Organizers:
David Fell (Oxford Brookes University, UK)
Michael White (University of Liverpool, UK)
Hans Westerhoff (University of Manchester, UK)
12:30 - 14:00 Registration and lunch
Systems Biology in practice: modeling, and understanding regulation and control
Plenary Lecture - Hans Westerhoff (University of Manchester, UK)
Vicky Jackson (BBSRC, UK)
Structure-based systems biology of insulin and IGF-I receptor signal transduction
Plenary Lecture - Pierre De Meyts (Hagedorn Research Institute, Denmark)
12:30 Close of meeting and departure
Timetable
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Metabolism
16:00 - 16:30 Coffee/tea break
Structure, evolution and dynamics of transcriptional regulatory networks and its influence on genome organization
M Madan Babu - Early Career Researcher Award (University of Cambridge, UK)
19:00 - 21:00 Conference dinner
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Systems analysis of metabolism 1
12:30 - 14:00 Registration and lunch
Systems Biology in practice: modeling, and understanding regulation and control
Plenary Lecture - Hans Westerhoff (University of Manchester, UK)
Analyzing genome scale metabolic models
David Fell (Oxford Brookes University, UK)
15:50 - 16:20 Coffee/tea break
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Systems analysis of metabolism 2
Metabolic modelling and in silico predictions for bioprocess development in Streptomyces
Claudio Avignone-Rossa (University of Surrey, UK)
Predicting novel metabolic pathways in genome-scale networks
Stefan Schuster (Friedrich Schiller University of Jena, Germany)
Why does yeast ferment? A flux balance analysis study
Selected oral communication - Evangelos Simeonidis (University of Manchester, UK)
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Systems analysis of metabolism 3
Computational optimization and biological evolution: Similarities and differences
Igor Goryanin (University of Edinburgh, UK)
Beyond in vitro kinetics - identification of data driven dynamic models of metabolic networks
Matthias Reuss (University of Stuttgart, Germany)
Using control analysis to understand the design principles of biological systems
Guy Brown (University of Cambridge, UK)
11:00 - 11:30 Coffee/tea break
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Systems analysis of metabolism 4
Systems biology of protein secretion in Saccharomyces cerevisiae: mapping of global regulatory structure
Keith Tyo (Chalmers University of Technology, Sweden)
Context and content of the yeast metabolic network
Steve Oliver (University of Cambridge, UK)
12:50 - 13:05 BJ Semantic
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Systems analysis of metabolism 5
Modelling the peroxisomal carbon leak during lipid mobilization in Arabidopsis
Selected oral communication - Mark Hooks (Bangor University, UK)
Dynamic modelling of anaerobic yeast metabolism: involvement of salvage reactions in dynamics of energy metabolism
Selected oral communication - Maksim Zakhartsev (University of Stuttgart, Germany)
15:00 - 17:00 Poster Session
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Systems analysis of metabolism 6
A stochastic approach of the electron transport in the mitochondrial respiratory chain
Jean-Pierre Mazat (University of Bordeaux, France)
Imaging metabolism using hyperpolarized 13C NMR
Kevin Brindle (University of Cambridge, UK)
10:20 - 10:50 Coffee/tea break
Vicky Jackson (BBSRC, UK)
Structure-based systems biology of insulin and IGF-I receptor signal transduction
Plenary Lecture - Pierre De Meyts (Hagedorn Research Institute, Denmark)
12:30 Close of meeting and departure
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Signalling
16:00 - 16:30 Coffee/tea break
Structure, evolution and dynamics of transcriptional regulatory networks and its influence on genome organization
M Madan Babu - Early Career Researcher Award (University of Cambridge, UK)
19:00 - 21:00 Conference dinner
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Signalling and control from a systems perspective and Systems approaches to health and disease 1
Apoptosis pathways in human malignancies
Boris Zhivotovsky (Karolinska Institute, Sweden)
15:50 - 16:20 Coffee/tea break
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Signalling and control from a systems perspective 2
Signalling in space and time
Boris Kholodenko (University College Dublin, Ireland)
System-level feedbacks control cell cycle progression
Bela Novak (University of Oxford, UK)
Sperm chemotaxis is tuned by spatio-temporal timing of calcium fluctuations
Selected oral communication - Adan Guerrero (National Autonomous University of Mexico, Mexico)
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Signalling and control from a systems perspective 3
Understanding the complex circuit of the circadian clock
Andrew Millar (University of Edinburgh, UK)
Growing pains: systems analysis of plant cell expansion
Malcolm Bennett (Centre for Plant Integrative Biology, University of Nottingham, UK)
Understanding root hair development using modelling and experiments
Claire Grierson (University of Bristol, UK)
11:00 - 11:30 Coffee/tea break
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Signalling and control from a systems perspective 4
Spatial and temporal information-coding and noise in the NF-κB system
Michael White (University of Liverpool, UK)
Coupling of transcription and splicing in yeast
Jean Beggs (University of Edinburgh, UK)
12:50 - 13:05 BJ Semantic
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Signalling and control from a systems perspective 5
Systems biochemistry approaches to vertebrate phototransduction: toward a molecular understanding of disease
Selected oral communication - Daniele Dell'Orco (University of Oldenburg, Germany)
Structure-based mathematical modeling of the insulin receptor kinetics and activation
Selected oral communication - Vladislav Kiselyov (Hagedorn Research Institute, Denmark)
15:00 - 17:00 Poster Session
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Signalling and control from a systems perspective 6
Information integration in signalling networks
Edda Klipp (Humboldt University Berlin, Germany)
Feedback control architecture and the chemotaxis network in Rhodobacter sphaeroides
Mark Roberts (University of Oxford, UK)
10:20 - 10:50 Coffee/tea break
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Systems approaches to health and disease 2
Uncovering general design principles for information processing through signalling networks
Ursula Klingmüller (German Cancer Research Centre, Germany)
Mathematical modelling of Wnt/ beta-Catenin signalling
Jana Wolf (Max Delbrück Centre for Molecular Medicine, Germany)
Modelling the effects of inhibitors of guanine nucleotide synthesis – implications for studies of cellular differentiation pathways
Selected oral communication - Geraint Thomas (University College London, UK)
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Systems approaches to health and disease 3
Systems biology of the TB bacillus: what does the pathogen eat?
Johnjoe McFadden (University of Surrey, UK)
Systems analysis of bacterial glycomes
Brendan Wren (London School of Hygiene and Tropical Medicine, UK)
Systems Biology from microorganisms to human metabolic diseases
Barbara Bakker (University Medical Centre Groningen, The Netherlands)
11:00 - 11:30 Coffee/tea break
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Systems approaches to health and disease 4
Metabolic adaptations in multifactorial diseases as targets for novel therapies
Marta Cascante (University of Barcelona, Spain)
Systems-guided design of novel ErbB targeted therapeutics
Brian Harms (Merrimack Pharmaceuticals, USA)
12:50 - 13:05 BJ Semantic
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Systems approaches to health and disease 5
System analysis of the effect of various drugs on cardiac contraction energetics
Selected oral communication - Philippe Diolez (Victor Segalen Bordeaux 2 University, France)
Large errors in metabolic labelling pulse-chase experiments that are corrected by a mathematical model: an application to mitochondrial turnover measurements in vivo
Selected oral communication - Satomi Miwa (Newcastle University, UK)
15:00 - 17:00 Poster Session
16:00 - 16:30 Coffee/tea break
Structure, evolution and dynamics of transcriptional regulatory networks and its influence on genome organization
M Madan Babu - Early Career Researcher Award (University of Cambridge, UK)
19:00 - 21:00 Conference dinner
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Systems approaches to health and disease 6
Glycomics of host-pathogen interactions
Anne Dell (Imperial College London, UK)
Robustness and frailty: the systems biochemistry of longevity and ageing
Tom Kirkwood (Newcastle University, UK)
10:20 - 10:50 Coffee/tea break
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