Special Events
Kiyoshi Nagai (Cambridge)
Wednesday 20 December 2000
Sir Frederick Gowland Hopkins Memorial Lecture
Timetable
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Fatty Acid Oxidation & Ketone Body Metabolism
Host/Regulation & Metabolism Group/Molecular Enzymology Group Colloquium - In honour of Dr Derek Williamson
Organizers:
Victor A Zammit (Ayr)
Rona R Ramsay (St Andrews)
Sponsors:
R A Laboratories Limited
Lonza GmbH (sponsors of Pre-doctoral Meeting afternoon session)
Pharma Nord (UK) Ltd (sponsors of Pre-doctoral Meeting)
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Fatty acid metabolism I
Chair:
Rona Ramsay (St Andrews)
Introduction and overview: New advances in the understanding of the role of steroids and steroid receptors in disease
Crystal structures of peroxidase high oxidation state intermediates
Travels with CPT1 - from liver to germ cell with stops in between
Environmental oestrogens modify endogenous steroid metabolism - is there a role for these compounds in hormone-dependent cancer therapy?
Chris Kirk (Birmigham, UK)
Plant peroxidases: Structures of substrate complexes and their mechanistic implications
Michael Gajhede (Copenhagen)
CPTI and control of myocardial beta-oxidation flux
Catalase versus peroxidase activity. Towards understanding the bifunctional activity of catalase-peroxidase
Guenther Regelsberger (Vienna)
Alternatives to oestrogen receptor-dependent mechanisms in disease prevention by genistein TGFß action
Alterations in malonyl CoA control of fatty acid oxidation in the ischemic heart
Kiyoshi Nagai (Cambridge)
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Fatty acid metabolism II
Chair:
Patti A Quant (Cambridge, UK)
Androgen receptor and Kennedy's Disease
Engineering Chloroperoxidase for Enhanced Biocatalytic Activity
Functions and dysfunctions of peroxisomal fatty acid alpha- and beta-oxidation systems in man
Microsomal malonyl-CoA-sensitive carnitine acyltransferase
E David Saggerson (London)
Engineering the active site of ascorbate peroxidase
Role of steroids in oxytocin physiology
Directed evolution of a fungal peroxidase and pathway engineering to boost heme expression in a fungal host
Joel Cherry (Novozymes Biotech Inc)
Resistance to thyroid hormone and PPARy resistance
Krishna Chatterjee (Cambridge)
Fuel Sensing Mechanisms integrating Lipid and Carbohydrate Utilisation
A Tribute to the Scientific Life and Work of Derek H Williamson
G Gibbons, M Stubbs, E Newsholme, R Evans
Lignin peroxidase structure and function
Understanding oestrogenicity: the way forward
A new versatile peroxidase from Pleurotus
17:00 - 18:30 Poster Session
17:00 - 17:20 Discussion and close
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Fatty acid metabolism III
Chair:
Simon Eaton (London)
Wednesday 20 December 2000
Specificity and mechanism in cytochromes P450
Gordon C K Roberts (Leicester)
Impact of the Intramitochondrial Enzyme organization on Fatty Acid Oxidation
Cytokines and cytokine-receptors in fetal growth and development - an overview
Michael Symonds (Nottingham)
Roles of Heparan Sulfate Proteglycans in Drosophila
Norbert Perrimon (Boston)
Molecular genetic approaches to dissect fatty acid beta-oxidation in Arabidopsis thaliana
Ontogenesis of prolactin and growth hormone receptors in the fetus: implications for tissue differentiation and development
Michael Freemark (Durham, NC)
An old activity in the P450 superfamily; CYP51, and a new story of drugs and resistance
Steven Kelly (Aberystwyth)
Mouse 2 0-sulphotransferase and kidney development
Structure and bioactivity of heparan sulphate from the 2-O-sulphotransferase mutant mouse
A combinatorial mutagenesis approach for plant and animal cytochromes P450: Study of mutants cyp1A1 obtained by segment-directed mutagenesis
Transcriptional regulation in the placenta during normal and compromised fetal growth
Russ Anthony (Fort Collins)
Structure-Function relationships of liver- and muscle-type CPT I
Sir Frederick Gowland Hopkins Memorial Lecture
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The enzymes and regulation of lipid metabolism in peroxisomes
Chair:
David Saggerson (London)
Wednesday 20 December 2000
MUC1, glycans and the cell surface barrier to embryo implantation in human
Electron transfer in human cytochrome P450 reductase
Nigel Scrutton (Leicester)
Prolactin receptor and it's actions: signal transduction pathways as determined by prolactin receptor knockout mice
Paul Kelly (INSERM, Paris)
The role of the carnitine system in peroxisomal fatty acid oxidation
Predicting drug pharmacokinetics in Man from in vitro metabolism studies
Dermot McGinnity (Charnwood, UK)
Prolaction receptor heterogeneity: evidence for differential roles of the long and short forms of the receptor during development
Linda Schuler (Wisconsin)
Further insights in peroxisomal lipid breakdown via alpha- and beta-oxidation
Paul Van Veldhoven (Leuven)
Glycosylation changes during differentiation of the mouse uterine epithelium for implantation of the embryo
Susan J Kimber (Manchester)
Evolution of bioinorganic motifs in P450 systems
Kirill N Degtyarenko (Cambridge, UK)
Regulation of Muc4 in the rat female reproductive tract: Implications for blastocyst implantation
Kermit L Carraway (Miami)
Ontogenesis of leptin expression in placental and fetal tissues during development: does leptin have a functional role?
The clinical consequences of defects in specific peroxisomal beta-oxidation enzymes
Control of electron transfer in nitric oxide synthase
Maturation of cytokine-receptors in preparation for birth
Caroline McMillen (Adelaide)
Peroxisome Proliferator Activated Receptors: Fatty acid sensors in atherosclerosis and cancer
Heperan sulphate in the regulation of bFGF DA Pye
A kinetic model for NO synthase that helps explain relationships between heme reduction, heme-NO complex formation, and NO release
PPARs as physiological sensors of fatty acid metabolism molecular regulation in peroxisomes
17:00 - 18:30 Poster Session
Discussion and close of session
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Regulation and control of lipid metabolism I
Chair:
Jean Girard (CNRS, France)
Thursday 21 December 2000
The role of keratan sulphate chains in the maintenance of corneal transparency
Ian Nieduszynski (Lancaster)
Leptin and its role in pregnancy and fetal development - an overview
Dedication to Derek Williamson
Jean Girard (INSERM, France)
Modeling Human Genetic Disease due to Aberrant Protein Glycosylation: Developmental and Physiologic Abnormalities in the Absence of the Mgat2 Gene
SREBP-1c, a transcription factor involved in the regulation of hepatic glycolytic and lipogenic enzyme gene expresion by the nutritional environment
Leptin secretion from fat cells: role in the growth and development of different fat depots
10:30 - 11:50 Poster Session
Leptin and uncoupling protein gene expression at birth: molecular endpoints of fetal development
Francesc Villarroya (Barcelona)
Glycosaminoglycans in mammalian organogenesis
The hormonal and nutritional regulation of liver CPT I gene transcription
FGF's and FGF receptors in early mouse development
John K Heath (Birmingham, UK)
Fetal and neonatal adipose maturation: a primary site of cytokine and cytokine-receptor action
Terence Stephenson (Nottingham)
Control of neonatal hepatic fatty acid oxidation and ketogenesis by CPT I in health and disease
Patti A Quant (Cambridge)
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Regulation and control of lipid metabolism II
Chair:
Grant Mitchell (Montreal)
Thursday 21 December 2000
FGF's and FGF receptors in early mouse development
John K Heath (Birmingham, UK)
Fetal and neonatal adipose maturation: a primary site of cytokine and cytokine-receptor action
Terence Stephenson (Nottingham)
Post-transcriptional regulation of rat carnitine octanoyltransferase
Fausto G Hegardt (Barcelona)
Physiological and pathological regulation of feto-placental leptin expression
Christoph Fusch (Greifswald)
Regulation of acetyl-CoA carboxylase in the control of fatty acid sythesis and fatty acid oxidation
Molecular defects in leptin and their implications for pregnancy and fetal growth
Sadaf Farooqi (Cambridge)
Proteoglycans in developmental patterning: from growth control to synapse assembly
Fatty acid oxidation and ketogenesis in the brain: rationales, mechanisms and clinical implications
John Edmond, John Clark & John Land (Los Angeles & London)
Heparan sulphate in mouse neural development
Jeremy Turnbull (Birmingham, UK)
Cytokines and the cytokine-receptor superfamily: the future
Peter Gluckman (Auckland)
Discussion and close of colloquium
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Protein Engineering of Peroxidases and Cytochrome P450
Bioenergetics Group Colloquium
Organizers:
Andrew Smith (Sussex)
Thursday 21 December 2000
The role of keratan sulphate chains in the maintenance of corneal transparency
Ian Nieduszynski (Lancaster)
Leptin and its role in pregnancy and fetal development - an overview
Modeling Human Genetic Disease due to Aberrant Protein Glycosylation: Developmental and Physiologic Abnormalities in the Absence of the Mgat2 Gene
Leptin secretion from fat cells: role in the growth and development of different fat depots
10:30 - 11:50 Poster Session
Leptin and uncoupling protein gene expression at birth: molecular endpoints of fetal development
Francesc Villarroya (Barcelona)
Glycosaminoglycans in mammalian organogenesis
FGF's and FGF receptors in early mouse development
John K Heath (Birmingham, UK)
Fetal and neonatal adipose maturation: a primary site of cytokine and cytokine-receptor action
Terence Stephenson (Nottingham)
Physiological and pathological regulation of feto-placental leptin expression
Christoph Fusch (Greifswald)
Molecular defects in leptin and their implications for pregnancy and fetal growth
Sadaf Farooqi (Cambridge)
Proteoglycans in developmental patterning: from growth control to synapse assembly
Heparan sulphate in mouse neural development
Jeremy Turnbull (Birmingham, UK)
Cytokines and the cytokine-receptor superfamily: the future
Peter Gluckman (Auckland)
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Peroxidase
Introduction and overview: New advances in the understanding of the role of steroids and steroid receptors in disease
Crystal structures of peroxidase high oxidation state intermediates
Travels with CPT1 - from liver to germ cell with stops in between
Environmental oestrogens modify endogenous steroid metabolism - is there a role for these compounds in hormone-dependent cancer therapy?
Chris Kirk (Birmigham, UK)
Plant peroxidases: Structures of substrate complexes and their mechanistic implications
Michael Gajhede (Copenhagen)
CPTI and control of myocardial beta-oxidation flux
Catalase versus peroxidase activity. Towards understanding the bifunctional activity of catalase-peroxidase
Guenther Regelsberger (Vienna)
Alternatives to oestrogen receptor-dependent mechanisms in disease prevention by genistein TGFß action
Alterations in malonyl CoA control of fatty acid oxidation in the ischemic heart
Kiyoshi Nagai (Cambridge)
Androgen receptor and Kennedy's Disease
Engineering Chloroperoxidase for Enhanced Biocatalytic Activity
Functions and dysfunctions of peroxisomal fatty acid alpha- and beta-oxidation systems in man
Microsomal malonyl-CoA-sensitive carnitine acyltransferase
E David Saggerson (London)
Engineering the active site of ascorbate peroxidase
Role of steroids in oxytocin physiology
Directed evolution of a fungal peroxidase and pathway engineering to boost heme expression in a fungal host
Joel Cherry (Novozymes Biotech Inc)
Resistance to thyroid hormone and PPARy resistance
Krishna Chatterjee (Cambridge)
Fuel Sensing Mechanisms integrating Lipid and Carbohydrate Utilisation
A Tribute to the Scientific Life and Work of Derek H Williamson
G Gibbons, M Stubbs, E Newsholme, R Evans
Lignin peroxidase structure and function
Understanding oestrogenicity: the way forward
A new versatile peroxidase from Pleurotus
17:00 - 18:30 Poster Session
17:00 - 17:20 Discussion and close
|
Protein engineering of P450s and related systems
Wednesday 20 December 2000
Specificity and mechanism in cytochromes P450
Gordon C K Roberts (Leicester)
Cytokines and cytokine-receptors in fetal growth and development - an overview
Michael Symonds (Nottingham)
Roles of Heparan Sulfate Proteglycans in Drosophila
Norbert Perrimon (Boston)
Ontogenesis of prolactin and growth hormone receptors in the fetus: implications for tissue differentiation and development
Michael Freemark (Durham, NC)
An old activity in the P450 superfamily; CYP51, and a new story of drugs and resistance
Steven Kelly (Aberystwyth)
Mouse 2 0-sulphotransferase and kidney development
Structure and bioactivity of heparan sulphate from the 2-O-sulphotransferase mutant mouse
A combinatorial mutagenesis approach for plant and animal cytochromes P450: Study of mutants cyp1A1 obtained by segment-directed mutagenesis
Transcriptional regulation in the placenta during normal and compromised fetal growth
Russ Anthony (Fort Collins)
Sir Frederick Gowland Hopkins Memorial Lecture
MUC1, glycans and the cell surface barrier to embryo implantation in human
Electron transfer in human cytochrome P450 reductase
Nigel Scrutton (Leicester)
Prolactin receptor and it's actions: signal transduction pathways as determined by prolactin receptor knockout mice
Paul Kelly (INSERM, Paris)
Predicting drug pharmacokinetics in Man from in vitro metabolism studies
Dermot McGinnity (Charnwood, UK)
Prolaction receptor heterogeneity: evidence for differential roles of the long and short forms of the receptor during development
Linda Schuler (Wisconsin)
Glycosylation changes during differentiation of the mouse uterine epithelium for implantation of the embryo
Susan J Kimber (Manchester)
Evolution of bioinorganic motifs in P450 systems
Kirill N Degtyarenko (Cambridge, UK)
Regulation of Muc4 in the rat female reproductive tract: Implications for blastocyst implantation
Kermit L Carraway (Miami)
Ontogenesis of leptin expression in placental and fetal tissues during development: does leptin have a functional role?
Control of electron transfer in nitric oxide synthase
Maturation of cytokine-receptors in preparation for birth
Caroline McMillen (Adelaide)
Heperan sulphate in the regulation of bFGF DA Pye
A kinetic model for NO synthase that helps explain relationships between heme reduction, heme-NO complex formation, and NO release
17:00 - 18:30 Poster Session
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The Glycobiology of Development
Glycobiology Group/British Society for Developmental Biology Colloquium
Organizers:
Jamie Davies (Edinburgh)
Sponsor:
British Society for Developmental Biology
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Steroids, Steroid Receptors and Disease
Hormone Group Colloquium
Organizer:
Helen Wiseman (London)
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New Frontiers in DNA Repair
Nucleic Acids & Molecular Biology Group Colloquium
Organizers:
Alan Lehmann (Sussex)
Sponsors:
Cancer Research Campaign
The XPV (xeroderma pigmentation variant) gene and its product
Recent insights into the biochemical properties of human DNA polymerase iota
Roger Woodgate (Bethesda)
Mutagenesis and translesion replication in eukaryotes
Chris Lawrence - Clontech Speaker (New York)
Kiyoshi Nagai (Cambridge)
Translesional DNA Polymerases involved in mutagenesis
Robert Fuchs (Strasbourg)
Antibody Gene Diversification by Somatic Hypermutation
Michael Neuberger (Cambridge, UK)
Domain Structure, function and localisation of DNA polymerase eta, defective in XP variants
Patricia Kannouche (Sussex)
Inducible repair of UV damaged DNA involves p53, pRb and the transcription coupled repair pathway of nucleotide excision repair
Andrew J. Rainbow (Canada)
Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis
Marijke van Oosten (Netherlands)
A link between DNA mismatch repair and the BCI-2 family of apoptotic refulators
Paula Clements (Manchester)
17:00 - 18:30 Poster Session
Structural characterization of oligodeoxynucleotide adducts derived from the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
Wednesday 20 December 2000
Genomic Integrity in Mammalian Cells: A Key Role for Homologous Recombination
Maria Jasin - CRC Speaker (New York)
Roles of recombination in DNA damage repair
Roland Kanaar (Rotterdam)
Role of Bloom's syndrome helicase in suppression of genomic instability
Sir Frederick Gowland Hopkins Memorial Lecture
Modulation of Stalled Replication Forks by RecG Helicase Promotes Replication Restart
DNA repair and cancer predisposition in cells which lack the breast cancer susceptibility gene, BRCA2
Ashok Venkitaraman (Cambridge, UK)
Xrcc2 is required for genetic stability, embryonic neurogenesis, and viability in mice
Bryan Deans (Oxfordshire)
Functional analysis of the XRCC2 homologous recombination repair gene
DNA binding and hydrolysis catalysed by a flap endonuclease
Jon R. Sayers (Sheffield)
17:00 - 18:30 Poster Session
The role of SUMO-1 modifiction in S.pombe
Resolution of holliday junctions in Archaea: Characterisation of the Hjc resolvase from Methanobacterium thermautotrophicum
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Role of specific cytokines and cytokine receptors in fetal growth and development
Society Special Colloquium
Organizer:
Michael Symonds (Nottingham)
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