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Neurotrophins: mechanisms in disease and therapy

6 April 2006

School of Chemistry, Bristol, UK



Chairs:
David Wynick (University of Bristol, UK)
Stafford L Lightman (University of Bristol, UK)
Organizers:
Shelley Allen (University of Bristol, UK)
David Dawbarn (University of Bristol, UK)
Thursday 6 April 2006
09:00 - 10:00 Registration with coffee/tea

10:00 - 10:10
Welcoming introduction
Shelley Allen (University of Bristol, UK)
10:10 - 10:45
NGF receptor TrkAd5: therapeutic and drug design target
David Dawbarn (University of Bristol, UK)
10:45 - 11:25
Neurotrophins and pain
Steve McMahon (Kings College London, UK)
11:25 - 11:45 Coffee/tea break

11:45 - 12:25
Role of the neurotrophins in energy homeostasis in humans: insights from genetics
Giles Yeo (University of Cambridge, UK)
12:25 - 12:40
Neurotrophins promote angiogenesis. Potential implications for curing limb ischaemic and myocardial infarction
Selected oral communication - Costanza Emanueli (University of Bristol, UK)
12:40 - 12:55
Neuro-immune interaction in allergic asthma: The role of the low-affinity pan-neurotrophin receptor p75NTR
Selected oral communication - Christina Nassenstein (Fraunhofer ITEM, Germany)
12:55 - 14:00 Lunch and poster session

14:00 - 14:40
The contribution of neurotrophins to the pathogenesis of allergic asthma
Armin Braun (Fraunhofer ITEM, Germany)
14:40 - 15:20
Molecular mechanisms and function of BDNF in adult synaptic plasticity
Clive Bramham (University of Bergen, Norway)
15:20 - 15:50 Coffee/tea break

15:50 - 16:05
Structural and functional properties of mouse proNGF
Selected oral communication - Francesca Paoletti (SISSA-ISAS, Italy)
16:05 - 16:45
Mechanisms of neurotrophin receptor signalling
Moses Chao (New York University, USA)
16:45 - 17:25
Development of functional peptidomimetic ligands of Trk and p75 neurotrophin receptors: agonists applied to animal models of degeneration
Uri Saragovi (Lady Davis Institute, Canada)
17:30 - 18:30 Wine reception