Organizer:
David Garrod (University of Manchester, UK)
16:00 - 18:00 Registration
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Adhesive cell-cell interactions and intercellular junctions ¿ Part 1
Chair:
David Garrod (University of Manchester, UK)
08:00 - 09:00 Registration
Cadherin structure and specificity
Lawrence Shapiro (Columbia University, USA)
Biochemical and structural analysis of alpha-catenin in cell-cell contacts
William Weis (Stanford University School of Medicine, USA)
Cytomechanics of cell-cell adhesion
W. James Nelson (Stanford University, USA)
10:30 - 11:00 Coffee/tea break
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Structural aspects of cell adhesion signalling
Chairs:
Mark Ginsberg (University of California San Diego, USA)
Martin Humphries (University of Manchester, UK)
Structural insight into Slit-Robo signalling
Erhard Hohenester (Imperial College London, UK)
Protein tyrosine phosphatases in cell-cell adhesion
Nicholas Tonks (Cold Spring Harbor Laboratory, USA)
A tension dependent link between E-cadherin and actin, which involves Vinculin and associated proteins
Selected oral communication - Johan de Rooij (The Netherlands Cancer Institute, Amsterdam, The Netherlands)
Opening up a can of worms: genetic analysis of alpha-catenin function
Selected oral communication - Neale Harrison (University of Aberdeen, UK)
The effects of heterogeneity on the binding of the Notch intracellular domain to the transcription factor CSL: a case of biologically tuned disorder
Doug Barrick (Johns Hopkins University, USA)
Receptor protein tyrosine phosphatase m ¿ measuring where to stick
Yvonne Jones (University of Oxford, UK)
The cellular prion protein PrPc is involved in the proliferation of epithelial cells and in the distribution of junction-associated proteins
Selected oral communication - Caroline Clair (Centre de Recherche des Cordeliers, Paris, France)
Molecular force spectroscopy of homophilic nectin-1 interactions
Selected oral communication - Tong Seng Lim (Bioinformatics Institute, Singapore )
15:00 - 15:30 Coffee/tea break
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Adhesive cell-cell interactions and intercellular junctions ¿ Part 2
Chairs:
Beat Imhof (Université de Genève, Switzerland)
Cay Kielty (University of Manchester, UK)
Electron tomography of desmosomes
David Stokes (New York University, USA)
Cryo- electron tomography of vitreous sections of native epidermal desmosomes
Ashraf Al-Amoudi (EMBL Heidelberg, Germany)
Structure of artificial VE-cadherin junction
Olivier Lambert (University of Bordeaux, France)
Hyper-adhesion; a new concept in cell-cell adhesion
David Garrod (University of Manchester, UK)
17:30 - 19:00 Drinks reception and poster viewing
The role of JAM-C in leukocyte migration and angiogenesis
Beat Imhof (Université de Genève, Switzerland)
Beyond structure: molecular mechanism of intercellular adhesion
Deborah Leckband (University of Illinois, USA)
Post-adhesive events in malaria cytoadherence
Alister Craig (University of Liverpool, UK)
10:30 - 11:00 Coffee/tea break
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Integrins and focal adhesions ¿ structure, function and regulation
Chairs:
W. James Nelson (Stanford University, USA)
Karl Kadler (University of Manchester, UK)
Conformational change and ligand binding in integrins
Tim Springer (Harvard University, USA)
Integrin activation: a roadmap
Mark Ginsberg (University of California San Diego, USA)
How do cells decide which way to turn?
Martin Humphries (University of Manchester, UK)
Interplay between integrin subunits in signalling
Selected oral communication - Johanna Jokinen (University of Turku, Finland)
A role for syntenin in syndecan 1 mediated formation of filopodia
Selected oral communication - Béatrice Sulka (Institut de Biologie et Chimie des Protéines, Lyon, France)
14:00 - 15:45 Poster session with coffee / tea
Microfluidic SP1.0 Platform - bringing in vitro close to in vivo
Exhibitor presentation - Kate Fitzgerald (Stratech Scientific Ltd, UK)
Regulation and activation of cell migration molecules
Robert Liddington (The Burnham Institute for Medical Research, USA)
Integrin connections to the cytoskeleton
Jonas Emsley (University of Nottingham, UK)
Targeted deletion of tgm-2 uncovers a role for extracellular transglutaminase-2 in RhoA downregulation during fibroblast adhesion to fibronectin
Selected oral communication - Elisabetta Verderio (Nottingham Trent University, UK)
The structure of the C-terminal actin-binding domain of talin
Selected oral communication - Alexandre Gingras (University of Leicester, UK)
19:00 - 19:40 Tour of Old Trafford Football Stadium (coaches depart 18:30)
19:45 - 23:00 Conference dinner (coaches depart 19:15)
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Structure and assembly of extracellular matrix
Chairs:
Jonas Emsley (University of Nottingham, UK)
Tim Springer (Harvard University, USA)
Wednesday 5 December 2007
Cell-collagen interactions
Richard Farndale (University of Cambridge, UK)
Dependence of collagen triple helical conformation on amino acid sequence: a new approach
Jordi Bella (University of Manchester, UK)
Fibrillin microfibril assembly: essential roles for alpha5beta1 integrin and fibronectin
Cay Kielty (University of Manchester, UK)
10:30 - 11:00 Coffee/tea break
Fibrillin-integrin interactions in health and disease
Penny Handford (University of Oxford, UK)
Cell-mediated organisation of collagen fibrils
Karl Kadler (University of Manchester, UK)
Studies of focal adhesion assembly
Iain Campbell (University of Oxford, UK)
12:30 - 13:00 General discussion
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