Organizers:
Matthew Brook (University of Edinburgh, UK)
Mark Coldwell (University of Southampton, UK)
Simon Morley (University of Sussex, UK)
Nicola Gray (University of Edinburgh, UK)
12:00 - 13:30 Registration and lunch
13:30 - 13:45 Organizers' opening address
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Subcellular mRNP localisation
Function and mechanism of RNA localisation and nonsense-mediated RNA decay in development
Isabel Palacios (University of Cambridge, UK)
Localization of mRNA to the endoplasmic reticulum overcomes sequestration into stress granules
Selected oral communication - Ernesto Yague (Imperial College London, UK)
Mitochondria associate with P-bodies and modulate RNA interference
Selected oral communication - Dominique Weil (André Lwoff Institute, France)
Localised synthesis of a plant viral RNA facilitates its intercellular transport
Selected oral communication - Jens Tilsner (University of Edinburgh, UK)
Visualization of ribosomal subunits interaction
Selected oral communication - Saverio Brogna (University of Birmingham, UK)
15:35 - 17:15 Poster Session 1
The regulation of mRNA turnover in human cells
Plenary speaker - Jens Lykke-Andersen (University of California San Diego, USA)
20:00 - 21:30 Poster Session 2
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Translation 1
Manipulation of the host translation initiation complex eIF4F by DNA Viruses
Derek Walsh (Dublin City University, Ireland)
Dissecting the initiation factor requirements for translation initiation on calicivirus mRNA
Selected oral communication - Azimah Abdul Wahab (University of Surrey, UK)
A new type of IRES in HIV
Selected oral communication - Nathalie Chamond (University Paris Descartes, France)
Specific requirements for miR-122 regulation of hepatitis C virus
Selected oral communication - Catherine Jopling (University of Nottingham, UK)
Termination-Reinitiation in the sythesis of influenza BM2
Selected oral communication - Michael Powell (University of Cambridge, UK)
10:50 - 11:20 Coffee/tea break
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Translation 2
3’ UTR-mediated mRNA-specific translational activation in germ cells
Nicola Gray (University of Edinburgh, UK)
ePABP phosphorylation is required for X. Laevis oocyte maturation
Matt Brook (University of Edinburgh, UK)
Cytoplasmic polyadenylation complexes in the C. elegans germ line
Selected oral communication - Christian Eckmann (Max Planck Institute, Germany)
miR483: A microRNA involved in nutritional foetal reprogramming, adipocyte differentiation and the metabolic syndrome
Selected oral communication - David Ferland McCollough (University of Nottingham, UK)
A role for eEF1A2 in motor neuron degeneration
Selected oral communication - Lowri Griffiths (University of Edinburgh, UK)
CD40 signalling inhibits translation of Bcl2 mRNA in Chronic Lymphocytic Leukaemia (CLL) cells at the post-initiation stage
Selected oral communication - Shaun Willimott (University of Leicester, UK)
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Translation 3
Chair:
Sarah Mohammed-Qureshi
Programmed frameshifting is a consequence of non-cognate stop codons in human mitochondrial ribosomes
Zofia Chrzanowska-Lightowlers (Newcastle University, UK)
Recoding by 2A peptides can be driven by many different interactions with the ribosomal tunnel
Selected oral communication - Fu Yan (Newcastle University, UK)
Remodelling of PTB-containing complexes is required for IRES-mediated translation during apoptosis
Selected oral communication - Helen King (University of Nottingham, UK)
FRET studies reveal conformational changes in the yeast 43S and the kinetics of the binding of eIF3
Selected oral communication - Pedro Juanes (University of Manchester, UK)
Translational de-regulation in Non Hodgkin Lymphoma
Selected oral communication - Emilie Horvilleur (University of Nottingham, UK)
16:20 - 17:00 Coffee/tea break
Translational control of synaptic plasticity
Keynote Speaker - Joel Richter (University of Massachusetts, USA)
18:00 - 19:00 "Funding your research independence" workshop
19:00 - 20:30 Poster session 3 with drinks reception (19:45)
20:30 - 23:00 Conference dinner
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Translation and mRNA turnover
Large complexes involved in post-transcriptional regulation of gene expression
Lori Passmore (MRC Laboratory of Molecular Biology Cambridge, UK)
Myc oncogene-induced cell proliferation requires upregulation of mRNA cap methylation
Selected oral communication - Victoria Cowling (University of Dundee, UK)
Pat proteins involvement in maternal CPEB RNP and P-bodies
Selected oral communication - Aline Marnef (University of Cambridge, UK)
Genome-wide analysis of mRNA decay patterns during early Drosophila development
Selected oral communication - Stefan Thomsen (University of Sussex, UK)
Analysis of microRNA-mediated post-transcriptional regulation with the FunREG method
Selected oral communication - Christophe Grosset (University Bordeaux 2, France)
10:50 - 11:30 Coffee/tea break
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mRNA turnover
Understanding the mechanism of mRNA degradation in the nonsense-mediated decay pathway
Selected oral communication - Pamela Nicholson (University of Berne, Switzerland)
Uncovering post-transcriptional regulation of MHC class I by a novel RNA-binding E3 ligase
Selected oral communication - Florencia Cano (University of Cambridge, UK)
Post-transcriptional gene control in human articular chondrocytes exposed to hyperosmolarity exposed to hyperosmolarity
Selected oral communication - Simon Tew (University of Liverpool, UK)
Translational control of TNFα cytokine mRNA mediated by MK2
Selected oral communication - Christopher Tiedje (Hannover Medical School, Germany)
Constitutive phosphorylation of the ELAV-protein HuR by PKCd propagates tumor relevant functions in colon carcinoma cells
Selected oral communication - Wolfgang Eberhardt (University of Frankfurt, Germany)
13:10 - 13:30 Closing remarks
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