Special Events
The Novartis Medal Lecture
Michael Neuberger (MRC LMB, Cambridge, UK)
Workshop - Roche Applied Science
Speed, Accuracy, Reliability. Everything you want from Q-PCR
Peter Stockley (Leeds, UK)
Timetable
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Tetrapyrroles: their Birth, Life and Death
Bioenergetics Group
Organizers:
Martin Warren (London, UK)
Graeme Reid (Edinburgh, UK)
Peter Heathcote (London, UK)
David Richardson (East Anglia, UK)
Structure and function of glutamyl tRNA reductase involved in 5-amino levulinic acid formation
Dieter Jahn (Braunschweig, Germany)
Mutants, metals and mechanism of 5-aminolaevulinic acid dehydratase
Peter Shoolingin-Jordan (Southampton, UK)
The terminal steps of haem biosynthesis
Harry Dailey (Athens, Georgia, USA)
Structural Diversity in Metal Ion Chelation, and the structure of Uro'gen III synthase
Heidi L. Schubert (Salt Lake City, UT, USA)
12:30 - 14:00 Lunch and Posters
The biochemistry and enzymology of chlorophyll biosynthesis
Neil Hunter (Sheffield, UK)
Making light of it: the role of plant haem oxygenases in phytochrome chromophore synthesis
Matthew Terry (Southampton, UK)
Two enzymes for oxygen-dependent and independent decarboxylation of coproporphyrinogen III during bacterial tetrapyrrole biosynthesis
Selected Poster Presentation - G. Layer (Braunschweig, Germany)
An investigation into the mechanism of SirB from Bacillus megaterium - a sirohydrochlorin ferrochelatase
Selected Poster Presentation - Helen Leech (Queen Mary University, London)
Radical journeys catalyzed by coenzyme B12-dependent methylmalonyl-CoA mutase
Ruma Banerjee (Nebraska, USA)
Unravelling Chlorophyll Catabolism in Higher Plants
Bernard Kräutler (Innsbruk, Austria)
Haem degradation in animals and plants
Tim Mantle (Dublin, Ireland)
The Novartis Medal Lecture
Michael Neuberger (MRC LMB, Cambridge, UK)
12:30 - 14:00 Lunch and Posters
Workshop - Roche Applied Science
Speed, Accuracy, Reliability. Everything you want from Q-PCR
Peter Stockley (Leeds, UK)
Cytochrome c maturation: a complex pathway for a simple task?
Lynda Thöny-Meyer (Zürich, Switzerland)
Structure of an unusual haemoprotein involved in thiosulfate oxidation
The coupling of ATP hydrolysis to metal ion insertion into porphyrins by magnesium chelatase
Selected Poster Presentation - Jim Reid (Sheffield, UK)
Cobalamin vitamin B12 biosynthesis in Rhodobacter capsulatus
Selected Poster Presentation - Helen McGoldrick (Queen Mary University, London, UK)
Bacterial cytochrome c nitrite reductase: three-dimensional structure and spectroscopy of the multi-haem enzyme
Peter Kroneck (Konstanz, Germany)
Structure and function of the nickel tetrapyrrole F430 in methanogenic archaea
Rolf Thauer (Marburg, Germany)
A universal mechanism for fumarate reduction
Graeme Reid (Edinburgh, UK)
The resuscitation of two dihaem respiratory enzymes
Nick Watmough (East Anglia, UK)
The denitrification pathway in the hyperthermophile Pyrobaculum aerophilum
Simon de Vries (Delft, The Netherlands)
12:30 - 14:00 Lunch and Posters
The structure and function of purple bacterial antenna complexes
R J Cogdell (Glasgow, UK)
Spectroscopic characterisation of Cytochrome cbb3 oxidase from Pseudomonas stutzeri
Selected Poster Presentation - Robert Pitcher (East Anglia, UK)
The role of membrane bound tetraheme CymA in the anaerobic respiration of Shewanella oneidensis MR-1
Selected Poster Presentation - Carsten Schwalb (Edinburgh, UK)
Crystal structure of formate dehydrogenase N from E. Coli
So Iwata (Imperial College, London, UK)
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Amyloidogenic Proteins Involved in Neurodegeneration and Therapeutic Implications
Protein and Peptide Science Group Related books
Organizers:
Brent Irvine (Belfast, UK)
Brian Austen (London, UK)
The neuropathology of Alzheimer's disease
Ceri Davies (St. George's Hospital Medical School, London, UK)
Protein misfolding and its links with human disease
Chris Dobson (Cambridge, UK)
Three-dimensional structure of amyloid fibrils
Louise Serpell (Cambridge, UK)
Cholesterol and Alzheimer's disease
Benjamin Wolozin (Loyola, IL, USA)
12:30 - 14:00 Lunch and Posters
Memapsin 2  -secretase as a therapeutic target
Jordan Tang (Oklahoma, OK, USA)
Gamma-secretase inhibition
Transgenic models of Alzheimer's disease: behavioural studies and the prospects of therapeutic immunization
Richard Morris (Edinburgh, UK)
Inhibition of toxicity and protofibril formation in the -amyloid peptide (25-35) using N-methylated derivatives
Selected Poster Presentation - Andrew Doig (UMIST, Manchester, UK)
Amyloid fibril formation by human stefin B; influence of solvent composition, trifluoroethanol and temperature
Selected Poster Presentation - Eva Zerovnik (Institute Jozef Stefan, Slovenia)
Polyglutamine conformation in GST-polyglutamine fusion proteins
Selected Poster Presentation - Laura Masino (NIMR, London, UK)
Cell-derived A oligomers: production, activity and inhibition
Dominic Walsh (Harvard, MA, USA)
Properties of neurotoxic peptides related to the BRI gene
Brian Austen (St. George's Hospital Medical School, London, UK)
Oligomerisation and toxicity of alpha-synuclein
Omar El-Agnaf (Lancaster, UK)
The Novartis Medal Lecture
Michael Neuberger (MRC LMB, Cambridge, UK)
12:30 - 14:00 Lunch and Posters
Workshop - Roche Applied Science
Speed, Accuracy, Reliability. Everything you want from Q-PCR
Peter Stockley (Leeds, UK)
Interactions between prion protein isoforms
Byron Caughey (NIAID, Hamilton, MT, USA)
Altering prion protein misfolding for therapy and diagnosis of transmissible Spongiform Encephalopathies
Claudio Soto (Geneva, Switzerland)
The role of poly-glutamine sequences in Huntington's disease
Stephen Davies (University College, London, UK)
Quantitative detection and identification of amyloid beta peptides directly from crude biological samples using the ProteinChip Biology System
Steve Cleverley (Ciphergen)
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Lessons from the Type II Family of G-protein Coupled Receptors; Ligands, Receptor Structure and Function
Hormone Group
Organizer:
David Poyner (Aston, UK)
Transcriptional regulation of the human calcitonin receptor
Mark Pondel (St. George's Hospital Medical School, London, UK)
Corticotrophin releasing hormone receptors: regulation of expression and signalling properties
Edward Hillhouse (Warwick, UK)
Adrenomedullin: receptor and signal transduction
Dave Smith (AstraZeneca, UK)
Identification of the Secretin, VIP and glucagon binding sites: from chimeric receptors to point mutations
Magali Waelbroeck (Brussels, Belgium)
12:30 - 14:00 Lunch and Posters
Additional signals from PAC/VPAC family receptors
Rory Mitchell (Edinburgh, UK)
The structure and function of the GLP-1 receptor
A small sequence in the third intracellular loop of the VPAC1 receptor is responsible for its efficient coupling to the calcium effector
Selected Poster Presentation - Ingrid Langer (Brussels, Belgium)
Transcriptional regulation of the human CRLR in microvascular endothelial cells
Selected Poster Presentation - Leonid Nikitenko (Oxford, UK)
The interaction of cGRP with its receptors
The functional relevance of G protein receptor associated proteins exemplified by the receptor-activity-modifying proteins RAMP
Jan Fischer (Zürich, Switzerland)
Receptor Component Protein (RCP): a member of a multi-protein complex required for G protein-coupled signal transduction
Ian Dickerson (Miami, USA)
Interactions of G protein-coupled receptors with synaptic scaffolding proteins
Hans-Jurgen Kreienkamp (Hamburg, Germany)
The Novartis Medal Lecture
Michael Neuberger (MRC LMB, Cambridge, UK)
12:30 - 14:00 Lunch and Posters
Workshop - Roche Applied Science
Speed, Accuracy, Reliability. Everything you want from Q-PCR
Peter Stockley (Leeds, UK)
In-vitro folding and functional characterization of the extracellular domain of G protein-coupled receptors
Rainer Rudolph (Halle-Wittenberg, Germany)
The development of non-peptide antagonists for calcitonin gene-related peptide receptors
Marcus Schindler (Boehringer Ingelheim Pharma, Germany)
RAMPs interact with and modulate the signalling of VPAC1 receptors
Patrick Sexton (Melbourne, Austrailia)
Bio-informatics and type II GPRCs
Steve Foord (GlaxoSmithKline, UK)
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14-3-3 Proteins in Cell Regulation
Molecular Enzymology Group
Organizer:
Alastair Aitken (Edinburgh, UK)
14-3-3 structure, function and role in neurodegenerative diseases, trafficking and nuclear signalling
Alastair Aitken (Edinburgh, UK)
The molecular architecture of kinase/phosphatase signalling complexes
John Scott (Vollum Institute, Oregon, USA)
Prosurvival function of 14-3-3 proteins
Haian Fu (Emory University, Atlanta, GA, USA)
The Novartis Medal Lecture
Michael Neuberger (MRC LMB, Cambridge, UK)
12:30 - 14:00 Lunch and Posters
Workshop - Roche Applied Science
Speed, Accuracy, Reliability. Everything you want from Q-PCR
Peter Stockley (Leeds, UK)
Structure and function of a cAMP operated 14-3-3 binding switch: essential role in biological timing
David Klein (NIH, Besthesda, MD, USA)
Structure and function of tomato 14-3-3 protein isoforms
Mike Roberts (Lancaster, UK)
Signalling pathways that target diverse plant and human 14-3-3-binding partners
Carol MacKintosh (Dundee, UK)
Use of cerebrospinal fluid 14-3-3 analysis in the diagnosis of sporadic and variant Creutzfeldt-Jakob disease
Selected Poster Presentation - Alison Green (Western General Hospital, Edinburgh, UK)
Analysis of 14-3-3 isoforms in the lateral geniculate nucleus in murine brain
Selected Poster Presentation - Helen Baxter (Edinburgh, UK)
In vivo association of 14-3-3 isoforms with mammalian origins of DNA replication
Selected Poster Presentation - Olivia Novac (McGill, Canada)
IGF-1 induces phosphorylation of two novel residues of FKHR
Selected Poster Presentation - Graham Rena (Dundee, UK)
Multiple roles for 14-3-3 proteins in nucleo-cytoplasmic transport
Mike Yaffe (MIT, Cambridge, MA, USA)
14-3-3 as cruciform-binding DNA replication protein
Maria Zannis-Hadjopoulos (Montreal, Canada)
ExoS binds its co-factor 14-3-3 through a non-phosphorylated motif
Bengt Hallberg (Umea, Sweden)
Transgenic 14-3-3 isoforms in plants
Jan Szopa (Wrocklaw, Poland)
12:30 - 14:00 Lunch and Posters
Phosphorylation-independent interaction between 14-3-3 protein and the plant plasma membrane H+-ATPase
Anja Thoe Fuglsang (Copenhagen, Denmark)
Plants call 14-3-3 for transport assistance
Bert deBoer (Amsterdam, The Netherlands)
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Mediation and Modulation of Antibody Function
Biochemical Immunology Group
Organizer:
Jenny Woof (Dundee, UK)
X-ray crystallographic studies of IgG-Fc  R interactions
Peter Sondermann (Max-Planck Institute, Germany)
Engineering therapeutic antibodies for improved function
Leonard Presta (DNAX Research Institute, Paulo Alto, CA , USA)
IgE Fc structure and receptor interactions
Brian Sutton (King's College, London, UK)
The Novartis Medal Lecture
Michael Neuberger (MRC LMB, Cambridge, UK)
12:30 - 14:00 Lunch and Posters
Workshop - Roche Applied Science
Speed, Accuracy, Reliability. Everything you want from Q-PCR
Peter Stockley (Leeds, UK)
The human IgA-Fc  R interaction and its blockade by streptococcal IgA binding proteins
The contrasting IgG-binding interactions of human and herpes simplex virus Fc receptors
Kathryn Armour (Cambridge, UK)
Novel antibody therapeutics for treatment of cancer and inflammation
Jan van de Winkel (Utrecht, The Netherlands)
Inger Sandlie (Oslo, Norway)
Bispecific antibodies targeting cancer cells
Thomas Valerius (Erlangen, Germany)
Prions: conformations, diagnosis and therapy
Anthony Williamson (Scripps Institute, San Diego, CA, USA)
Formatting antibody fragments to mediate specific therapeutic functions
Neil Weir (Celltech R&D, UK)
Amino acid sequence requirements in the human IgA1 hinge for cleavage by Streptococcal IgA1 proteases
Selected Poster Presentation - B. W. Senior (Dundee, UK)
A single-domain antibody fragment that stabilises the native state of two amyloidogenic lysozyme variants and hence prevents aggregation
Selected Poster Presentation - M. Dumoulin (Cambridge, UK)
Red blood cells (RBC) coated with IgG anti-D bind transforming growth factor-beta (TGF-beta)
Selected Poster Presentation - B. M. Kumpel (Bristol, UK)
Target cytokine delivery to neuroblastoma
Selected Poster Presentation - P. K. Dehal (Dundee, UK)
12:30 - 14:00 Lunch and Posters
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Research Colloquium: Neurodegeneration
Related books
Viruses and dementia, and the role of apolipoprotein E
Matthew A Wozniak (UMIST, Manchester, UK)
Characterisation of thermodynamic diversity between TSE agent strains
Robert Somerville (BBSRC, Edinburgh, UK)
An investigation into the mechanism of toxicity of amyloid-forming proteins and peptides
Stuart Turnbull (Lancaster, UK)
Heparan sulphate binds the aspartic protease ß-secretase and regulates cleavage of APP
Zoe Scholefield (Birmingham, UK)
Does pentosan polysulphate have prophylactic potential for transmissible spongiform encephalopathies
Christine Farquhar (BBSRC, Edinburgh, UK)
Controlled release of cytochrome c from functional brain mitochondria; implications for apoptotic mechanisms in neurodegenerative disease.
Rebecca Clayton (University College London, UK)
Chronic nicotine treatment reduces beta-amyloidosis
Jennifer Court (Newcastle, UK)
Changes in Nestin and AMPA receptors are associated with preconditioning of the mouse cortex by repetitive spreading depression
Paul Chazot (Sunderland, UK)
An investigation in changes in gene regulation and subsequent signal transduction activation after ischemic stroke
Nick Mitsios (Manchester Metropolitan, UK)
Therapeutics for Alzheimer's Disease
Invited Speaker - Thomas Wisniewski (New York, USA)
12:30 - 14:00 Lunch and Posters
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