Organizers:
Heather Wallace (Aberdeen, UK)
Tony Corfield (Bristol, UK)
Chris Paraskeva (Bristol, UK)
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The Molecular Biology of Colorectal Cancer
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Session 1
Chair:
Tony Corfield (Bristol, UK)
09:00 - 10:00 Registration and coffee/tea
Cancer Research UK Lecture
Signal transduction, stem cell differentiation and genetic instability in colorectal cancer initation and progression: it's all in the game
Cancer Research UK Lecture - Riccardo Fodde (Rotterdam, Netherlands)
Investigating the functional requirement for tumour suppressor genes through conditional deletion in the mouse
Alan Clarke (Cardiff, UK)
11:30 - 12:00 Coffee/tea break
Apoptosis COX-2 and chemoprevention of colorectal cancer
Chris Paraskeva (Bristol, UK)
12:45 - 14:00 Lunch and poster session
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Session 2
Chair:
Heather Wallace (Aberdeen, UK)
12:45 - 14:00 Lunch and poster session
The role of the Wnt signalling pathway in tumorigenesis
Jurgen Behrens (Erlangen, Germany)
The role of the retinoblastoma protein (pRb) in the nuclear localisation of BAG-1: implications for colorectal tumour cell survival
Selected oral communication - Nadine Clemo (Bristol, UK)
Sp3-mediated up-regulation of BAK effects butyrate-mediated apoptosis
Selected oral communication - Hari Chirakkal (Sheffield, UK)
Phosphorylation-dependent interaction between c-Jun and TCF4 is required for efficient colon cancer development in a mouse model
Selected oral communication - Abdolrahman Shams Nateri (Cancer Research UK, London, UK)
15:30 - 15:50 Coffee/tea break
MutYH and colorectal cancer
Julian Sampson (Cardiff, UK)
Targeting IGF-II-mediated signalling in colorectal cancer
Bass Hassan (Bristol, UK)
17:20 - 18:30 Wine Reception
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Session 3
Chair:
Bass Hassan (Bristol, UK)
Epigenetic events in the colorectum in colorectal cancer
Bill Grady (Fred Hutchinson Cancer Research Center, Seattle, WA, USA)
MMR missense mutations and cancer in murine models
Winfried Edelmann (Yeshiva Univeristy, Bronx, NY, USA)
10:30 - 11:15 Coffee/tea break
Relationship between the role of the adenomatus polyposis coli protein in colon cancer and its contribution to cytoskeletal regulation
12:00 - 13:30 Lunch and poster session
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Session 4
Chair:
Ann Williams (Bristol, UK)
10:30 - 11:15 Coffee/tea break
12:00 - 13:30 Lunch and poster session
The nuclear response to Wnt signalling
Mariann Bienz (Cambridge, UK)
Leukotriene D4 induces TCF/LEF activation and association of ß-catenin with Bcl-2 in intestinal epithelial cells
Selected oral communication - Maryna Mezhybovska (Lund, Sweden)
Molecular targets of nitric oxide-donating aspirin (NO-ASA) in cancer
Selected oral communication - Khosrow Kashfi (City University of New York, NY, USA)
Elevated colorectal cancer risk associated with base excision repair defects
Selected oral communication - Susan Farrington (Edinburgh, UK)
15:00 - 15:20 Coffee/tea break
Differential proteome analysis of human colorectal cancer based on a cellular model for the adenoma to carcinoma sequence
Franz Georg Hanisch (Cologne, Germany)
Structure and specificity of GSK3
Laurence Pearl (Institute of Cancer Research, London, UK)
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