Timetable
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Joint 62nd Harden Conference/EMBO Symposium - NO; a radical in control. The biological diversity of nitric oxide metabolism and signalling
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NO chemistry and metabolism (1)
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Session 1
Chair:
Chris Cooper (University of Essex, UK)
13:30 - 16:45 Conference Registration
16:45 - 17:00 Introduction
Nitric oxide biochemistry - across biological kingdoms
Chris Cooper (University of Essex, UK)
NO and Her Children in the Biological Milieu: Chemical and Physical Determinants of Action
Jack Lancaster (University of Alabama at Birmingham, USA)
21:00 - 22:00 Wine Reception
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Session 2
Chair:
Rafael Radi (Universidad de la Republica, Uruguay)
13:30 - 16:45 Conference Registration
16:45 - 17:00 Introduction
NADPH oxidases determine nitric oxide level and activity
Guy Brown (University of Cambridge, UK)
NO news is bad news - how bacteria cope
Robert Poole (University of Sheffield, UK)
The role of mitochondria in the bioactivation of nitroglycerin and nitrite
Bernd Mayer (University of Graz, Austria)
21:00 - 22:00 Wine Reception
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NO chemistry and metabolism (2)
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Session 3
Chair:
Rakesh Patel (University of Alabama at Birmingham, USA)
Peroxynitrite biochemistry: reaction mechanisms, preferential targets and biological significance
Rafael Radi (Universidad de la Republica, Uruguay)
The assessment of nitration and nitrosation reactions in vivo
Kevin Moore (University College London, UK)
Identiciation of the reaction product of ascorbate and nitrite as a potential repository of NO in vivo
Selected oral communication - Milos Filipovic (University of Belgrade, Serbia and Montenegro)
10:20 - 11:50 Coffee/tea and Poster Session
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Session 4
Chair:
Bernd Mayer (University of Graz, Austria)
13:00 - 16:30 Coach trip to Bourton on the Water
Why NO is a biochemical T.A.R.D.I.S! Lessons from babies and invertebrates
Andrew Gow (Rutgers University, USA)
Nitric oxide scavenging is an essential function of plant haemoglobin
Selected oral communication - Kim Henrik Hebelstrup (University of Aarhus, Denmark)
Nitric oxide modifies thiols in the platelet integrin aIIbb3 as revealed by Raman spectroscopy
Selected oral communication - Sarah O'Neill (Royal College of Surgeons in Ireland, Ireland)
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Session 5
Chair:
Kevin Moore (University College London, UK)
13:00 - 16:30 Coach trip to Bourton on the Water
Red Cells, hypoxia and nitrite constitute a functional system for regulating blood flow in health and disease
Rakesh Patel (University of Alabama, USA)
NO reserve in the microcirculation
Phil James (Cardiff University, UK)
Discussion and drinks - SNO and HbNO measurements (Phil James and Rakesh Patel)
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Session 6
Chair:
Dennis Stuehr (Lerner Research Institute, USA)
Nitrite-dependent NO production pathway in plants
Hideo Yamasaki (University of the Ryukyus, Japan)
Ppseudomonas Aeruginosa nitrite reductase: Catalytic and regulatory mechanisms
Francesca Cutruzzola (University of Rome, Italy)
Defining the Proton Conducting "E-Channel" in a Bacterial Nitric Oxide Reuctase
Selected oral communication - Faye Thorndycroft (University of East Anglia, UK)
10:20 - 12:00 Coffee/tea and poster session
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Session 7
Chair:
Francesca Cutruzzola (University of Rome, Italy)
13:30 - 16:30 Afternoon activities
Nitric oxide interactions with copper containing oxidases
Michael Wilson (University of Essex, UK)
The bacterial cytochrome bd oxidase and nitric oxide
Selected oral communication - Elena Forte (University of Rome ¿La Sapienza¿, Italy)
A novel non-haem iron centre senses nitric oxide in Escherichia coli NorR.
Selected oral communication - Nicholas Tucker (John Innes Centre, UK)
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Session 8
Chair:
Alan Wallace (AstraZeneca, UK)
13:30 - 16:30 Afternoon activities
Catalysis and Regulation in the NO synthases
Dennis Stuehr (Lerner Research Institute, Cleveland Clinic, USA)
Nitric Oxide Synthesis and Regulation in Plants
Nigel Crawford (University of San Diego, USA)
Discussion and drinks - NO synthesis across kingdoms (Dennis Stuehr and Nigel Crawford)
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NO signalling and physiology (1)
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Session 9
Chair:
Valerie O'Donnell (Cardiff University, UK)
Doris Koesling (Bochum University, Germany)
A fundamental role for NO in mediating Ca2+ fluxes in plant cells
David Wendehenne (Université de Bourgogne, France)
Retained sensitivity to NO and male hypertension in sGCalpha1 knockout mice
Selected oral communication - Peter Brouckaert (Ghent University and VIB, Belgium)
10:20 - 11:00 Coffee/tea break
Nitric oxide regulation of lipid signalling
Bruce Freeman (University of Pittsburgh, USA)
Nitric oxide mediation of plant responses to environmental signals
Steven Neill (University of the West of England, UK)
A central role for S-nitrosylation in plant disease resistance
Selected oral communication - Gary Loake (University of Edinburgh, UK)
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Session 10
Chair:
Victor Darley-Usmar (University of Alabama, USA)
Selective iNOS inhibition in pain and inflammation
Pamela Manning (Pfizer, USA)
Lung iNOS: Good guy, bad guy, both or neither?
Richard Knowles (GlaxoSmithKline, UK)
BYK191023, a novel imidazopyridine is a potent and highly selective inhibitor of the inducible nitric oxide synthase in vitro and in vivo
Selected oral communication - Andreas Strub ( ALTANA Pharma AG, Germany)
15:20 - 16:00 Coffee/tea break
Taking control of NO production; the basis of inhibitor binding and selectivity
Alan Wallace (AstraZeneca, UK)
Peroxynitrite-modified collagen-II induced synthesis of NO and other inflammatory mediators in chondrogenically differentiated mesenchymal progenitor cells: Implications for cartilage damage and repair in the diseased human joint
Selected oral communication - Matt Whiteman (National University of Singapore, Republic of Singapore)
Crosstalk between nitric oxide and cyclooxygenase isoforms in the vasculature
Valerie O'Donnell (Cardiff University, UK)
Modulation of vascular tone by neutrophils in vivo
Selected oral communication - Jonathan Morton (Cardiff University, UK)
19:00 - 21:30 Wine and Banquet Dinner
21:30 - 23:30 Live music by Ben & Rachel (The Tithe Barn)
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NO signalling and physiology (2)
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Session 11
Chair:
Bruce Freeman (University of Alabama, USA)
Protein-protein interactions of mitochondrial nitric-oxide synthase
Cecilia Giulivi (University of California - Davis, USA)
Mitochondria as signaling organelles in the vascular endothelium
Selected oral communication - Sergio Colombo (University College London, UK)
Altered gene expression by NO involves a zinc-dependent activation of transcription factors nrf-2 and MTF-1
Selected oral communication - Victoria Kolb-Bachofen (Heinrich-Heine-University, Germany)
7402 The interaction of mitochondria with reactive oxygen and nitrogen species and the role in cell signaling
Victor Darley-Usmar - Lecture sponsored by Waters Ltd (University of Alabama at Birmingham, USA)
S-Nitrosothiol Depletion in Amyotrophic Lateral Sclerosis
Joan Mannick (University of Massachusetts, USA)
11:45 - 13:30 Lunch and conference end
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