Organizers:
Ian Zachary (University College London, UK)
Sreenivasan Ponnambalam (University of Leeds, UK)
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Angiogenic signalling
Chairs:
David Bates (University of Bristol, UK)
David Shima (University College London, UK)
12:00 - 14:00 Registration with lunch
A unique signaling of VEGF family members, VEGF-A and VEGF-E
Masabumi Shibuya (University of Tokyo, Japan)
VEGF resistance as a novel concept
Johannes Waltenberger (Maastricht University, The Netherlands)
15:30 - 16:00 Coffee/tea break
Nitric oxide synthase inhibitors regulate VEGF-mediated angiogenesis
Selected oral communication - Lorna Fiedler (University College London, UK)
Signalling through Neuropilin-1
Ian Zachary (University College London, UK)
The transcription factor Erg regulates angiogenesis, endothelial homeostasis and cell migration
Selected oral communication - Graeme Birdsey (Imperial College London, UK)
Protease activated receptors and regulation of endothelial cell function: a role for cyclooxygenases
Caroline Wheeler-Jones (Royal Veterinary College, London, UK)
17:30 - 19:00 Welcome drinks reception with poster session one
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Endothelial receptor trafficking
Chairs:
Paolo Madeddu (University of Bristol, UK)
Ian Zachary (University College London, UK)
Endocytic trafficking in angiogenesis
Harry Mellor (University of Bristol, UK)
ERK5 regulates VEGF-mediated cell survival and tubular morphogenesis in primary human microvascular endothelial cells
Selected oral communication - Michael Cross (University of Liverpool, UK)
A role for protein ubiquitination in VEGFR-2 signaling and angiogenesis
Nader Rahimi (Boston Univsity, USA)
Reduced NFAT-dependent VEGFR-1 expression causes abnormal VEGF signaling in hemangiomas
Selected oral communication - Eileen Boye (Harvard School of Dental Medicine, USA)
Regulation of VEGFR2 trafficking and proteolysis in endothelial cells
Sreenivasan Ponnambalam (University of Leeds, UK)
11:00 - 11:30 Coffee/tea break
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Angiogenic mechanisms in disease
Chairs:
Johannes Waltenberger (Maastricht University, The Netherlands)
Sreenivasan Ponnambalam (University of Leeds, UK)
Seppo Yla-Herttuala (Kuopio University, Finland)
Neuropilin-1 crosstalk with PDGF receptors
Selected oral communication - Cay Kielty (University of Manchester, UK)
Structure-function analysis of the VEGF-A HBD reveals diverse roles in development and disease
David Shima (University College London, UK)
12:45 - 14:00 Lunch with poster session two
The antiangiogenic isoforms of VEGF in health and disease
David Bates (University of Bristol, UK)
VE-cadherin suppresses sprouting via signalling to MLC2 phosphorylation
Selected oral communication - Sabu Abraham (Cancer Research UK)
Functionally defining the endothelial transcriptome, from Robo4 to ECSCR
Roy Bicknell (University of Birmingham, UK)
Kinome profiling as an indicator for the angiogenic status of low-grade paediatric astrocytomas
Selected oral communication - Arend Hendrik Sikkema (University Medical Center Groningen, The Netherlands)
15:30 - 16:00 Coffee/tea break
Endothelial a3b1-integrin represses pathological angiogenesis and sustains endothelial-VEGF
Kairbaan Hodivala-Dilke (Barts and The London School Of Medicine and Dentistry, UK)
Molecular regulation of collecting lymphatic vessel formation
Taija Makinen (Cancer Research UK)
18:00 - 19:30 Conference Dinner
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Stem cells and developmental angiogenesis
Chairs:
Nadar Rahimi (Boston University, USA)
Asif Ahmed (University of Birmingham, UK)
Thymosin β4 induces epicardium-derived neovascularization in the adult heart
Paul Riley (University College London, UK)
Arterial/venous segregation by selective cell sprouting
Selected oral communication - Shane Herbert (University of California, San Francisco, USA)
Diabetic microangiopathy involves bone marrow microenvironment disrupting stem cell homeostasis
Paolo Madeddu (University of Bristol, UK)
Endothelial Thymosin Beta 4 acts during vascular development to facilitate mural cell recruitment to the vessel wall
Selected oral communication - Alex Rossdeutsch (The Babraham Institute, UK)
10:30 - 11:00 Coffee/tea break
Neuropilin ligands in neuronal and vascular patterning
Christiana Ruhrberg (University College London, UK)
Stalking your neighbour to reach the tip-VEGFRs and Notch
Lars Jakobsson (Cancer Research, UK)
Can the biology of VEGF and heme oxygenases help solve preeclampsia?
Asif Ahmed (University of Birmingham, UK)
Meeting close - concluding remarks
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