Organizers:
Lindy Holden-Dye (University of Southampton, UK)
Vincent O¿Connor (University of Southampton, UK)
F. Anne Stephenson (School of Pharmacy, London, UK)
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Molecular determinants of synaptic function: molecules and models
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Atomic structures determining synaptic function
Thursday 22 September 2005
08:00 - 09:00 Coaches leave Southampton University for Chilworth Manor
09:00 - 09:15 Welcome and introduction
Structure and gating mechanism of the nicotinic acetylcholine receptor
Nigel Unwin (MRC-LMB Cambridge, UK)
Selected oral communication
Identification of glycine receptor associated gephyrin splice variants
Selected oral communication - Ingo Paarmann ( Max Planck Institute for Brain Research, Germany)
GRIF-1/kinesin-1 interactions: a confocal microscopy study
Selected oral communication - Karine Pozo (School of Pharmacy, London, UK)
10:30 - 11:00 Coffee/tea break and poster viewing
Role of the conserved glutamine 291 in the rat gamma-aminobutyric acid transporter rGAT-1
Selected oral communication - Stefania Mari (University of Milan, Italy)
Neurochemical changes associated with prion disease using the ME7 murine scrapie model
Selected oral communication - Bryony Gray (University of Southampton, UK)
12:15 - 14:00 Lunch and formal poster session
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Functional determinants of model synapses
Thursday 22 September 2005
08:00 - 09:00 Coaches leave Southampton University for Chilworth Manor
09:00 - 09:15 Welcome and introduction
10:30 - 11:00 Coffee/tea break and poster viewing
Molecular mechanisms of synaptic target selection and presynaptic assembly in C. elegans
Kang Shen (Stanford University, USA)
12:15 - 14:00 Lunch and formal poster session
Glycine transporters: essential regulators of synaptic transmission
Heinrich Betz (MPIH, Germany)
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Glutamate receptors: models of post-synaptic function
Thursday 22 September 2005
12:15 - 14:00 Lunch and formal poster session
Genetic and proteomic studies of postsynaptic complexes
Seth Grant (University of Cambridge, UK)
15:30 - 16:00 Coffee/tea break and poster viewing
Building a synapse: genetic analysis of glutamatergic transmission
Andres Villu Maricq (University of Utah, USA)
18:15 - 19:00 Coaches leave Chilworth Manor for Southampton University
20:00 - 22:30 Meeting dinner - Kuti's Brasserie, Southampton
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Pre-synaptic determinants of synaptic function
Thursday 22 September 2005
12:15 - 14:00 Lunch and formal poster session
15:30 - 16:00 Coffee/tea break and poster viewing
The role of neuroligins in synaptogenesis and synapse function
Nils Brose (MPIEM, Germany)
Timing of protein-protein interactions required for synaptic vesicle exocytosis
George Augustine (Duke University, USA)
18:15 - 19:00 Coaches leave Chilworth Manor for Southampton University
20:00 - 22:30 Meeting dinner - Kuti's Brasserie, Southampton
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Metabolic regulation of synaptic function
08:00 - 09:00 Coaches leave Southampton University for Chilworth Manor
The molecular architecture of signal transduction complexes
John Scott (HHMI/Vollum Institute, USA)
Polyunsaturated fatty acids and neurotransmission in C. elegans
10:30 - 11:00 Coffee/tea break
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Dynamic regulation of synaptic function
08:00 - 09:00 Coaches leave Southampton University for Chilworth Manor
10:30 - 11:00 Coffee/tea break
Lipid regulation of the synaptic vesicle cycle
Kendal Broadie (Vanderbilt University, USA)
Phosphoinositide-specific control of regulated exocytosis
Giampietro Schiavo (Cancer Research UK)
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Defining determinants of integrative synaptic function
08:00 - 09:00 Coaches leave Southampton University for Chilworth Manor
10:30 - 11:00 Coffee/tea break
Oxygen sensation and the evolution of circuits networks in C. elegans
Mario de Bono (MRC-LMB Cambridge, UK)
Determinants of broad bandwidth transmission at a central synapse
Angus Silver (University College London, UK)
15:00 - 15:30 Coffee/tea break
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Molecular dysfunction in models of disease
15:00 - 15:30 Coffee/tea break
Calcium channelopathies leading to epilepsy and cerebellar ataxia
Annette Dolphin (University College London, UK)
Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
David Shepherd (University of Southampton, UK)
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