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Hot Topic: Keeping the engine clean: role of mitophagy in physiology and pathology

6 December 2011

Charles Darwin House, London, UK



Meeting Background

The homoeostasis of mitochondrial network depends on Mitophagy. This is a meticulous biological process by which dysfunctional mitochondria are targeted, degraded and cleared via the autophagic machinery. Mitochondria dictate the energetic balance of the cell acting as a proper 'engine' alongside serving as conduit for other fundamental physiological functions. A rigid mechanism of mitochondrial quality control is therefore essential to preserve the physiological pace of the cell system and the 'cleaning up' duty mediated by Mitophagy is pivotal for this.

 

This Hot Topic Event therefore highlights a subject topical in modern biomedicine by putting together the pinnacles of the world’s science on the subject and providing a complete picture of what is actually known of this fascinating and essential process.

 

This event will be a unique setting for instructive lectures and vibrant discussions to which senior and junior scientists interested in quality control regulation in the context of energy balance should attend and will be warmly welcomed.

 

Organizer:
Michelangelo Campanella (Royal Veterinary College, University of London UCL Consortium for Mitochondrial Research, United Kingdom)
Tuesday 6 December 2011
08:30 - 09:30 Registration with coffee/tea

09:30 - 09:45
Welcome and Introduction
Michelangelo Campanella (Royal Veterinary College, University of London, UCL Consortium for Mitochondrial Research, UK)
09:45 - 10:15
Biochemical and morphological understanding of mammalian Atg9
Sharon Tooze (Cancer Research, United Kingdom)

The origin of mitophagy: why and how

 

Tuesday 6 December 2011
10:15 - 10:45
Type 1 and 2 mitophagy – evidence for different initiators of mitochondrial autophagy
John Lemasters (Medical University of South Carolina, U.S.A.)
10:45 - 11:00
LC3B, ATG5 and ATG12 are involved in mitochondrial quality control after oxidative stress and can mediate cellular longevity
Selected Oral Communication - Marina Jendrach (Goethe University Medical School, Germany)
11:00 - 11:15
A novel mouse model for imaging and quantifying mitophagy
Selected Oral Communication - Lorna Macleod (University of Oxford, United Kingdom)
11:15 - 11:45 Coffee/tea break

Mitophagy: from flags to genes

 

Tuesday 6 December 2011
11:45 - 12:15
Damage control - How the Pink1/Parkin pathway can regulate removal of impaired mitochondria by autophagy
Richard Youle (National Institute of Neurological Disorders and Stroke , U.S.A.)
12:15 - 12:30
Mitochondrial fission/fusion and autophagy proteins in parkin mutant fibroblasts
Selected Oral Communication - Heather Mortiboys (University of Sheffield, United Kingdom)
12:30 - 12:45
Role of PINK1 in mitophagy in dopaminergic neuroblastoma cells
Selected Oral Communication - Judit Jimenez-Sainz (Centro de Investigacion Principe Felipe, Spain)
12:45 - 13:00 Flash poster presentations

13:00 - 14:00 Lunch with Poster Session 1

Mitophagy and mitochondrial dynamics: fusion, fission and segregation

 

Tuesday 6 December 2011
14:00 - 14:30
Excess nutrients interfere with quality control: the case of the pancreatic beta cell
Orian Shirihai (Boston University School of Medicine, U.S.A.)
14:30 - 14:45
Lack of prohibitin-2 induces ß-cell dysfunction and death and promotes diabetes in ß-Phb2-/- mice
Selected Oral Communication - Sachin Supale (University of Geneva, Switzerland)
14:45 - 15:00
Two mutations in OPA1 lead to progressive sensory ataxic neuropathy, stepwise loss of vision, encephalopathy and dysregulated mitophagy
Selected Oral Communication - Joanna Poulton (University of Oxford, United Kingdom)
15:00 - 15:15
Mitochondrial dysfunction in Lysosomal Storage Disorders: Why does Gaucher’s Disease lead to Parkinson’s Disease?
Selected Oral Communication - Laura Osellame (University College London, United Kingdom)
15:15 - 16:00 Coffee/tea break

Mitophagy and cell energy balance: upregulate to regulate

 

Tuesday 6 December 2011
16:00 - 16:30
Mitochondrial elongation during autophagy: a stereotypical response to survive in times of crisis
Luca Scorrano (University of Geneva, Switzerland)
16:30 - 16:45
The mitochondrial Translocator Protein (mTSPO) restricts mitophagy by impinging on core mitochondrial function
Michelangelo Campanella (Royal Veterinary College, United Kingdom)
16:45 - 17:00
Investigating the bioenergetic regulation of Parkin-induced mitophagy
Selected Oral Communication - Thomas MacVicar (University of Bristol, United Kingdom)
17:00 - 17:15
The autophagy genes DRAM1 and p62/SQSTM1 regulate energy metabolism and cell migration/invasion in glioblastoma-initiating cells
Selected Oral Communication - Paolo Salomoni (UCL Cancer Institute, United Kingdom)
17:15 - 17:30
Concluding remarks
Michelangelo Campanella (Royal Veterinary College, University of London UCL Consortium for Mitochondrial Research, United Kingdom)
17:30 - 19:00 Drinks reception with Poster Session 2

19:00 - 19:15 Biochemical Society Centenary Poster Prize Presentation

19:30 Conference Dinner at the Hotel Russell
Attendance is via prepaid ticket only