|
|
Design of Inhibitors for Proteolytic Cascades
Organizers:
Corinne Kay (Organon, UK)
Mike Bird (GlaxoSmithKline, UK)
Augustin Amour (GlaxoSmithKline, UK)
John Deadman (Thrombosis Research Institute, UK)
David Hayes (Upstate, UK)
|
Plenary Lecture
09:00 - 10:00 Registration and coffee
Inhibition kinetics for proteolytic cascades
Robin Leatherbarrow (Imperial College London, UK)
12:30 - 13:30 Lunch and poster viewing
|
MMPs
09:00 - 10:00 Registration and coffee
Biochemistry of matrix metalloproteinases (MMPs): requirements for collagenolytic activity
Hideaki Nagase (Imperial College London, UK)
MMP inhibitors :design from structure
Neera Borkakoti (Medivir UK Ltd, Cambridge, UK)
12:30 - 13:30 Lunch and poster viewing
|
Caspases
09:00 - 10:00 Registration and coffee
Caspase activation and the demolition phase of apoptosis
Seamus Martin (The Smurfit Institute, Dublin, Ireland)
From selective to broad caspase inhibitors
Mike Mortimore (Vertex, UK)
12:30 - 13:30 Lunch and poster viewing
|
Coagulation Factors
09:00 - 10:00 Registration and coffee
12:30 - 13:30 Lunch and poster viewing
Blood coagulation and anticoagulant drug development
John Toomey (GlaxoSmithKline, USA)
Activation of Antithrombin III by Heparin, the synthetic drug Arixtra® and its congeners
Stan van Boeckel (Organon, The Netherlands)
|
Complement Factors
12:30 - 13:30 Lunch and poster viewing
Proteases of the complement system
Rational design of complement inhibitors
John Lambris (Pennsylvania, PA, USA)
15:30 - 16:00 Coffee/tea break
17:00 - 18:00 Poster session with wine and light snacks
|
Emerging Proteolytic Systems
12:30 - 13:30 Lunch and poster viewing
15:30 - 16:00 Coffee/tea break
Proteolytic cascade in amyloidogenesis of Alzheimer's Disease
Brian Austen (St. Georges Hospital Medical School, London, UK)
Function of rhomboid proteases
Matthew Freeman (Cambridge, UK)
17:00 - 18:00 Poster session with wine and light snacks
|