Organizers:
Richard Boyd (University of Oxford, UK )
Deborah Goberdhan (University of Oxford, UK )
Richard Lamb (Institute of Cancer Research, UK)
09:30 - 10:30 Registration and coffee/tea
19:00 - 22:00 Meeting dinner at Brasenose College
21:00 - 23:00 Brasenose Bar open
Timetable
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Insulin/TOR signalling and translational control
Chair:
Richard Boyd (University of Oxford, UK)
Tissue-specific mTOR signalling
Michael Hall (University of Basel, Switzerland)
A complex relationship between the TSC1-TSC2 complex and the mTOR complexes
Brendan Manning (Harvard University, USA)
Hypoxia, mTOR, and tumor progression
Celeste Simon (University of Pennsylvania Cancer Center, USA)
TOR signalling regulates mitotic commitment through the stress MAPK and Polo kinase in response to nutrient availability
Selected oral communication - Janni Petersen (University of Manchester, UK)
The role of lipid biosynthesis in the regulation of cell growth by Protein Kinase B (PKB/Akt)
Selected oral communication - Almut Schulze (Cancer Research UK)
12:40 - 14:10 Lunch and poster session 1 (odd numbered posters)
Studies on the activation mechanism of the mTORC1 kinase
Joseph Avruch (Harvard University, USA)
mTOR signalling in the control of protein synthesis
Chris Proud (University of Southampton, UK)
p38 positively regulates growth and Tor signalling
Selected oral communication - Megan Cully (Cancer Research UK)
15:30 - 16:00 Coffee/tea break
Regulation of autophagy by TOR signalling in Drosophila
Thomas Neufeld (University of Minnesota, USA)
The Rag proteins mediate amino acid signalling to mTORC1
Selected oral communication - Yasemin Sancak (Massachusetts Institute of Technology, USA)
Form and flexibility in lipid kinases
Form and flexibility in lipid kinases
The Morton Lecture - Roger Williams (MRC, UK)
17:50 - 18:50 Drinks reception at MSTC
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Nutrient regulation of mTOR
Chair:
Joseph Avruch (Harvard University, USA)
Tuesday 16 September 2008
mTOR, immunity and nutrients
Richard Lamb (Institute of Cancer Research, UK)
Amino acid transporters:- the éminence grises of nutrient signalling mechanisms?
Peter Taylor (University of Dundee, UK)
Amino acid induced signalling via the SPS-sensing pathway in yeast
Per Ljungdahl (Stockholm University, Sweden)
10:30 - 11:00 Coffee/tea break
Heteromeric amino acid transporters: structure-function relationship
Manuel Palacin (University of Barcelona, Spain)
Proton-assisted amino acid transporters regulate growth and TOR signalling in normal and cancer cells via a novel intracellular mechanism
Deborah Goberdhan (University of Oxford, UK)
Ceramide starves cells to death
Aimee Edinger (University of California, Irvine, USA)
Prolyl hydroxylases as regulators of cell metabolism
Selected oral communication - Raul Duran (The Beatson Institute for Cancer Research, UK)
12:50 - 14:20 Lunch and poster session 2 (even numbered posters)
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The mTOR signalling pathway: physiology, pathology and treatments
Chair:
Michael Hall (University of Basel, Switzerland)
Tuesday 16 September 2008
AMPK, an ancient starvation signalling pathway that restrains cell growth
Grahame Hardie (University of Dundee, UK)
LKB1 and AMPK connect energy stress to mTOR
Reuben Shaw (The Salk Institute, USA)
Therapeutic targeting of mTOR in tuberous sclerosis
Julian Sampson (Cardiff University, UK)
15:50 - 16:20 Coffee/tea break
Regulation of amino acid transporters by glucose and growth factors in primary human trophoblast cells is mediated by mTOR signalling
Selected oral communication - Sara Roos (University of Gothenburg, Sweden)
Characterization of NVP-BEZ235, a dual PI3K/mTor catalytic inhibitor for cancer treatment
Michel Maira (Novartis, Switzerland)
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