PI(3)P and autophagosome formation
Tassula Proikas-Cezanne (University of Tuebingen, Germany)
Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest
Selected oral communication - Ian Ganley (University of Dundee, UK)
17:50 - 19:30 Poster Session 1
21:00 - 22:30 Poster Session 2
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Autophagy and Disease - part 1
DAP1 is a novel substrate of mTOR which negatively regulates autophagy
Adi Kimchi - Sponsored by EMBO (Weizmann Institute, Israel)
Bcl-2-Mediated regulation of Autophagy in mouse physiology
Beth Levine (UT Southwestern Medical Centre, USA)
Small molecule autophagy regulators as therapeutic targets
Selected oral communication - Sovan Sarkar (Whitehead Institute, MIT, USA)
10:20 - 10:50 Coffee/tea break
Regulation of cancer cell autophagy by kinases and phosphatases
Marja Jäättelä (Danish Cancer Institute, Denmark)
Role of autophagy genes in disease susceptibility and innate immunity
Herbert Virgin (Washington University, USA)
Mitophagy in the haematopoietic system
Selected oral communication - Katja Simon (University of Oxford, UK)
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Autophagy and Disease - part 2
Autophagy, a guardian against neurodegeneration
David Rubinsztein (University of Cambridge, UK)
Autophagy and cancer therapy
Andrew Thorburn (University of Colorado, USA)
Activated Ras Requires Autophagy to Maintain Oxidative Metabolism and Tumorigenesis
Eileen White - Sponsored by CRUK (University of Medicine and Dentistry, New Jersey, USA)
Pathogenic role of autophagy in muscular dystrophies linked to collagen VI deficiency
Selected oral communication - Paolo Grumati (University of Padova, Italy)
19:30 - 20:00 Drinks reception
Phosphoinositides in endosomal sorting and signalling
Peter Cullen (University of Bristol, UK)
21:00 - 22:30 Poster Session 3
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Autophagy and homeostasis
Saturday 11 September 2010
Caspase regulation of starvation-induced autophagy in Drosophila
Sharon Gorski (British Columbia Cancer Research Centre, Canada)
Investigating infection-associated autophagy in the rice blast fungus magnaporthe oryzae
Nick Talbot (University of Exeter, UK)
Glycosphingolipid depletion causes abnormal autophagy in C. elegans
Selected oral communication - Giovanni Lesa (University College London, UK)
10:20 - 10:50 Coffee/tea break
Coronaviruses hijack LC3-I-positive EDEMosome membranes for replication
Fulvio Reggiori (University of Utrecht, The Netherlands)
Similarities in autophagic clearance of mitochondria and microbes – more than a mere coincidence?
Vojo Deretic (University of New Mexico Health Sciences Center, USA)
Adaptive autophagy in plasma cells
Selected oral communication - Niccolò Pengo (San Raffaele Scientific Institute, Milan, Italy)
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Ub and targeting
Saturday 11 September 2010
Molecular basis of selective autophagy
Ivan Dikic (Goethe University, Germany)
Regulation of selective autophagy pathways in yeast
Matthias Peter (ETH Zurich, Switzerland)
LC3-interacting proteins involved in selective autophagy and movement of autophagosomes
Terje Johansen (University of Tromso, Norway)
Chaperone-assisted selective autophagy (CASA) is essential for muscle maintenance
Selected oral communication - Jörg Höhfeld (University of Bonn, Germany)
17:50 - 18:30 Drinks reception
AMP-activated protein kinase - a cellular energy sensor acting upstream of mTOR
Grahame Hardie (University of Dundee, UK)
19:30 - 22:00 Conference Dinner
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Nutrient transport and signalling
Amino acid sensing and mTORC1 regulation: an inside story
Deborah Goberdhan (University of Oxford, UK)
The PI3K-PKB-FOXO pathway regulates autophagy through modulation of glutamine metabolism
Selected oral communication - Pernilla Eliasson (University Medical Center, Utrecht, The Netherlands)
Nutrient control of cell size at division
Selected oral communication - Janni Petersen (University of Manchester, UK)
10:10 - 10:40 Coffee/tea break
Starving cancer cells to death
Aimee Edinger (University of California - Irvine, USA)
Convergence of developmental, nutrient and stress signaling in autophagy regulation
Tom Neufeld (University of Minnesota, USA)
11:50 - 12:00 Closing remarks
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