Organizers:
Colin Bingle (University of Sheffield, UK)
Alan Wallace (AstraZeneca, UK)
Timetable
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Chronic inflammatory disease of the lung - overview
Chair:
Alan Wallace (AstraZeneca, UK)
09:00 - 10:30 Registration with coffee/tea
Debbie Hartman (AstraZeneca, UK)
Angiogenesis in asthmatic airway inflammation
Serpil Erzurum (The Cleveland Clinic Foundation, USA)
The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia
Tracy Hussell (Imperial College London, UK)
Lipid A structure of Pseudomonas aeruginosa LPS is responsible for pro-inflammatory response in cystic fibrosis epithelium
Selected oral communication - Paul Buchanan (Queens University, Belfast, UK)
Defective histone acetylation is responsible for the diminished expression of cyclooxygenase-2 in idiopathic pulmonary fibrosis
Selected oral communication - William Coward (University of Nottingham, UK)
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The genetics of lung disease
Chair:
Colin Bingle (University of Sheffield, UK)
What has genetics taught us about respiratory disease?
Ian Hall (University of Nottingham, UK)
Genetic variants of matrix metalloproteinases 1, 9 and 12 in chronic obstructive pulmonary disease
Selected oral communication - Imran Haq (University of Nottingham, UK)
Twins studies as a model for studies of interaction between smoking and genetic factors in the development of chronic bronchitis
Magnus Svartengren (Karolinska Institutet, Sweden)
15:10 - 15:40 Coffee/tea break
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Issues in COPD and asthma
Chair:
Serpil Erzurum (The Cleveland Clinic Foundation, USA)
Novel mechanisms in the pathogenesis of the local and systemic effects of COPD
William MacNee (The Queen's Medical Research Institute, Edinburgh, UK)
Identification of sputum proteins as biomarkers of chronic obstructive pulmonary disease (COPD)
Selected oral communication - Benjamin Nicholas (Southampton General Hospital, UK)
Cytoplasmic tail of IL-13Ra2 regulates IL-4 signal transduction
Selected oral communication - Allison-Lynn Andrews (University of Southampton, UK)
Overcoming steroid unresponsiveness in airways disease
Ian Adcock (Imperial College London, UK)
17:30 - 19:00 Drinks reception and poster session
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Tools for studying lung diseases
Chair:
Thomas Mariani (University of Rochester, USA)
Using in vivo zebrafish models to understand the biochemical basis of neutrophilic respiratory disease
Stephen Renshaw (University of Sheffield, UK)
ENU mutagenesis as a tool for understanding lung development and disease
Charlotte Dean (MRC Harwell, UK)
Critical role for STAT6 in regulating transcriptional programs leading to goblet cell formation in human airway epithelium
Selected oral communication - Jonathan Turner
10:30 - 11:00 Coffee/tea break
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Fibrosis and lung disease
Chair:
Ian Adcock (Imperial College London, UK)
Novel regulatory mechanisms for the CFTR gene
Ann Harris (Northwestern University, Chicago, USA)
IGFBP-5 induces epithelial and fibroblast responses consistent with a fibrotic response
Selected oral communication - David Flint (University of Strathclyde, UK)
Novel mechanisms and pathways in fibrotic lung disease
Gisli Jenkins (University of Nottingham, UK)
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Biomarkers and new therapies
Chair:
Ann Harris (Northwestern University, Chicago, USA)
Array of hope: expression profiling identifies disease biomarkers and mechanism
Thomas Mariani (University of Rochester, USA)
Potent anti-inflammatory effects of the highly selective iNOS inhibitor BYK402750 on cigarette smoke induced inflammation in mice
Selected oral communication - Christian Hesslinger (Nycomed GmbH, Germany)
The search for clinical markers in respiratory drug development
Paul Rugman (AstraZeneca, UK)
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