Chairs:
Kevin Docherty (University of Aberdeen, UK)
Peter Jones (King's College London, UK)
Raphael Scharfmann (INSERM, Faculty Necker, France)
Decio Eizirik (Université Libre de Bruxelles, Belgium)
Organizers:
Jo Lilleystone (Juvenile Diabetes Research Foundation (JDRF), UK)
Guy Rutter (Imperial College London, UK)
Stephanie Amiel (King's College London, UK)
Decio Eizirik (Université Libre de Bruxelles, Belgium)
David Tosh (University of Bath, UK)
Peter Jones (King¿s College London,UK)
James AM Shaw (Newcastle University, UK)
David Dunger (University of Cambridge, UK)
Timetable
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Birth: beta-cell progenitors and differentiation
Chair:
Raphael Scharfmann (INSERM, Faculty Necker, France)
08:00 - 08:45 Registration with coffee/tea
08:45 - 09:00 Introduction by Karen Addington (Chief Executive JDRF UK), Guy Rutter (SaveBeta and Imperial College, UK) and Robert Goldstein (Chief Scientific Officer, JDRF International, USA)
The FoxO/A family in beta-cell development
Markus Stoffel (ETH Zurich, Switzerland)
Beta cell progenitor niche(s) and derivation of such cells from human ES cells
Henrik Semb (Lund University, Sweden)
Control of pancreas development by intercellular signals
Raphael Scharfmann (INSERM, Faculty Necker, France)
10:30 - 11:00 Coffee/tea break
EGF receptor signalling in islet development
Timo Otonkoski (University of Helsinki, Finland)
Beta-cell growth in adults
Pedro Herrera (University of Geneva Medical School, Switzerland)
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Life: what is a beta-cell?
Chair:
Kevin Docherty (University of Aberdeen, UK)
Insulin signalling in islets
Shanta Persaud (King's College London, UK)
Insulin secretion at the scale of individual granules and single molecules
Sebastian Barg (Imperial College London, UK)
Why expression of some genes is disallowed in beta-cells
Frans Schuit (University of Leuven, Belgium)
15:00 - 15:30 Coffee/tea break
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Genetics of Type 2 diabetes and MODY: lessons for the beta-cell
Chair:
Guy Rutter (Imperial College London, UK)
TCF7L2 controls insulin gene expression and insulin secretion
Selected oral communication - Merewyn Loder (Imperial College London, UK)
Re-inventing the operon: identification of a novel mechanism of transcription regulation in beta cells
Selected oral communication - Michael Walker (Weizmann Institute of Science, Rehovot, Israel)
The genetics of type 2 diabetes: lessons for type 1?
Philippe Froguel (Imperial College London, UK)
Glucokinase and other susceptibility genes for beta-cell dysfunction: the candidate approach
Anna Gloyn (University of Oxford, UK)
17:00 - 18:30 Poster session 1 with drinks reception
19:30 - 22:30 Meeting dinner
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Death: causes and execution - Type 1
Chairs:
Decio Eizirik (Université Libre de Bruxelles, Belgium)
Thomas Mandrup-Poulsen (Steno Diabetes Center, Denmark)
Determinants of pancreatic beta cell regeneration
Yuval Dor (The Hebrew University, Jerusalem, Israel)
Commonality in the genetic control of type 1 diabetes in humans and NOD mice
Linda Wicker (University of Cambridge, UK)
Activation of autoreactive CD8 T cells and mechanisms of islet beta cell damage in autoimmune diabetes
Susan Wong (University of Bristol, UK)
10:00 - 10:30 Coffee/tea break
Cytokines and the execution of beta-cell apoptosis
Decio Eizirik (Université Libre de Bruxelles, Belgium)
Cytokine signalling in the beta-cell: dual role for IFN-gamma
Chantal Mathieu (University of Leuven, Belgium)
Role of Nuclear Factor-kB in beta cell death
Danielle Melloul (The Hebrew University of Jerusalem, Israel)
Therapeutic potential of GLP-1 and type 1 diabetes
Plenary lecture: Daniel Drucker (University of Toronto, Canada)
12:30 - 14:00 Lunch and poster session 2
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Death: causes and execution - Type 2
Chair:
Danielle Melloul (The Hebrew University of Jerusalem, Israel)
Macrophages, cytokines and beta-cell death in type 2 diabetes
Marc Donath (University Hospital Zurich, Switzerland)
Oxidative stress: the vulnerable beta-cell
Sigurd Lenzen (Institute of Clinical Biochemistry, Germany)
Fatty acids and glucolipotoxicity
Miriam Cnop (Université Libre de Bruxelles, Belgium)
15:30 - 16:00 Coffee/tea break
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Revival
Chair:
Peter Jones (King's College London, UK)
Biphasic induction of PDX-1 in mouse embryonic stem cells can mimic development of pancreatic beta-cells
Selected oral communication - Andreia Sofia Bernardo (University of Aberdeen, UK)
Transdifferentiation of pancreatic ductal cells to beta cells: a model derived from the analysis of hnf6-/- mice
Selected oral communication - Patrick Jacquemin (de Duve Institute and Université catholique de Louvain, Belgium)
Transdifferentiation of pancreatic ductal cells to endocrine beta-cells
Susan Bonner-Weir (Harvard Medical School, Boston, USA)
Clinical islet transplantation
Stephanie Amiel (King's College London, UK)
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