Organizers:
Clare Bryant (University of Cambridge, UK)
Peter Morley (GlaxoSmithKline, UK)
Nick Gay (University of Cambridge, UK)
Luke O¿Neill (Trinity College Dublin, Ireland)
Kate Fitzgerald (University of Massachusetts, USA)
Timetable
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Welcome and Introduction
12:30 - 14:00 Registration
14:00 - 14:10 Introduction
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Session one: Sepsis
Regulation of interactions of endotoxin with mammalian cells
Jerrold Weiss (University of Iowa, USA)
PAR2 and TLR4 signal transduction: A novel paradigm for receptor cooperativity
Stefanie Vogel (University of Maryland School of Medicine, USA)
Pattern recognition and subcellular trafficking of human TLR1: A tale of two SNPs
Richard Tapping (University of Illinois, USA)
16:20 - 16:40 Coffee/tea break
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Session two: Cardiovascular disease
Role of pattern recognition receptors in cardiovascular disease
Jane Mitchell (Imperial College London, UK)
Toll-like receptors in atherosclerosis
Linda Curtiss (The Scripps Research Institute, USA)
17:45 - 19:30 Poster session 1 and drinks reception
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Session three: Cancer
HPV from infection to cancer
Margaret Stanley (University of Cambridge, UK )
The innate adaptive connection: TLRs and beyond
Kasper Hoebe (The Scripps Research Institute, USA)
Activation of NF-kB: A novel approach to vaccination
Selected oral communication - Jeremy Wales (Imperial College London, UK)
Conserved and distinct features of the avian TLR system and implications for control of bird-borne zoonoses
Selected oral communication - Amy Boyd (Institute for Animal Health, UK)
10:25 - 10:50 Coffee/tea break
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Session four: Viral disease
Synthetic Agonists of TLR7, 8, and 9
Sudhir Agrawal (Idera Pharmaceuticals, USA)
RNA modification influencing recognition by Toll-like receptors
Stefan Bauer (Philipps University Marburg, Germany)
Pharmacology of endosomal TLR agonists in viral disease
Devron Averett (Anadys Pharmaceuticals, Inc, USA)
Structure-function analysis of caspase-1/CARD-mediated NF-kB activation
Selected oral communication - Kristof Kersse (Ghent University, Belgium)
The vaccinia virus protein K7 modulates innate immune signalling pathways
Selected oral communication - Martina Schroeder (Trinity College Dublin, Ireland)
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Session five: Parasites
How Toll receptors become activated by their ligand
Douglas Golenbock (University of Massachusetts, USA)
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Session six: Gastrointestinal disease
TLR signalling in the intestine in health and disease
Maria Abreu (Mount Sinai School of Medicine, USA)
Roles of Nod1 and Nod2 in immunity to bacterial infections
Stephen Girardin (University of Toronto, Canada)
15:45 - 16:05 Coffee/tea break
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Session seven: Autoimmunity
TLR9 dependent DNA immune complex mediated cell activation by High Mobility Group Box Protein 1 (HMGB1) and the Receptor for Advanced Glycation End products (RAGE)
Anthony Coyle (Medimmune Inc, USA)
Pattern recognition receptors in autoimmune diseases
Andrew Luster (Massachusetts General Hospital/Harvard Medical School, USA)
Inhibition of TLR signalling
Christopher Karp (University of Cincinnati, USA)
17:55 - 19:30 Poster Session 2
19:30 - 21:30 Gala Dinner
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Session eight: Rheumatoid arthritis
Do TLRs contribute to driving inflammation in RA?
Brian Foxwell (Kennedy Institute of Rheumatology, UK)
Distinct functional expression of the TLR system in human newborns: Basic mechanisms and translational opportunities.
Ofer Levy (Harvard Medical School, USA)
Structural and functional characterisation of Toll-like receptor pathway single nucleotide polymorphisms
Selected oral communication - Alexander Weber (Deutsches Krebsforschungszentrum, Germany)
Novel insights in LPS signaling: the opsonic role of MD-2
Alberto Visintin (University of Massachusetts, USA)
10:40 - 11:00 Coffee/tea break
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Session nine: Respiratory diseases
TLR-regulated inflammatory networks underpin respiratory disease
Ian Sabroe (University of Sheffield, UK)
Fernando Bazan (Genentech Inc, USA)
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Conclusion
Drosophila - A powerful model system for innate immunity
Neal Silverman (University of Massachusetts, USA)
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