Organizers:
Katherine Bowers (University College London, UK)
Juan Martin-Serrano (Kings College London, UK)
Paul Whitley (University of Bath, UK)
Timetable
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Session 1
Chair:
Jean Gruenberg (University of Geneva , Switzerland)
12:00 - 13:25 Registration and lunch
Welcome note and introduction from the Organizers
ESCRTs in control of receptor signalling and trafficking
Harald Stenmark (The Norwegian Radium Hospital, Norway)
David Katzmann (Mayo Clinic College of Medicine, USA)
ESCRT proteins, endosome organisation, and mitogenic receptor down-regulation
Philip Woodman (University of Manchester, UK)
Evolution of Ethe endocytic ubiquitylation system
Selected oral communication - Mark Field (University of Cambridge, UK)
K63-linked polyubiquitylation of the yeast Gap1 permease is required for its sorting into the multivesicular body pathway
Selected oral communication - Elsa Lauwers (Université Libre de Bruxelles, Belgium)
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Session 2
Chair:
Scott Emr (Cornell University, USA)
Evolution and assembly of ESCRTs
Roger Williams (University of Cambridge, UK)
Structures and function of ESCRT-III
Winfried Weissenhorn (UJF-EMBL-CNRS, Grenoble, France)
ESCRT structure: putting the pieces together
James Hurley (NIDDK, National Institutes of Health, USA)
X-ray crystal structural analysis of ALG-2/Alix peptide complex
Selected oral communication - Masatoshi Maki (Nagoya University, Japan)
Differential roles for Alix and ESCRT-III in cytokinesis and HIV-1 release
Selected oral communication - Jez Carlton (Kings College London, UK)
18:00 - 19:30 Poster session with drinks - odd numbers
ESCRT genetics and ubiquitin-dependent receptor sorting at the endosome
Plenary Lecture - Scott Emr (Cornell University, USA)
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Session 3
Chair:
Mark Marsh (University College London, UK)
PTP1B and EGF-stimulated intralumenal vesicle formation within multivesicular endosomes
Clare Futter (UCL Institute of Ophthalmology, UK)
CHMP6/ESCRTIII and the regulation of endocytic delivery to lysosomes
Paul Luzio (University of Cambridge, UK)
Fission and fusion events within endosomes
Jean Gruenberg (University of Geneva, Switzerland)
ALIX and ALG-2 form an adaptor complex for apical caspases on endocytosed death receptors
Selected oral communication - Rémy Sadoul (Université Joseph Fourier, France)
Plant CHMP1A and B proteins are involved in the MVB sorting of plant hormone efflux carriers and are required for embryo development
Selected oral communication - Marisa Otegui (University of Wisconsin, USA)
11:00 - 12:30 Poster session with coffee/tea - even numbers
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Session 4
Chair:
Wes Sundquist (University of Utah, USA)
Tools for probing the role of ubiquitin and ESCRT proteins in viral particle release
Paul Bieniasz (Aaron Diamond AIDS Research Center, USA)
Rescue of HIV budding by components of the ESCRT pathway
Heinrich Gottlinger (Harvard University, USA)
The HIV assembly compartment in human macrophages
Mark Marsh (University College London, UK)
The role of the ESCRT pathway in the assembly of herpesviruses
Selected oral communication - Colin Crump (University of Cambridge, UK)
The ubiquitin ligase Nedd4.1 rescues HIV-1 budding defects in an L Domain dependent manner
Selected oral communication - Fadila Bouamr (National Institutes of Health, USA)
19:30 - 21:00 Conference Dinner
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Session 5
Chair:
Paul Luzio (University of Cambridge, UK)
ESCRT function in early C. elegans development
Selected oral communication - Anjon Audhya (University of Wisconsin-Madison, USA)
Ambient pH signalling protease PalB associates with ESCRT-III via Vps24
Selected oral communication - Miguel A. Penalva (Centro de Investigaciones Biologicas, Spain)
Insights into the ancestral role of ESCRT proteins
Selected oral communication - Steve Bell (University of Oxford, UK)
Distinct genetic properties of ESCRT-II components in drosophila
Selected oral communication - Andreas Bergmann (MD Anderson Cancer Center, USA)
Essential role of hIST1 in cytokinesis
Selected oral communication - Monica Agromayor (Kings College London School of Medicine, UK)
Institute of Neurology London, UK
Frontotemporal dementia-causing CHMP2B mutants produce an enlarged endosomal phenotype and alter growth factor trafficking
Selected Oral Communication - Adrian Isaacs (Institute of Neurology London, UK)
Biochemical analyses of HIV budding
Plenary Lecture - Wesley Sundquist (University of Utah, USA)
11:45 - 11:50 Final Comments from the Organizers
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