Organizer:
Dr Dave Buttle (University of Sheffield, UK)
Timetable
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General topics
Chair:
Bruce Caterson (University of Cardiff, UK)
11:00 - 12:50 Registration
Dave Buttle (University of Sheffield, UK)
The regulation of matrix turnover: fibroblasts, forces, factors and fibrosis
Geoff Laurent (University College London, UK)
The serine protease HtrA1 regulates physiological and pathological matrix mineralization
Selected oral communication - Ann Canfield (University of Manchester, UK)
The molecular basis of inter-a-inhibitor heavy chain transfer onto hyaluronan
Selected oral communication - Anthony Day (University of Manchester, UK)
Influence of the extracellular matrix on the mechanical properties of tissue engineered cartilage
Selected oral communication - Marie Plainfosse (University of Sheffield, UK)
15:10 - 15:30 Coffee/tea break, poster viewing and trade exhibition
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Intervertebral Disc
Chair:
Tony Freemont (University of Manchester, UK)
Matrix synthesis & degradation in human intervertebral disc degeneration
Judith Hoyland (University of Manchester, UK)
The influence of nutrient supply on the growth kinetics of intervertebral disc cells
Selected oral communication - Eustace Johnson (Robert Jones & Agnes Hunt Orthopaedic Hospital, UK)
Age-related changes of cytoskeletal composition: a preliminary study of the role of cytoskeleton in intervertebral disc degeneration
Selected oral communication - Siyuan Li (Cardiff University, UK)
From collagen chemistry towards cell therapy - a personal journey
Fell-Muir Prize Lecture: Emeritus Professor Michael Grant (University of Manchester, UK)
18:40 - 19:30 Drinks reception and poster session
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Turnover in the CNS
Chair:
Nicola Woodroofe (Sheffield Hallam University, UK)
Brain matrix: structure, turnover and necessity
Uwe Rauch (Lund University, Sweden)
Astrocyte-leucocyte interactions and the mechanisms regulating matrix degradation in CNS tuberculosis
Selected oral communication - Jon Friedland (Imperial College London, UK)
Bovine brain matrix metalloproteinases; detection and inhibition
Selected oral communication - Elena Ganea (Romanian Academy, Romania)
Changes in brain expression of Chondroitin Sulphate Proteoglycans (CSPGs) following transient middle cerebral artery occlusion in the rat
Selected oral communication - Gail Haddock (Sheffield Hallam University, UK)
11:10 - 11:40 Coffee/tea break, poster viewing and trade exhibition
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Fibroses
Chair:
Cay Kielty (University of Manchester, UK)
TGFb and Smad3 link Matrix expression and progressive fibrosis
Jack Gauldie (McMaster University, Canada)
Fibrillin-1 regulates the bioavailability of TGFa
Selected oral communication - Shazia Chaudhry (University of Manchester, UK)
Biochemical evaluation of hepatocellular dysfunction and extracellular matrix alteration in mice infected with Schistosoma mansoni
Selected oral communication - Folashade Kassim (Lagos State University, Nigeria)
Tenascin-C regulates fibroblast migration within 3D fibrin-fibronectin matrices
Selected oral communication - Kim Midwood (Imperial College London, UK)
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Tumor/Stroma interactions
Chair:
Colby Eaton (University of Sheffield, UK)
3D extracellular matrix culture models of EGFR signalling and drug response
Paraic Kenny (Lawrence Berkeley National Lab, USA)
Bone marrow stromal cell-derived insulin-like growth factor (IGF) II enhances growth and survival of prostate cancer cells and potentiates androgen action.
Selected oral communication - Neil Cross (University of Sheffield, UK)
Exploring New Roles for Cathepsin K in Prostate Cancer
Selected oral communication - Izabela Podgorski (Wayne State University School of Medicine, USA)
Phagocytosis of collagen by fibroblasts and invading cancer cells is mediated by MT1-MMP
Selected oral communication - Jaro Sodek (University of Toronto, Canada)
16:50 - 17:00 Announcement of poster prizes
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