Timetable
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Session 1
Chair:
Sheila Graham (Glasgow, UK)
RNA interactions of Prp8p in the core of the spliceosome
Andy Newman (MRC-LMB, Cambridge, UK)
Structure-function analysis of the U2 snRNP-associated splicing factor SF3a
Angela Krämer (Geneva, Switzerland)
10:50 - 11:20 Coffee/tea break
Multiple roles of arginine/serine-rich splicing factors in RNA processing
Javier Cáceres (Edinburgh, UK)
Structural dynamics and function of the mammalian spliceosome
Reinhardt Lührmann (Max Planck Institute for Biophysical Chemistry, Göttingen, Germany)
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Session 2
Chair:
Mary O'Connell (Western General Hospital, Edinburgh, UK)
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Novartis Medal Lecture
Structural analysis of the U2-U6 RNA complex
Sam Butcher (Madison, WI, USA)
Mode of action of proteins with RNA chaperone activity
Renée Schroeder (Vienna, Austria)
15:20 - 15:50 Coffee/tea break
Regulation of alternative splicing by PTB and associated factors
Chris Smith (Cambridge, UK)
Presentation of the Novartis Medal
Peter Downes (Dundee, UK)
RNA processing and the Lsm proteins
Novartis Medal Lecture - Jean Beggs (Edinburgh, UK)
17:35 - 19:00 Poster Session (with poster prize awarded by Nature Reviews Molecular Cell Biology)
Meeting Dinner and Ceilidh (Radisson SAS Hotel, Edinburgh)
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Session 3
Chair:
Fritz Eckstein (Göttingen, Germany)
Role of a conserved pseudouridine in recognition of the spliceosomal branch site
Nancy Greenbaum (Florida, FL, USA)
Ribozyme folding and catalysis
David Lilley (Dundee, UK)
10:50 - 11:20 Coffee/tea break
Linkage between proton binding and RNA folding: a thermodynamic framework and its experimental application for investigating pKa shifting
Philip Bevilacqua (Pennsylvania, PA, USA)
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Selected poster presentations
Active site cytosine in the hepatitis delta virus ribozyme provides general acid catalysis (sponsored by Glen Research)
The Glen Lecture - Joseph Piccirilli (Chicago, IL, USA)
The connection between histone pre-mRNA processing factors and cell cycle
Selected poster presentation - Eric Wagner (North Carolina, USA)
Engineered riboswitches to control gene expression by small molecules
Selected poster presentation - Beatrix Suess (Erlangen, Germany)
Specific subsets of mRNA molecules associate with the U2AF65 and PTB splicing factors
Selected poster presentation - Margarida Gama-Carvalho (Lisbon, Portugal)
Hammerhead ribozymes from A. thaliana and D. rerio
Selected poster presentation - Christian Hammann (Kassel, Germany)
Exonic and intronic regulatory elements affect the splicing of human Apolipoprotein AII exon 3 carrying atypical 3¿ splice site
Selected poster presentation - Pablo Arrisi-Mercado (International Centre for Genetic Engineering and Biotechnology, Trieste, Italy)
Structure of the high-affinity manganese(II) binding site in a natural hammerhead ribozyme
Selected poster presentation - Olav Schiemann (Frankfurt/Main, Germany)
15:30 - 16:00 Coffee/tea break
Probing the structure of Saccharomyces cerevisiae RNAse MRP
Selected poster presentation - Johanna Avis (Manchester, UK)
Reverse splicing of a mobile twin-ribozyme group I intron into the natural SSU rRNA insertion site
Selected poster presentation - Steinar Johansen (Tromsø, Norway )
Direct stimulation of translation in vivo: a novel function of herpes simplex virus ICP27 protein
Selected poster presentation - Osmany Larralde (Glasgow, UK)
Modulation of NF1 exon 37 splicing: disease causing mutation changes an ESE into an ESS
Selected poster presentation - Natasa Skoko (Trieste, Italy)
The U6 small nuclear RNA directs exon alignment during pre-mRNA splicing
Selected poster presentation - Ray O'Keefe (Manchester, UK)
Analyzing RNA backbone conformations
Selected poster presentation - Jane Richardson (Duke, Durham, NC, USA)
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Session 4
Chair:
Nicola Gray (Western General Hospital, Edinburgh, UK)
Ribosomal crystallography: from peptide bond formation to cotranslational folding
Ada Yonath (Weizmann Institute, Rehovot, Israel)
Substrate selection and the mechanism of peptide bond formation by the ribosome
Marina Rodnina (Witten/Herdecke, Germany)
10:50 - 11:20 Coffee/tea break
Structure and dynamics in translation
Jody Puglisi (Stanford, CA, USA)
Nuclear RNA degradation by the exosome is promoted by a polyadenylation complex
David Tollervey (Edinburgh, UK)
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Session 5
Chair:
Mike Gait (Cambridge, UK)
Molecular recognition of the ribosomal decoding site by aminoglycoside antibiotics
Eric Westhof (IBNC-CNRS, Strasbourg, France)
Ribozymes as reporters for biomolecular interactions
Michael Famulok (Bonn, Germany)
15:20 - 15:50 Coffee/tea break
Structural basis for Diels-Alder ribozyme catalyzed carbon-carbon bond formation
Andres Jaeschke (Ruprecht Karls University, Heidelberg, Germany)
Interconnecting mRNA 3¿ end processing, transcription and chromatin structure
Nick Proudfoot (Oxford, UK)
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