Organizers:
Jeremy Tavare (University of Bristol, UK)
Guy Rutter (University of Bristol, UK)
Andrew Halestrap (University of Bristol, UK)
Timetable
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Introduction
Thursday 22 September 2005
12:00 - 14:00 Lunch and registration
Andrew Halestrap (University of Bristol, UK)
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Part 1 - Insulin signalling and metabolic regulation
Thursday 22 September 2005
An overview of insulin signalling
Philip Cohen (University of Dundee, UK)
Mechanism of insulin action on glucose uptake
Jeremy Tavaré (University of Bristol, UK)
Insulin regulation of protein synthesis
Chris Proud (University of British Columbia, Canada)
16:15 - 16:45 Coffee/tea break
Regulation of the pyruvate dehydrogenase complex
Mulchand Patel (State University of New York at Buffalo, USA)
The regulation of acetyl-CoA carboxylase
Roger Brownsey (University of British Columbia, Canada)
Diabetes and obesity: experiments of nature
Stephen O'Rahilly (University of Cambridge, UK)
18:30 - 22:30 Drinks Reception and Meeting Dinner
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Part 2 - Calcium and the regulation of mitochondrial function
Remodelling the calcium signalsome
Mike Berridge (The Babraham Institute, UK)
Calcium waves in cell signalling
Andrew Thomas (New Jersey Medical School, USA)
Calcium, mitochondria and reperfusion injury
Andrew Halestrap (University of Bristol, UK)
10:45 - 11:15 Coffee/tea break
Calcium, mitochondria and apoptosis
Rosario Rizzuto (University of Ferrara, Italy)
Applying science to drug discovery
Jim McCormack (University of Oxford, UK)
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Part 3 - Insulin secretion: the b cell in health and disease
12:15 - 14:00 Lunch and poster session
ATP-sensitive K+ channels and insulin secretion: their role in health and disease
Frances Ashcroft (University of Oxford, UK)
The dynamics of single insulin release events in health and disease
Guy Rutter (University of Bristol, UK)
Clathrin-independent endocytosis
Ben Nichols (University of Cambridge, UK)
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