Organizers:
Anne Willis (University of Nottingham, UK)
Sarah Newbury (University of Newcastle upon Tyne, UK)
Graham Pavitt (University of Manchester, UK)
Martin Bushell (University of Nottingham, UK)
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Ribosome structure and factor mechanism
Chair:
Graham Pavitt (University of Manchester, UK)
15:30 - 16:30 Registration
Anne Willis (University of Nottingham, UK)
Biophysical studies of the eukaryotic translation initiation pathway
John McCarthy (University of Manchester, UK)
The interplay of initiation factors in ribosomal subunit association
Ayman Antoun (Uppsala University, Sweden)
A cold look on internal initiation of translation: Cryo-EM structures of IRES RNAs bound to ribosomal particles
Christian Spahn (University of Berlin, Germany)
Structural studies of the eukaryotic initiation factor 5 (eIF5)
Sasi Conte (Kings College London, UK)
Discrete cytoplasmic foci represent sites of eIF2 and eIF2B localisation in the yeast Saccharomyces cerevisiae
Susan Campbell (University of Manchester, UK)
ADP-ribosylation by ribosome mimicry
Gregers Rom Andersen (University of Aarhus, Denmark)
19:00 - 20:30 Buffet and poster session
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Control of translation I
Chair:
Matthias Hentze (European Molecular Biology Laboratory, Germany)
The C-terminal domain of eIF1A promotes preinitiation complex assembly, scanning and AUG selection in vivo
Alan Hinnebusch (National Institutes of Health, USA)
Interferon-alpha desensitizes protein synthesis to inhibition by TRAIL in Jurkat lymphoma cells
Androulla Elia (St George¿s, University of London, UK)
Identification and characterisation of mRNAs translated following DNA damage
Ian Powley (University of Nottingham, UK)
Coping with stress: eIF2 kinases and translational control
Ron Wek (Indiana University, USA)
Rescuing translational effects of siRNA-mediated knockdown of eIF4GI
Mark Coldwell (University of Sussex, UK)
Functional characterization of two eIF4A helicases from Trypanosoma brucei
Osvaldo de Melo Neto (CPqAM-FIOCRUZ, Brazil)
11:00 - 11:30 Coffee/tea break
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Control of translation II (control during development)
Chair:
Allan Jacobson (University of Massachusetts, USA)
11:00 - 11:30 Coffee/tea break
Translational control of gene expression during the induction of apoptosis
Martin Bushell (Universisty of Nottingham, UK)
The selective recruitment of secretory protein mRNA to the ER and an increase in initiation are important mediators of glucose stimulated proinsulin synthesis in pancreatic b-cells
Terence Herbert (University of Leicester, UK)
GURB, a potential translational regulator in oocyte development and cell adhesion
Cornelia de Moor (University of Nottingham, UK)
Interaction of paxillin with poly(A)-binding protein 1 regulates cell migration via translational control of Raf-1 synthesis
Jim Norman (University of Leicester, UK)
Mind the gap - a co-translational skip in peptide bond formation and possible recruitment of release factor to a sense codon
Victoria Doronina (University of Newcastle, UK)
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Translational control and disease I
Chair:
Richard Jackson (University of Cambridge, UK)
IRES-dependent regulation of FGF-2 mRNA translation in pathophysiological conditions in mouse
Anne-Catherine Prats (University of Toulouse, France)
Multiple translational controls in the feline immunodeficiency virus
Valentina Camerini (Pisa University, Italy)
Structure and function of the N-terminal RRM domains of PTB
Tom Monie (Imperial College London, UK)
The large clinical spectrum of EIF2B-related diseases
Odile Boespflug-Tanguy (Clermont-Ferrand University, France)
15:50 - 16:20 Coffee/tea break
18:00 - 19:30 Poster session
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Translational control and disease II
Chair:
Martin Bushell (University of Nottingham, UK)
15:50 - 16:20 Coffee/tea break
Role of eIF2B in innate immunity and tumorigenesis
Glen Barber (Miami University, USA)
Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells
Michael Clemens (St George¿s, University of London, UK)
Ca++-stress dependent regulation of the anti-apoptotic translationally controlled tumour protein (TCTP) by the pro-apoptotic dsRNA-dependent protein kinase PKR
Ulrich-Axel Bommer (St George¿s, University of London, UK)
Translational control of Mdr1 during the integrative stress response
Protein synthesis persists during necrotic cell death
Xavier Saelens (University of Gent, Belgium)
18:00 - 19:30 Poster session
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Control of translation by mRNA turnover I
Chair:
Peter Sarnow (Stanford University, USA)
Ribonucleases and their role in Drosophila development
Sarah Newbury (University of Newcastle upon Tyne, UK)
Translational stimulation by EDEN-type class III AU-rich elements
Carine Barreau (University of Rennes, France)
The role of the PNG kinase complex in the translational regulation of mitotic cyclins
Leah Vardy (Massachusetts Institute of Technology, USA)
The DAZL family proteins are PABP binding proteins that regulate translation in germ cells
10:15 - 10:45 Coffee/tea break
Anne Willis (University of Nottingham, UK)
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Control of translation by mRNA turnover II
Chair:
Simon Morley (University of Sussex, UK)
10:15 - 10:45 Coffee/tea break
Linking mRNA decay pathways by decapping
Mike Kiledjian (Rutgers University, USA)
Implications of biological role of m7G-specific HIT nucleotide hydrolase in eukaryots
Naglis Malys (University of Manchester, UK)
Translational control mediated by cis-acting sequences located at the 3¿ UTR of the rat DNA polymerase beta
Ewa Grzybowska (Cancer Center Institute, Poland)
Aberrant termination triggers nonsense-mediated mRNA decay
Allan Jacobson (University of Massachusetts, USA)
Anne Willis (University of Nottingham, UK)
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Riobosome structure and factor mechanism
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