Organizers:
Martin Humphries (Manchester, UK)
Charles Streuli (Manchester, UK)
Linda Green (Manchester, UK)
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Molecular Environment of Integrins including presentation of the Jubilee Lecture
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Structure of Adhesion Signalling
Chair:
David Critchley (Leicester, UK)
Structural basis for ligand recognition by RGD-dependent integrins
Jun Takagi (Osaka, Japan)
Mechanisms of integrin receptor priming, activation and ligand binding
Martin Humphries (Manchester, UK)
Structural studies of ligand recognition by the C-terminus of focal adhesion kinase
Maria Hoellerer (selected poster presentation) (Oxford, UK)
10:15 - 10:45 Coffee/tea break
Structure and function of integrin tail complexes
Bob Liddington (Burnham Institute, La Jolla, CA, USA)
Structural basis for integrin aIIbb3 clustering
Renhao Li (Philadelphia, PA, USA)
Talin FERM domain interactions with PIP kinase type 1g: NMR and fluorescence study
Igor Barsukov (selected poster presentation) (Leicester, UK)
12:30 - 14:00 Lunch and poster session
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Imaging Signalling
Chair:
Ian Hart (John Vane Science Center, London, UK)
12:30 - 14:00 Lunch and poster session
Effect of shear flow on the adhesion and migration of endothelial cells
Benny Geiger (Rehovot, Israel)
Andrew Gilmore (Manchester, UK)
alpha 7 integrin is an essential mediator of sensory nerve regeneration
Natalie Gardiner (selected poster presentation) (Manchester, UK)
15:45 - 16:15 Coffee/tea break
Genetic analysis of integrin alpha-6 beta-4 signalling
Filippo Giancotti (Sloan-Kettering, New York, NY, USA)
Integrin regulation of growth factor signalling in the developing nervous system
Charles ffrench-Constant (Cambridge, UK)
Spatially distinct activation of PAK1 and N-WASP by Cdc42 in breast carcinoma cells
Maddy Parsons (selected poster presentation) (Kings College London, UK)
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Bidirectional Dialogue with Cytoskeleton
Chair:
Charles Streuli (Manchester, UK)
Wednesday 3 December 2003
Talin controls integrin activation
Dave Calderwood (Yale University School of Medicine, New Haven, USA)
Regulation of cell signalling by integrins, growth factor receptors and intracellular adaptors
Paola Defilippi (University of Turin, Italy)
Activation of syndecan-4 reconstitutes cell spreading and triggers dynamic regulation of Rho-family GTPases
Mark Bass (selected poster presentation) (Manchester, UK)
10:15 - 10:45 Coffee/tea break
Integrin regulation of cell signalling and motility
Rudy Juliano (Chapel Hill, NC, USA)
Role of the Src/FAK pathway in cancer
Margaret Frame (Glasgow, UK)
Integrin ECM and cytoskeletal interactions in vivo
Danelle Devenport (selected poster presentation) (Cambridge, UK)
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Jubilee Lecture
Chair:
Martin Humphries (Manchester, UK)
16:00 - 18:00 Registration
Martin Humphries (Manchester, UK)
Targeting the vasculature with novel strategies
Erkki Ruoslahti (Burnham Institute, La Jolla, CA, USA)
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Structure of Adhesion Signalling
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Bidirectional Dialogue with Cytoskeleton
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