Organizers:
John Howl (University of Wolverhampton, UK)
Sarah Jones (University of Wolverhampton, UK)
Brian Austen (St George's, University of London, UK)
Bernard Lebleu (Montpellier University, France)
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Cell penetrating peptides
Applications of cell-penetrating peptides in regulation of gene expression
Ulo Langel (Stockholm University, Sweden)
Cell penetrating peptide-based delivery of oligonucleotides: an overview
Bernard Lebleu (Montpellier University, France)
Tumor-homing peptides: tools for targeting, imaging and destruction
Pirjo Laakkonen (University of Helsinki, Finland)
19:00 - 20:00 Welcome drinks reception sponsored by CEM, and dinner
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Mechanisms of cell penetrating peptide-mediated cellular transduction
Chair:
Brian Austen (St George's, University of London, UK)
Arginine-rich peptides and their internalization mechanisms
Shiroh Futaki (Kyoto University, Japan)
On the prospects of cell penetrating peptides for epithelial drug delivery
Hans Merkle (ETH Zurich, Switzerland)
Understanding histidine rich amphipathic peptide mediated gene delivery using solid-state NMR techniques
Selected Oral Communication - James Mason (Louis Pasteur University, France)
10:40 - 11:10 Coffee/tea break
Cell surface markers as molecular portals for peptide and oglionucleotide entry into cells
Jean Gariepy (Ontario Cancer Institute, Canada)
A comprehensive model for the uptake of cationic cell-penetrating peptides
Roland Brock (University of Tubingen, Germany)
12:30 - 14:00 Lunch (and Poster Session)
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Functionality and dynamics of cell penetrating peptides
Chair:
Bernard Lebleu (Montpellier University, France)
12:30 - 14:00 Lunch (and Poster Session)
Proline-rich cell-penetrating peptides: protease degradation resistance
Ernest Giralt (Parc Cientific de Barcelona, Spain)
Bax inhibiting peptide and cell penetrating penta-peptide
Shigemi Matsuyama (Case Western Reserve University, USA)
(R-Ahx-R)4 Cell penetrating peptide enhances the delivery of antisense morpholino oligomers
Selected Oral Communication - Hong Moulton (AVI BioPharma, Inc, USA)
15:40 - 16:10 Coffee/tea break
Peptide conjugates of PNA as steric block modulators of gene expression
Mike Gait (University of Cambridge, UK)
Tumor imaging with cell penetrating peptides activated by matrix metalloproteinases
Roger Tsien (University of California, San Diego, USA)
18:30 - 23:00 Dinner - delegates asked to make their own arrangements
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Utility of CPP-conjugates for gene modulation and therapeutic application
Chair:
Sarah Jones (University of Wolverhampton, UK)
TAT-mediated delivery of siRNAs therapeutics
Bryan Meade (University of Califonia at San Diego, USA)
Peptide therapeutic targeting of transcriptional repressors in B-cell lymphomas
Ari Melnick (Albert Einstein College of Medicine, USA)
Synthesis and application and quantitation of clamb-bioshuttle-carriers for plasmid delivery into prostate cancer cells
Selected Oral Communication - Ruediger Pipkorn (German Cancer Research Center, Germany)
10:40 - 11:10 Coffee/tea break
CPP mediated lung siRNA delivery
Mark Lindsay (Imperial College London, UK)
Peptide-based nanoparticles for in vivo delivery of therapeutic siRNA
Gilles Divita (National Center for Scientific Research, France)
12:30 - 14:00 Lunch (and Poster Session)
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Physiological relevance and clinical development of CPPs and nanoparticulate systems
Chair:
John Howl (University of Wolverhampton, UK)
12:30 - 14:00 Lunch (and Poster Session)
Protein transduction: characterization, optimization and therapeutic applications
Paul Robbins (University of Pittsburgh, USA)
TATp-mediated intracellular delivery of pharmaceutical nanocarriers
Vladimir Torchilin (Northeastern University, USA)
Targeting the MHC class-II presentation pathway in allergy vaccine development
Selected Oral Communication - Claudio Rhyner (Swiss Institute of Allergy and Research, Switzerland)
15:40 - 16:10 Coffee/tea break
Cell penetrating peptides in development
Steve Harrison (KAI Pharmaceuticals, USA)
To be confirmed (Ecole Normale Superieur, France)
20:00 - 23:00 Gala Dinner
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