Organizers:
Manuel S. Rodríguez (CICbioGUNE, Spain)
Gemma Marfany (University of Barcelona, Spain)
Dimitris Xirodimas (University of Dundee, UK)
Eduardo Salido (ITB, University of La Laguna, Spain)
Rosa Farràs (Centro de Investigación Príncipe Felipe, Spain)
Timetable
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Session 1: Lysosomal pathway
Chair:
Patricia Boya (CSIC, Spain)
Lysosomal control of tumor cell survival
Marja Jäättelá (Institute for Cancer Biology, Denmark)
Self-eating or self-killing: the essential dilemma of a stressed cancer cell
Guido Kroemer (CNRS, France)
The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium
Patricia Boya (Centro de Investigaciones Biológicas, CSIC, Spain)
11:00 - 11:30 Coffee/tea break
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Session 2: Ubiquitin and cell membrane associated degradation
Chair:
Eduardo Salido (ITB, University of La Laguna, Spain )
Versatile role of ubiquitin in the trafficking of yeast transporters
Naima Belgareh (Institute Jacques-Monod, France)
Protein quality control and degradation at the endoplasmic reticulum
Thomas Sommer (Max-Delbruck-Center for Molecular Medicine, Germany)
The role of a novel p97/VCP-interacting motif (VIM) in ER-associated degradation
Petek Ballar (University of Maryland Biotechnology Institute, USA )
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Session 3: Mechanisms of specificity of the ubiquitin proteasome pathway part 1
Chair:
Dimitris Xirodimas (University of Dundee, UK )
Targeting ubiquitin networks
Ivan Dikic (Goethe University, Germany)
E3-independent self-ubiquitination of Ub-binding proteins
Daniela Hoeller (Biocenter Innsbruck, Austria)
Development of TUBEs (Tandem Ubiquitin Binding Entities) to study ubiquitin dependent processes
Roland Hjerpe (CICbioGUNE, Spain)
15:45 - 16:15 Coffee/tea break
CHIP mediated degradation and DNA damage dependent stabilization regulates base excision repair proteins
Grigory L. Dianov (University of Oxford, UK)
In vivo biotinylation of neuronal ubiquitin substrates
Ugo Mayor (Wellcome Trust Cancer Research UK Gurdon Institute, Cambridge, UK )
Sunset poster session 1 and Welcome Drinks Reception
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Session 3: Mechanisms of specificity of the ubiquitin proteasome pathway part 2
Chair:
Christine Blattner (Institute of Toxicology and Genetics, Germany)
The ubiquitin-proteasome system in Epstein-Barr virus infected cells
Maria Masucci (Karolinska Institute, Sweden)
Identification of novel inhibitors of deubiquitinating enzymes
Seth Goldenberg (Progenra Inc, USA)
Functional characterization of several structural domains of the deubiquinating enzyme USP25
Amanda Denuc (University of Barcelona, Spain)
Regulation of separase: Securin-independent modes of regulating the giant protease that triggers anaphase
Olaf Stemmann (Max-Planck-Institute of Biochemistry, Germany)
Aggresome formation in response to Ala-Ala-Phe-chloromethylketone is independent of the inhibition of tripeptidyl peptidase II
Luis C. Antón (CSIC, Spain)
Are F-box proteins with a C-terminal domain homologous to the tobacco lectin involved in protein degradation in plants?
Els Van Damme (Ghent University, Belgium)
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Session 4: Regulation of transcription through the ubiquitin-proteasome pathway
Chair:
Marc Piechazyk (CNRS, France)
The ubiquitin ligase E6-AP and its role in human disease
Martin Scheffner (University of Konstanz, Germany)
SAMe-deficient tumor hepatocyte cell line (SAM-D) shows wild type and active p53 together with UV resistance
Nuria Martinez (CICbioGUNE, Spain.)
Role of ubiquitin and SUMO molecules in the regulation of the inhibitory function of IkBa on NFkB activity
Valerie Lang (CICbioGUNE, Spain)
15:45 - 16:15 Coffee/tea break
Coordinated deregulations of Fos-related antigen 1 and -2 proteasomal degradations in cancer cells
Marc Piechaczyk (CNRS, France )
JunB breakdown in G2 is required for proper mitosis
Rosa Farràs (Centro de Investigación Príncipe Felipe, Spain)
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Session 5: Ubiquitin-like molecules
Chair:
Gemma Marfany (University of Barcelona, Spain)
Role of poly-SUMO chains in targeting proteins for degradation
Ronald Hay (University of Dundee, UK)
The role of Sumoylation during Drosophila metamorphosis
Ana Talamillo (CICbioGUNE, Spain)
Drosophila transcriptional adaptor Ada3 as a target for SUMOylation in vivo
Benjamin Grau (CSIC, Spain)
10:30 - 11:00 Coffee/tea break
Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes
Guillaume Bossis (CNRS, France)
SUMO-binding domains are involved in the regulation of tumour suppressors by the Kaposi´s sarcoma-associated herpesvirus latent protein LANA2
Carmen Rivas (CSIC, Spain)
Ribosomal proteins; a novel target for the NEDD8 pathway
Dimitris Xirodimas (University of Dundee, UK)
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Session 6: Regulation of the proteasome activity
Chair:
Olivier Coux (CNRS, France)
A Mason's approach to the 19S regulatory particle of the proteasome
Michael Glickman (The Technion, Israel)
The ubiquitin ligase Mdm2 interacts with the 19S regulatory subunit of the proteasome
Roman Kulikov (Institute of Toxicology and Genetics, Germany)
Scaled-down purification of 20S proteasome from human tissue sample: application on normal and tumor colorectal cells
Sandrine Uttenweiler-Joseph (CNRS, France)
15:45 - 16:15 Coffee/tea break
Diversity of proteasomal missions: fine tuning of the immune response
Michael Groll (Munich Technical University, Germany)
Remodeling of the ubiquitin proteasome system in response to Interferons
Elke Krüger (Institute of Biochemistry, Germany)
Round table discussion and Conclusion
21:00 - 23:00 Gala dinner
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