Organizers:
Brian Austen (St George's University of London, UK)
Robin Leatherbarrow (Imperial College London, UK)
Christopher Southan (AstraZeneca, UK)
Timetable
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Session One
13:30 - 15:00 Registration
Rhomboid proteases, their biological functions and therapeutic possibilities
Matthew Freeman (Medical Research Council, UK)
An alternative strategy for inhibiting multidrug-resistant mutants of the dimeric HIV-1 protease by targeting the subunit interface
Selected oral communication - Ludovic Bannwarth (CNRS-Université, Paris)
Assay considerations for proteolytic cascades: the quest for Xase exosite inhibitors
Augustin Amour (GlaxoSmithKline, UK)
Investigation of a novel serine protease involved in cell survival
Selected oral communication - Kelly Moffitt (Queens University Belfast, UK)
New opportunities for protease ligand binding site comparisons using SitesBase
Richard Jackson (University of Leeds, UK)
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Session Two
Characterization of protease inhibitors using peptidomics and correlation associated networks
Petra Budde (Biovision Discovery, Germany)
BACE1 cytoplasmic domain interacrts with the copper chaperone for superoxide dismutase-1 and binds copper
Colin Dingwall (GlaxoSmithKline, UK)
Analysis of beta-secretase kinetics and the protein levels of BACE1 and BACE2 in human control and Alzheimer¿s disease brain
Selected oral communication - John Stockley (University College Cork, Ireland)
11:15 - 11:45 Coffee/tea break
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Session Three
Inhibition of the lipidation of ß-secretase - a potential therapy for Alzheimer's disease
Richard Parsons (St George's University of London, UK)
TTR proteolytic activity enhances apoA-I fibril formation
Selected oral communication - Marcia Liz (Universidade do Porto, Portugal)
The NEP and ACE families as paradigms for elucidating protease biology
Antony Turner (University of Leeds, UK)
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Session Four
Roles and regulation of membrane-associated serine proteases
Vincent Ellis (University of East Anglia, UK)
Neuropeptidomics: strategies for reliable and sensitive identification of endogenous peptides
Per Andren (University of Uppsala, Sweden)
New advances, and novel applications for MALDI-TOF imaging
Selected oral communication - Laura Main (BrukerDaltonics Ltd, Coventry)
16:15 - 18:00 Poster session
19:00 - 21:00 Wine and banquet dinner
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Session Five
Proteomic discovery of metalloproteinase substrates in the cellular context by isotope tag labelling reveals diverse substrate degradomes
Richard Dean and Chris Overall (University of British Columbia, Vancouver, Canada)
Functional imaging of protease activity in health and disease
Matthew Bogyo (Stanford University, USA)
11:00 - 11:30 Coffee/tea break
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Session Six
Structural analysis of foot-and mouth 3C virus, a viable target for antiviral drugs
Stephen Curry (Imperial College London, UK)
Exploiting new genome data and web resources for the phylogenetic analyisis of proteases, substrates and inhibitors
Christopher Southan (AstraZeneca, Sweden)
13:00 - 13:15 Closing remarks
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