Organizer:
Heather Wallace (University of Aberdeen, UK)
Timetable
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Update on polyamine metabolism
10:00 - 12:00 Registration
Welcome from the University of Aberdeen and domestic arrangements
Heather Wallace (University of Aberdeen, UK)
Polyamine synthesis in normal and neoplastic growth
Anthony E. Pegg (Pennsylvania State University, USA)
Polyamine catabolism: the good, the bad, and the ugly
Robert A. Casero (The Johns Hopkins School of Medicine, USA)
Metabolic enzymes regulated by the MYC oncogene are possible targets for chemotherapy or chemoprevention
Jonas Nilsson (Umeå University, Sweden)
Antizyme inhibitor, a defective ornithine decarboxylase, or a physiological regulator of polyamine biosynthesis and cellular proliferation
Chaim Kahana (Weizmann Institute of Science, Israel)
15:15 - 15:50 Coffee/tea break
ODC and AdoMetDC in trypanosomatids
Lo Persson (Lund University, Sweden)
Unusual aspects of the polyamine transport system affect the design of strategies for use of polyamine analogues in chemoterapy
John Mitchell (Northern Illinois University, USA)
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Biogenic amines and disease
Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models
Eugene Gerner (Arizona Cancer Centre, USA)
Mechanisms of polyamine catabolism-induced acute pancreatitis
Leena Alhonen (University of Kuopio, Finland)
19:00 - 20:30 Civic reception
Polyamine metabolism and DNA methylation in childhood leukaemia
Raymond Schipper (University Medical Centre Nijmegen, The Netherlands)
Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse
Frank Berger (University of South Carolina, USA)
Reducing the availability of polyamines for a developing tumour
Ian Pryme (University of Bergen, Norway)
Survival and stress-activated signal transduction pathways leading to cell death: MDL 72527 and spermine oxidation products induce alterations on tumor cells
Enzo Agostinelli (University of Rome, Italy)
10:50 - 11:20 Coffee/tea break
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Biogenic amines in food
Contributions of working group 1 ¿Amines and Food safety¿ ¿ A Review
Friederich Bauer (Institute of Meat Technology and Hygiene, Austria)
Occurrence of nitrates, nitrites and nitrosamines in foodstuffs in Cyprus and estimation of population exposure to nitrates
Eleni Ioannou-Kakouri (State General Laboratory Ministry of Health, Cyprus)
Biogenic amine content of Hungarian food and beverages
Livia Simon Sarkadi (Budapest University of Technology and Economics, Hungary)
Biogenic amines formation in Lithuanian meat products
Alvija Salaseviciene (Kaunas College, Lithuania)
Histamine in food - is there anything to worry about?
Agnieszka Fogel (Medical University of Lodz, Poland)
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Chemotherapy and chemoprevention
Chemopreventive efficacy of aspirin-difluoromethylornithine combination by computed tomographic (CT) colonography
Francis Raul (Institut de Recherche Contre les Cancers de l¿Appareil Digestif, France)
Polyamine-based analogues as biochemical probes and potential therapeutics
Patrick M. Woster (Wayne State University, USA)
15:25 - 15:55 Coffee/tea break
Polyamine signalling and cancer chemoprevention
Heather Wallace (University of Aberdeen, UK)
Novel approach to design isosteric charge-deficient analogue of spermine and its biochemical important derivatives
Alex Khomutov (Engelhardt Institute of Molecular Biology, Russia)
Spectroscopic studies on biogenic polyamines
Maria Marques (University of Coimbra, Portugal)
19:00 - 20:00 Pre-dinner drinks
20:00 - 23:00 Meeting dinner
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Biogenic amine metabolism
Development of post-genomics tools for characterization of amine metabolic crosstalk in human cells
Francisca Sánchez Jiménez (University of Malaga, Spain)
Nuclear and membrane receptors-mediated signalling pathways in modulation of polyamine biosynthesis and interconversion
Barbara Grzelakowska-Sztabert (Polish Academy of Sciences, Poland)
Conversion of cancer stem cells into normal progeny by polyamine depletion
Olle Heby (Umeå University, Sweden)
Potassium channel blockers quinidine and CsCl2 halt cell proliferation in C6 glioma cells via a polyamine dependent mechanism
Thomas Weiger (University of Salzburg, Austria)
10:40 - 11:10 Coffee/tea break
Catabolic oxidation of g-glutamyl-polyamines: a potential pathway for a selective modulation of protein crosslink intracellular levels
Simone Beninati (Tor Vergata University, Italy)
Inhibition of mitochondrial agmatine transport by guanidine compounds
Maria Angelica Grillo (University of Torino, Italy)
Inhibition of cell proliferation and induction of apoptosis by polyamine depletion
Stina Oredsson (University of Lund, Sweden)
Influenced of polyamine depletion on NSAID-induced cytotoxicity in colorectal cancer cells
Selected oral communication - Fiona Saunders (University of Aberdeen, UK)
Monoamine oxidase A and amine metabolism
Selected oral communication - Rona Ramsay (University of St Andrews, UK)
14:15 - 15:15 Poster session with tea/coffee
15:15 - 17:00 MC Meeting (COST participants only)
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