Organizers:
Anne Ridley (Ludwig Institute of Cancer Research, London, UK)
Miguel Seabra (Imperial College London, UK)
13:30 - 15:00 Registration and coffee/tea
Arf-like GTPases and the organisation of membrane traffic
Sean Munro (MRC-LMB, Cambridge, UK)
Ras plasma membrane signalling platforms
John Hancock (Queensland, Australia)
A de-reacylation cycle regulates the compartmentalised localisation and activity of palmitoylated Ras isoforms
Oliver Rocks - Selected oral communication (EMBL, Heidelberg, Germany)
SAND-1 is an effector of RAB-7 and is required for endocytosis in Caenorhabditis elegans
Dmitry Poteryaev - Selected oral communication (Max Planck Gesellschaft, Tuebingen, Germany)
Protein semi-synthesis and its application to studies of structure and function of Rab GTPases
Kirill Alexandrov (Max Planck Institute of Molecular Physiology, Dortmund, Germany)
17:00 - 18:30 Welcome drinks reception
Caveolin-1 mediates integrin-regulated membrane domain internalization
Miguel Del Pozo (CNIC, Madrid, Spain)
Insights into biological function across species: examining the role of Rab proteins in Yip1p function
Ruth Collins (Cornell, NY, USA)
Membrane curvature and the control of GTP hydrolysis in Arf1 during COPI vesicle formation
Bruno Antonny (CNRS, Valbonne, France)
Palmitoylation and the subcellular localization of Ras proteins
Robert Deschenes (Medical College of Wisconsin, WI, USA)
Uncoupling of inhibitory and shuttling functions of rhoGDIs
Estelle Dransart - Selected oral communication (CNRS, Gif-sur-Yvette, France)
10:15 - 10:45 Coffee/tea break
A role for effectors in Rab localization
Suzanne Pfeffer (Stanford, CA, USA)
Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells
Michiyuki Matsuda (Osaka, Japan)
How ArfGEFs couple stimulation of GDP/GTP exchange to membrane recruitment of Arf proteins
Jacqueline Cherfils - Selected oral communication (CNRS, Gif-sur-Yvette, France)
13:30 - 16:00 Formal poster session and coffee/tea
Localization and function of Arf family GTPases
Julie Donaldson (National Heart, Lung and Blood Institute, MD, USA)
ARL1 and ARF6 have essential roles in Trypanosoma brucei
Helen Price- Selected oral communication (York, UK)
Ran and assembly of the nuclear envelope
Wolfram Antonin (EMBL, Heidelberg, Germany)
Design of a FRET-based biosensor to visualize the spatio-temporal activation of Pak1 kinase in living cells
Maria Carla Parrini - Selected oral communication (INSERM, Paris, France)
18:30 - 23:00 Meeting dinner and social
Regulation of RhoE localization and function
Anne Ridley (Ludwig Institute for Cancer Research, London, UK)
Rab targeting signals and mechanisms
Miguel Seabra (Imperial College London, UK)
A novel mode of GEF-GTPase interaction drives Rac1 targeting d activation by beta-Pix
Jean Paul ten Klooster - Selected oral communication (Sanquin Research, Amsterdam, Netherlands)
10:15 - 10:45 Coffee/tea break
A farnesyl-electrostatic switch regulates K-Ras association with mitochondria and stimulates apoptosis
Mark Philips (New York, USA)
A novel Golgi-localized Cdc42-GAP that functions downstream of ARF1 to control Arp2/3 complex/F-actin dynamics
Philippe Chavrier (Institut Curie, Paris, France)
Activation of endogenous Ras is predominant at the plasma membrane
Ignacio Rubio - Selected oral communication (Friedrich Schiller, Jena, Germany)