Organizers:
Philip Newsholme (University College Dublin, Ireland)
Mark Holness (Barts and the London School of Medicine and Dentistry, UK)
Tony Corfield (University of Bristol, UK)
Timetable
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Insulin secretion
Chair:
Philip Newsholme (University College Dublin, Ireland)
09:00 - 10:30 Registration
b-cell lipases and insulin secretion
Hindrik Mulder (University of Lund, Sweden)
Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance
Mary Sugden (Barts and the London School of Medicine and Dentistry, UK)
Glucolipotoxicity of the pancreatic b-cell: myth or reality?
Vincent Poitout (University of Montreal, Canada)
Arachidonic acid induces changes in gene expression and insulin secretion in the BRIN BD11 clonal rat pancreatic beta-cell line
Selected oral communication - Deirdre Keane (University College Dublin, Ireland)
13:00 - 14:30 Lunch and poster viewing
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Beta cell apoptosis
Chair:
Mark Holness (Barts and the London School of Medicine and Dentistry, UK)
Metabolic stress and islet inflammation: physiology, pathology and therapy
Marc Donath (University Hospital Zurich, Switzerland)
The cytoprotective actions of mono-unsaturated fatty acids in the pancreatic b-cell
Noel Morgan (Peninsula Medical School, UK)
The role of endoplasmic reticulum stress in lipotoxicity
Miriam Cnop (Free University of Brussels, Belgium)
Differential regulation of the ER stress response in pancreatic beta-cells exposed to long chain saturated and mono-unsaturated fatty acids
Selected oral communication - Eleftheria Diakogiannaki (Peninsula Medical School, UK)
17:00 - 18:30 Drinks reception and Poster Session 1 (odd numbers)
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Signalling in glucolipotoxicity
Chair:
Derek Brazil (University College Dublin, Ireland)
PKCepsilon is a potential target for the treatment of b-cell secretory dysfunction
Trevor Biden (Garvan Institute of Medical Research, Australia)
The NOX family of ROS generating NADPH oxidases: from physiology to toxicity
Karl-Heinz Krause (University of Geneva, Switzerland)
High glucose activates Hypoxia Inducible Factor 1 alpha (HIF1alpha) and HIF2alpha in cultured rat beta-cells
Selected oral communication - Mohammed Bensellam (University of Louvain, Belgium)
10:45 - 11:20 Coffee/tea break
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Mitochondrial dysfunction and aspects of dysregulated metabolism 1
Chair:
Neville McClenaghan (University of Ulster, Ireland)
Beta-cell sensitivity to mitochondrial injuries
Pierre Maechler (University of Geneva, Switzerland)
Adipose tissue expandability and lipotoxicity
Antonio Vidal-Puig (University of Cambridge, UK)
Regulation and consequences of differential gene expression in diabetic kidney disease
Catherine Godson (University College Dublin, Ireland)
13:35 - 15:00 Lunch and Poster Session 2 (even numbers)
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Mitochondrial dysfunction and aspects of dysregulated metabolism 2
Chair:
Tony Corfield (University of Bristol, UK)
Dynamic interplay between GlcNAcylation & phosphorylation: roles in nutrient toxicity & signaling
Gerry Hart (John Hopkins University School of Medicine, USA)
Molecular mechanisms of proteinuria in diabetes
Luigi Gnudi (Kings College London, UK)
Pharmacological approaches to regulation of insulin secretion and glucolipotoxicity with emphasis on GPR40
Dave Smith (AstraZeneca, UK)
Lack of TXNIP Protects Beta Cells Against Glucotoxicity
Selected oral communication - Anath Shalev (University of Wisconsin-Madison, USA)
17:30 - 17:45 Closing remarks
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