Biochemical Society - Breakthrough Science - Molecular Structure in Ligand-Gated Ion Channel Function

Molecular Structure in Ligand-Gated Ion Channel Function

Merck Sharp & Dohme, Harlow, UK

Organizers:

Chris Connolly (Dundee, UK)

Keith Wafford (Merck Sharp & Dohme, UK)

Sponsor:

Merck Sharp & Dohme

Thursday 29 January 2004

09:30 - 10:30 Coffee and Registration

10:30 - 11:15

GABA_A receptors: structural determinants of GABA and benzodiazepine recognition

Cynthia Czajkowski (Wisconsin, USA)

11:15 - 12:00

Structural domains underlying the activation and modulation of inhibitory amino acid channels

Trevor Smart (University College London, UK)

12:00 - 12:45

The 5-HT₃ receptor transmembrane domain: residues that control ion selectivity and gating

Sarah Lummis (Cambridge, UK)

12:45 - 14:00 Lunch and Poster Session

14:00 - 14:45

Flexible loops involved in GABA_A and glycine receptor activation

Neil Harrison (Cornell, NY, USA)

14:45 - 15:30

Gating mechanism of the ACh receptor channel

Nigel Unwin (MRC-LMB, Cambridge, UK)

15:30 - 16:00 Coffee/tea break

16:00 - 16:45

The 5-HT₃ receptor reveals an unexpected determinant of single channel conductance

John Peters (Dundee, UK)

16:45 - 17:30

Differentiating the role of GABA_Areceptor subtypes

Keith Wafford (Merck Sharp & Dohme, Harlow, UK)