Organizers:
Barbara Mulloy (NIBSC, UK)
Chris Rider (Royal Holloway, University of London, UK)
12:00 - 13:15 Registration and lunch
Signalling by HGF/SF and MET - The role of heparan-sulphate co-receptors
Ermanno Gherardi (University of Cambridge, UK)
Interaction of the guidance molecule Slit with cellular receptors
Erhard Hohenester (Imperial College London, UK)
The relevance of glycosaminoglycan interactions for chemokine biology
Amanda Proudfoot (Serono, Switzerland)
15:00 - 15:30 Coffee/tea break
Protein-GAG interactions: new surface-based advances and nanotechnology probes
Dave Fernig (University of Liverpool, UK)
Structures of heparin binding sites on cytokines
Barbara Mulloy (NIBSC, UK)
Developing chemokine mutants with improved proteoglycan affinity and knocked-out GPCR activity as anti-inflammatory recombinant drugs
Andreas Kungl (University of Graz, Austria)
16:45 - 18:15 Poster Session and Drinks Reception (sponsored by Plasso Technology Ltd)
Multiprotein signalling complexes - regional assembly on heparan sulphate
John Gallagher (The Paterson Institute for Cancer Research, UK)
20:00 - 22:00 Meeting Dinner
The role of heparan sulphate in fibroblast growth factor signalling
Nic Harmer (University of Cambridge, UK)
TSG-6: a pluripotent inflammatory mediator?
Tony Day (University of Manchester, UK)
The role of heparan sulphate proteoglycans in angiogenesis
Sally Stringer (University of Manchester, UK)
10:15 - 10:45 Coffee/tea break
Structural determination of heparan sulfate required for PDGF-BBL interaction in pericyte recruitment
Sindhulakshmi Kurup (Uppsala University, Sweden)
Basic FGF is bound to perlecan in the pericellular matrix of articular cartilage, and acts as a mechanical transducer in loaded articular chondrocytes
Tonia Vincent (Imperial College London, UK)
Heparin/heparan sulphate binding in the TGF- b cytokine superfamily
Chris Rider (Royal Holloway, University of London, UK)
Interferon and heparan sulphate
Hugues Lortat-Jacob (IBS, France)
Specificity in heparan sulphate binding to growth factors: investigations using saccharide libraries and microarrays
Jeremy Turnbull (University of Liverpool, UK)
12:45 - 14:00 Lunch and Networking