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Transition metals in biochemistry - A joint meeting with the Inorganic Biochemistry Discussion Group to honour Professor Andrew Thomson FRS

24—26 June 2008

University of East Anglia, UK



Organizers:
David Richardson (University of East Anglia, UK)
Nick Watmough (University of East Anglia, UK)
Steve Chapman (University of Edinburgh, UK)
Sponsors:

Session One

Chair:
David Richardson (University of East Anglia, UK)
Tuesday 24 June 2008
12:30 - 14:00 Registration

14:00 - 14:10
Introduction
14:10 - 14:40
Engineering function in synthetic protein maquettes
Les Dutton (University of Pennsylvania, Philadelphia, USA)
14:40 - 15:10
Iron-sulphur cluster biosynthesis
Michael Johnson (University of Georgia, Athens, USA)
15:10 - 15:40
A tale of two dioxygenases
Steve Chapman (University of Edinburgh, UK)
15:40 - 17:00 Poster session 1 (odd numbered posters) with tea/coffee

17:00 - 17:30
Role of transition metals in oxygen sensing by humans
Chris Schofield (University of Oxford, UK)
18:00 - 19:00 Dinner

Session Two

Chairs:
Peter Rich (University College London, UK)
Steve Chapman (University of Edinburgh, UK)
Wednesday 25 June 2008
09:10 - 09:40
The complexities of c-type cytochrome biogenesis
Stuart Ferguson (University of Oxford, UK)
09:40 - 10:10
Structures and reaction pathways of the molybdenum centres of sulfite oxidizing enzymes by pulsed EPR spectroscopy
John Enemark (The University of Arizona, Tucson, USA)
10:10 - 10:40
Copper and biological methane oxidation
Amy Rosenzweig (Northwestern University, Evanston, USA)
10:40 - 11:10 Coffee/tea break

11:10 - 11:25
Tuning the heme redox potential in the cytochrome c6 family
Selected oral communication - Jonathan Worrall (University of Essex, UK)
11:25 - 11:40
The 3-His iron center ¿ a distinct motif of catalytic function in non-heme metal dependent emzymes
Selected oral communication - Stefan Leitgeb (Graz University of Technology, Austria)
11:40 - 12:10
Iron acquisition by the heme-binding Isd proteins in Staphylococcus aureus - studies of the mechanism using magnetic circular dichroism spectroscopy and mass spectrometry
Martin Stillman (The University of Western Ontario, Canada)
12:10 - 12:40
Signal perception by FNR: the role of the iron sulfur cluster
Jason Crack (University of East Anglia, UK)
12:40 - 14:00 Lunch and poster session 2 (all posters)

14:00 - 17:40 Boat trip on the river Wensum in Norwich

17:45 - 18:45
Bioinorganic chemistry in the UK: the role of the Centre for Metalloprotein Spectroscopy and Biology at UEA
The IBDG Lecture - Mike Wilson (University of Essex, UK)
19:00 - 21:00 Drinks reception and meeting dinner

Session Three

Chair:
Les Dutton (University of Pennsylvania, Philadelphia, USA)
Thursday 26 June 2008
09:10 - 09:40
Bacterial nitric oxide synthases: structure, reactivity and function
Brian Crane (Cornell University, Ithaca, USA)
09:40 - 10:10
New insights into the activity of Pseudomonas aeruginosa cd1 nitrite reductase
Francesca Cutruzzolà (University of Rome 'La Sapienza', Italy)
10:10 - 10:40
Metallo-regulatory proteins and nitric oxide signalling in bacteria
Stephen Spiro (University of Texas, Dallas, USA)
10:40 - 11:10 Coffee/tea break

11:10 - 11:25
Coherent Raman detected electron spin resonance spectroscopy: a ¿double resonance¿ technique linking electron spin resonance and magnetic circular dichroism
Selected oral communication - Stephen Bingham (University of Bath, UK)
11:25 - 11:40
Spectroscopic studies of the alternative oxidase
Selected oral communication - Anthony Moore (University of Sussex, UK)
11:40 - 12:10
Spectroscopy of bacterial nitric oxide reductase
Myles Cheesman (University of East Anglia, UK)
12:10 - 12:40
The iron-sulphur clusters in mitochondrial complex I
Judy Hirst (Medical Research Council, Cambridge, UK)
12:40 - 14:00 Lunch and poster session 3 (even numbered posters)

Session Four

Chair:
Nick Watmough (University of East Anglia, UK)
Thursday 26 June 2008
14:10 - 14:40
Mid-infrared studies of ligand binding to cytochrome oxidase
Peter Rich (University College London, UK)
14:40 - 15:10
Oxygen-reduction coupled to proton pumping in respiratory oxidases
Peter Brzezinski (Stockholm University, Sweden)