Organizers:
Robert White (University of Glasgow, UK)
Stefan Roberts (University of Manchester, UK)
Steve Busby (University of Birmingham, UK)
Graham Pavitt (University of Manchester, UK)
Malcolm White (University of St Andrews, UK)
Marshall Stark (University of Glasgow, UK)
Nicola Gray (MRC Human Genetics Unit, UK)
Simon Morley (University of Sussex, UK)
Special Events
Chair:
Steve Busby (University of Birmingham)
The Heatley Medal Lecture: What we have learned from high resolution structures of the ribosome
Venki Ramakrishnan (MRC LMB, Cambridge, UK)
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Medal Lecture
The Heatley Medal Lecture
The Heatley Medal Lecture: What we have learned from high resolution structures of the ribosome
Venki Ramakrishnan (MRC LMB, Cambridge, UK)
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Plenary Lectures
Chair:
Simon Morley (University of Sussex, UK)
12:00 - 13:30 Registration
The emerging role of Mass Spectrometry in structure elucidation of nucleic acid protein complexes
Carol Robinson (University of Cambridge, UK)
The mechanism of oskar mRNA localisation
Daniel St Johnston (University of Cambridge, UK)
Translational control in cancer and innate immunity
Nahum Sonenberg (McGill University, Canada)
15:30 - 16:00 Coffee / tea break
16:00 - 18:15 'Transcription' and 'Post-transcription' sessions take place
18:15 - 19:15 Drinks reception
18:15 - 19:15 Drinks reception
Chair:
Steve Busby (University of Birmingham)
The Heatley Medal Lecture: What we have learned from high resolution structures of the ribosome
Venki Ramakrishnan (MRC LMB, Cambridge, UK)
Chair:
Steve Busby (University of Birmingham, UK)
A model for all genomes: gene activation and repression
Peter Cook (University of Oxford, UK)
The Novartis Medal Lecture 2007: MeCP2 and Rett Syndrome
Adrian Bird (University of Edinburgh, UK)
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Transcription 1
Chair:
Neil Perkins (University of Dundee, UK)
Control of RNA polymerase III transcription by tumour suppressors and oncogene products
Robert White (University of Glasgow, UK)
Elevated tRNA synthesis can drive proliferation and oncogenic transformation
Promega UK Young Biochemist finalist - Lynne Marshall (Beatson Institute for Cancer Research, UK)
FACT facilitates rRNA gene chromatin transcription by RNA Polymerase I
Selected oral communication - Joost Zomerdijk (University of Dundee, UK)
EBV EBNA 2 stimulates transcriptional elongation through pTEFb and Spt5 recruitment to the EBV C promoter
Promega UK Young Biochemist finalist - Richard Palermo (University of Sussex, UK)
Expression of human snRNA genes from beginning to end
Shona Murphy (University of Oxford, UK)
TFIIB recognition elements control the pathway of transcription complex assembly
Stefan Roberts (University of Manchester, UK)
18:15 - 19:15 Drinks reception
Chair:
Steve Busby (University of Birmingham)
The Heatley Medal Lecture: What we have learned from high resolution structures of the ribosome
Venki Ramakrishnan (MRC LMB, Cambridge, UK)
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Transcription 2
Chair:
Doug Higgs (University of Oxford, UK)
09:00 - 10:30 Poster session 1
10:30 - 11:00 Coffee/tea break
Recruitment to the nuclear periphery can down-regulate transcription of human genes
Wendy Bickmore (MRC Human Genetics Unit, Edinburgh, UK)
Chromatin switching and transcriptional regulation in disease
Ian Wood (University of Leeds, UK)
Transcriptional determination of the Oct4 methylation pattern
Promega UK Young Biochemist finalist - Rodoniki Athanasiadou (University of Edinburgh, UK )
Methylation regulates the DNA, but not RNA, binding activity of ILF3
Selected oral communication - Matthew Guille (University of Portsmouth, UK)
Chromatin dynamics on active genes
Jane Mellor (University of Oxford, UK)
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Transcription 3
Chair:
Robert White (University of Glasgow, UK)
15:00 - 15:30 Coffee / Tea Break
Regulation of cell proliferation and apoptosis by NF-kB
Neil Perkins (University of Dundee, UK)
The DEAD box RNA helicase p68: a novel transcriptional co-regulator
Frances Fuller-Pace (University of Dundee, UK)
The serine protease HtrA2/Omi processes the Wilms¿ tumour suppressor WT1
Selected oral communication - Joerg Hartkamp (University of Manchester, UK)
Genome-wide analyses of transcriptional programmes in stem cells
Selected oral communication - Noel Buckley (Kings College London, UK)
A transcription factor code controlling proliferation, metastasis and differentiation
Colin Goding (Marie Curie Institute, Surrey, UK)
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Transcription 4
Chair:
Stefan Roberts (University of Manchester, UK)
The mechanism of alpha globin activation during erythropoiesis
Doug Higgs (University of Oxford, UK)
Progesterone Regulation of RUSH/SMARCA3 includes DNA looping
Selected oral communication - Beverly Chilton (TTUHSC, USA)
Transcriptional activation by targeted degradation of SUMO modified proteins
Ron Hay (University of Dundee, UK)
Overturning epigenetic silencing of the latent Epstein Barr Virus genome is achieved by interaction of a viral bZIP protein with a methylated CpG Motif
Selected oral communication - Alison Sinclair (University of Sussex, UK)
Combinatorial transcriptional regulation downstream from MAP kinase signalling cascades
Andy Sharrocks (University of Manchester, UK)
11:00 - 11:30 Coffee / tea break
Chair:
Steve Busby (University of Birmingham)
A model for all genomes: gene activation and repression
Plenary Lecture - Peter Cook (University of Oxford)
The Novartis Medal Lecture 2007: MeCP2 and Rett Syndrome
Plenary Lecture - Adrian Bird (University of Edinburgh, UK)
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Post-transcriptional control
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Post-transcription 1
Re-programming of protein synthesis following cell stress
Anne Willis (University of Nottingham, UK)
Translation of the HIV-2 genomic RNA occurs from 3 independent IRES that are controlled by the virally encoded protease and the Gag polyprotein
Selected oral communication - Emiliano Ricci (Laboratoire de Virologie Humaine, INSERM, France)
Contribution of internal initiation to translation of mRNA containing the leader sequence of maize ahcohol dehydrogenase gene
Selected oral communication - Evgeniya Mardanova (Centre ¿Bioengineering¿ RAS, Russia)
Subcellular localisation and its control for key steps in the protein synthetic pathway: blobs in translation
Mark Ashe (University of Manchester, UK)
Introns are required for efficient nonsense mediated mRNA decay in Schizosaccharomyces pombe
Promega UK Young Biochemist finalist - Jikai Wen (University of Birmingham, UK)
Cid1-dependent mRNA uridylation promotes decapping without deadenylation: a novel cytoplasmic mRNA turnover pathway?
Selected oral communication - Chris Norbury (University of Oxford, UK)
18:15 - 19:15 Drinks reception
Chair:
Steve Busby (University of Birmingham)
The Heatley Medal Lecture: What we have learned from high resolution structures of the ribosome
Venki Ramakrishnan (MRC LMB, Cambridge, UK)
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Post-transcription 2
09:00 - 10:30 Poster session 1
10:30 - 11:00 Coffee / tea break
Molecular airtraffic control during Eukaryotic translation initiation
Jon Lorsch (Johns Hopkins University, USA)
A reappraisal of translation initiation during the cell cycle
Selected oral communication - Markete Vlasak (University of Sussex, UK)
The HSV-1 ICP27 protein stimulates translation at an early stage
Selected oral communication - Richard Smith (IBLS, Glasgow University, UK)
Recycling eIF2 between rounds of translation initiation
Graham Pavitt (University of Manchester, UK)
An estimation of the global translational activity in logarithmically growing yeast cells
Selected oral communication - Tobias von der Haar (University of Kent, UK)
13:45 - 15:00 Poster Session 2
15:00 - 15:30 Coffee / Tea break
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Post-transcription 3
Chair:
Nicola Gray (MRC Human Genetics Unit, UK)
Sequential waves of polyadenylation and deadenylation define a translation circuit that drives meiotic progression
Raul Mendez (Centre de Regulacio Genomica, Barcelona, Spain)
Translational control in early development: CPEB, germinal granules and P bodies
Nancy Standart (University of Cambridge, UK)
Proteomic analysis of mRNA binding proteins during oogenesis
Selected oral communication - Helois Radford (University of Nottingham, UK)
Estrogen receptor beta expression is regulated by alternative 5¿UTRs
Promega UK Young Biochemist finalist - Laura Smith (University of Leeds, UK)
The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene
Selected oral communication - Ian Cannell (University of Nottingham, UK)
17:45 - 19:00 Poster Session 3
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Post-transcription 4
Chair:
Graham Pavitt (University of Manchester, UK)
Ribosomal acrobatics in post-transcriptional control
Robert Gilbert (University of Oxford, UK)
Dissection of a co-translational nascent chain separation event
Selected oral communication - Victoria Doronina (Newcastle University, UK)
Termination-Reinitiation in the Synthesis of Influenza BM2
Selected oral communication - Michael Powell (University of Cambridge, UK)
eIF3 plays a critical role in the reinitiation mechanism governing expression of yeast GCN4 by interacting with 5¿ sequences of uORF1 in its mRNA leader
Selected oral communication - Bela Szamecz (Laboratory of Regulation of Gene Expression, MBU AVCR, the Czech Republic )
RNA pseudoknots: versatile motifs in gene expression
Ian Brierley (University of Cambridge, UK)
11:00 - 11:30 Coffee / tea break
Chair:
Steve Busby (University of Birmingham, UK)
A model for all genomes: gene activation and repression
Plenary Lecture - Peter Cook (University of Oxford)
The Novartis Medal Lecture 2007: MeCP2 and Rett Syndrome
Plenary Lecture - Adrian Bird (University of Edinburgh, UK)
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New methods for the study of protein-nucleic acid interactions
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Single molecule techniques and kinetics
Chair:
Steve Busby (University of Birmingham, UK)
Single molecule approaches to studying RNA polymerase
Terence Strick (Paris, France)
Single-molecule micromanipulation studies of bacterial chromatin
Remus Dame (VU University, Amsterdam, The Netherlands)
Single-molecule DNA biosensors for transcription-factor detection
Achillefs Kapanidis (University of Oxford, UK)
Time-resolved footprinting for the study of the structural dynamics of protein-DNA interactions
Bianca Sclavi (Ecole Normale Supérieure de Cachan, France)
10:30 - 11:00 Coffee / tea break
11:00 - 13:00 Transcription and Post-transcription sessions take place
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In vivo techniques
Chair:
Marshall Stark (University of Glasgow, UK)
Visualising genetic loci and molecular machineries in living bacteria
Xindan Wang (University of Oxford, UK)
Methods for studying global patterns of DNA binding in bacteria
David Grainger (University of Birmingham, UK)
Mapping intracellular protein¿DNA interactions: a more robust and efficient alternative to ChIP (chromatin immunoprecipitation)
Selected oral communication - Marjeta Urh (Promega Corporation)
Computational approaches to study transcriptional regulation
Madan Babu (MRC-LMB, Cambridge, UK)
15:00 - 15:30 Coffee / tea break
15:30 - 17:30 Transcription and Post -transcription sessions take place
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New methods based on traditional biophysics
Chair:
Malcolm White (University of St Andrews, UK)
Calorimetry and hydrodynamic methods
David Scott (University of Nottingham, UK)
Higher throughput approaches to crystals and crystal structure determination
Tony Wilkinson (University of York, UK)
Visualising the organisation and re-organisation of transcription complexes for gene expression
Martin Buck (Imperial College London, UK)
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