Organizers:
Andy Sharrocks (University of Manchester, UK)
Ron Hay (University of Dundee, UK)
Timetable
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The SUMO pathway machinery
Chair:
Hugues de The (University of Paris, France)
15:00 - 17:00 Registration
17:00 - 17:10 Opening address by Andy Sharrocks
Role of SUMO modification in the control of gene expression
Ron Hay (University of Dundee, UK)
Regulation of E2 function by SUMO
Titia Sixma (Netherlands Cancer Institute, The Netherlands)
SUMO-1, SUMO-2 and SUMO-3 polymerize in vivo via the internal sumoylation sites of SUMO-2 and SUMO-3
Selected oral communication - Alfred Vertegaal (Leiden University Medical Center, The Netherlands)
18:30 - 20:30 Welcome reception with buffet
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In vivo roles of SUMO
Chair:
Titia Sixma (Netherlands Cancer Institute, The Netherlands)
Role of SUMO modification in cellular senescence and telomere maintenance
Anne Dejean (Pasteur Institute, France)
SUMO Modification of Httex1p in HD pathogenesis
Selected oral communication - Jacqueline Gire (UC Irvine, USA)
Sumoylation dependent function of a T-box transcriptional repressor in C. elegans
Selected oral communication - Peter Okkema (University of Illinois, Chicago, USA)
Role of sumolation in APL pathogenesis and therapy response
Hugues de The (University of Paris, France)
10:40 - 11:10 Coffee/tea break
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SUMO and nuclear functions (1)
Chair:
Hsiu-Ming Shih (Academia Sinica, Taiwan)
The role of SUMO ligases in genome tability in S. pombe
Felicity Watts (University of Sussex, UK)
Control of DNA replication and damage bypass by SUMO and ubiquitin
Helle Ulrich (Cancer Research UK, UK)
Dissecting the SUMOylation pathway in DT40
Selected oral communication - Kevin Hiom (MRC Laboratory of Molecular Biology, UK)
Regulation of epigenetic gene silencing by SUMO and PIAS proteins
Irina Stancheva (University of Edinburgh, UK)
13:00 - 15:30 Lunch and poster session
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SUMO and nuclear functions (2)
Chair:
Jorma Palvimo (University of Kuopio, The Netherlands)
Regulation of the dual function transcription factor Sp3 by SUMO modification
Grace Gill (Tufts University School of Medicine, USA)
Sumoylation of the RNA helicase p68 and its role in transcriptional regulation
Selected oral communication - Frances Fuller-Pace (University of Dundee, UK)
Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization
Hsiu Ming Shih (Academia Sinica, Taiwan)
Regulation of MOT1 by SUMO modification and SLX5/SLX8 in Saccharomyces cerevisiae
Selected oral communication - Greg Prelich (Albert Einstein College of Medicine, USA)
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Specificity and regulation of Sumoylation (1)
Organizer:
Susanna Chiocca (European Institute of Oncology, Italy)
Pc2 regulates sumoylation and Akt-dependent phosphorylation of CtBP
David Wotton (University of Virginia, USA)
Regulation of transcription factors by PIAS proteins
Jorma Palvimo (University of Kuopio, Finland)
Specificity and regulation of sumoylation in gene transcription
Lea Sistonen (Turku Centre for Biotechnology, Finland)
10:30 - 11:00 Coffee/tea break
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Specificity and regulation of Sumoylation (2)
Chair:
Grace Gill (Tufts University School of Medicine, USA)
Dynamic interactions between the SUMO pathway and other post-translational modifications
Andy Sharrocks (University of Manchester, UK)
Identification of constitutive and induced SUMOylation and analysis of its function using the Ubc9 fusion-directed SUMOylation (UFDS) system
Selected oral communication - Rainer Niedenthal (Hannover Medical School, Germany)
Sumoylation of papillomavirus E2 proteins
Selected oral communication - Van Wilson (Texas A&M University, USA)
Viral control of the SUMO pathway
Susanna Chiocca (European Institute of Oncology, Italy)
12:40 - 13:00 Closing remarks by Ron Hay
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