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Apoptosis in Myeloid Cells: Molecular Insights into Disease Processes

19—20 November 2003

Chancellor's Building, New Edinburgh Royal Infirmary, Little France, Nr. Edinburgh



Organizers:
Ian Dransfield (Edinburgh, UK)
Adriano Rossi (Edinburgh, UK)
Wednesday 19 November 2003
09:30 - 10:30 Registration and coffee

10:30 - 10:45
Selective induction of inflammatory cell apoptosis and augmented clearance of apoptotic cells by phagocytes: a potential therapeutic target
Adriano Rossi/Chris Haslett (Edinburgh, UK)
10:45 - 11:15
Signalling pathways controlling apoptosis in granulocytes
Edwin Chilvers (Cambridge, UK)
11:15 - 11:45
Tumor-necrosis factor: how many ways to kill your lover
Taco Kuijpers (Amsterdam, The Netherlands)
11:45 - 12:15
Regulation of neutrophil apoptosis by LPS: insights from caspase-1 deficient mice and human cells
Moira Whyte (Sheffield, UK)
12:15 - 12:45
Formation of the CD95 death inducing signalling complex during spontaneous neutrophil apoptosis
Janet Lord (Birmingham, UK)
12:45 - 13:45 Lunch and poster viewing

13:45 - 14:00
Regulation of granulocyte apoptosis by NF-kB activation
Carol Ward (Selected poster presentation) (Edinburgh, UK)
14:00 - 14:15
The response of highly-purified neutrophils to IL-1
Ian Sabroe (Selected poster presentation) (Sheffield, UK)
14:15 - 14:45
Gene profiling in vitro and in vivo models of delayed neutrophil apoptosis: a common pathway?
Bill Watson (Dublin, Ireland)
14:45 - 15:15
An apoptosis differentiation program in human polymorphonuclear leucocytes
Frank De Leo (Massachusetts, USA)
15:15 - 15:45 Coffee/tea break

15:45 - 16:00
What role do caspases play in TNFa stimulated neutrophil apoptosis?
Andrew Cowburn (Selected poster presentation) (Cambridge, UK)
16:00 - 16:15
Early membrane events in neutrophil (PMN) apoptosis: membrane blebbing and vesicles release, CD43 and CD16 down-regulation and phosphatidyl serine externalization
Lise Halbwachs-Mecarelli (Selected poster presentation) (INSERM, Paris, France)
16:15 - 16:45
Regulation of leucocyte survival by PI3K-PKB mediated regulation of FOXO transcription factors
Paul Coffer (Utrecht, The Netherlands)
17:00 - 18:30 Drinks reception and poster session

Thursday 20 November 2003
09:30 - 10:00
Eosinophil apoptosis
Andy Wardlaw (Leicester, UK)
10:00 - 10:30
Mst1 and the regulation of granulocyte death
Patricia de Souza (Imperial College, London, UK)
10:30 - 11:00
Regulation of neutrophil apoptosis by Mcl-1
Steve Edwards (Liverpool, UK)
11:00 - 11:30 Coffee/tea break

11:30 - 12:00
The apoptosome pathway to apoptosis
Seamus Martin (The Smurfit Institute, Dublin, Ireland)
12:00 - 12:15
Mitochondria in apoptosis: past, present and future
Mauro Degli Esposti (Selected poster presentation) (Manchester, UK)
12:15 - 12:30
ATP/P2X7 stimulates macrophage apoptosis and killing of intracellular mycobacteria
Ian Fairbairn (Selected poster presentation) (Edinburgh, UK)
12:30 - 12:45
Mechanisms of induction of neutrophil apoptosis by the Pseudomonas aeruginosa exotoxin pyocyanin
Stephen Bianchi (Selected poster presentation) (Sheffied, UK)
12:45 - 13:00
The role of oxidants and vitamin C in neutrophil apoptosis and clearance
Margret Vissers (Selected poster presentation) (Christchurch, New Zealand)
13:00 - 14:00 Lunch and poster viewing

14:00 - 14:30
The importance of apoptosis in the resolution of acute inflammation
Derek Gilroy (Queen Mary, University of London, UK)
14:30 - 15:00
The importance of resolution of inflammation in the pathogenesis of ANCA-associated vasculitis
Lorainne Harper (Birmingham, UK)
15:00 - 15:30
Annexin 1 and granulocyte apoptosis
Mauro Perretti (William Harvey Research Institute, London, UK)