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Signalling 2011: A Biochemical Society Centenary Celebration

8—10 June 2011

University of Edinburgh, UK



Meeting background
This multi-focus meeting on current topics in Signal Transduction will form a landmark in the Centenary Celebrations of the Biochemical Society in 2011 and will therefore represent the major diary event for the majority of British laboratories with an interest in Signalling Research.
 
The principle aim of this meeting is to sum up the advances in signal transduction research towards the end of the last century and highlight how this continues to pave the way for future advances in biology and medicine. These seminars will therefore reflect the current multi-disciplinary nature of modern Signal Transduction Research and will incorporate discussion of a broad range of experimental approaches, from protein structure, through cell and systems biology to human physiology, and how these new strategies are paving the way for novel therapeutics based on the manipulation of intracellular signalling pathways.
 
The meeting schedule therefore encapsulates both our current understanding of “traditional” areas of signal transduction research, such as lipid/protein phosphorylation and regulation of cell responses to second messengers (cyclic AMP and calcium), as well as advances in more “contemporary” receptor-activated, molecular processes underlying cell regulation (such as regulation of small G-proteins, ubiquitinylation and SUMOlation of signalling proteins and novel, developmental signalling pathways). The attendee will therefore gain a real insight into our current understanding of modern signal transduction, in terms of regulation of the activity of cell surface receptors to “downstream” targets associated with particular intracellular organelles. Given this scope of topics the target audience will encompass a broad range of researchers at different career stages, including those from both academic and industrial backgrounds.
 

Organizers:
Stephen Yarwood (University of Glasgow, UK)
Alan Wallace (AstraZeneca, UK)
Jeff McIlhinney (University of Oxford, UK)
Sandip Patel (University College London, UK)
Simon Morley (University of Sussex, UK)
Simon Cook (The Babraham Institute, UK)
Nicholas Brindle (University of Leicester, UK)
Susan Pyne (University of Strathclyde, UK)
Colin Taylor (University of Cambridge, UK)
Wednesday 8 June 2011
11:30 - 13:00 Registration with lunch

Timetable

Wednesday 8 June 2011Thursday 9 June 2011Friday 10 June 2011
13:00 - 14:00
Biochemical Society Centenary Award Lecture

14:00 - 16:30
New advances in cyclic AMP signalling

14:00 - 16:30
Lipid signalling

14:00 - 16:30
RTKs and MAP kinase signalling

16:45 - 17:30
Plenary Speaker

09:00 - 10:00
The Biochemical Society Award

10:00 - 12:30
New advances in cyclic AMP signalling - part II

10:00 - 12:30
Lipid signalling - part II

10:00 - 16:30
RTKs and MAP kinase signalling - part II

14:00 - 16:30
Signalling interactions involving intracellular calcium

14:00 - 16:30
Future directions in signalling

16:45 - 17:30
Plenary Speaker

09:00 - 10:00
Early Career Research Award

10:00 - 14:30
Systems analysis of signalling systems

10:00 - 14:30
Future directions in signalling - part II

10:00 - 14:30
Signalling interactions involving intracellular calcium - part II


Biochemical Society Centenary Award Lecture

 

Wednesday 8 June 2011
13:00 - 14:00
Biochemical Society Centenary Award
Signalling to the translation initiation machinery
Nahum Sonenberg (McGill University, Canada)

New advances in cyclic AMP signalling

 

Chair:
Stephen Yarwood (University of Glasgow, United Kingdom)
Wednesday 8 June 2011
14:00 - 14:30
Novel Control of Cyclic AMP-regulated Transcription in Vascular Endothelial Cells
Stephen Yarwood (University of Glasgow, United Kingdom)
14:30 - 15:00
The structure of the EPAC2/Rap1 signalling complex
Holger Rehmann (University Medical Center Utrecht, The Netherlands)
15:00 - 15:30 Coffee/tea break

15:30 - 15:45
The search for novel GPR119 agonists
Selected oral communication - Jinzhi Zhang (Pfizer R&D, United Kingdom)
15:45 - 16:00
Attempts to improve an Epac2-based sensor for cAMP
Selected oral communication - Katy Everett (University of Cambridge, United Kingdom)
16:00 - 16:30
Compartmentalisation of cyclic AMP signalling
Manuela Zaccolo (University of Glasgow, United Kingdom)

RTKs and MAP kinase signalling

 

Chair:
Nicholas Brindle (University of Leicester, United Kingdom)
Wednesday 8 June 2011
14:00 - 14:30
Allostery and signalling in ErbB receptors
Linda Pike (Washington University School of Medicine, U.S.A)
14:30 - 15:00
Neuropilin presentation of VEGF in cis directs specific signaling with consequence for tumor growth.
Sina Koch (Uppsala University, Sweden)
15:00 - 15:30 Coffee/tea break

15:30 - 15:45
Human-EGFR aligned on the plasma membrane adopts key features of Drosophila-EGFR asymmetry
Selected oral communication - Selene Roberts (Science and Technology Facilities Council, United Kingdom)
15:45 - 16:00
Novel peptide inhibitor of the juxtamembrane domain of the epidermal growth factor receptor
Selected oral communication - Aislyn Boran (Mount Sinai School of Medicine, U.S.A)
16:00 - 16:30
Feedback regulation of network signalling and its breakdown in human tumors
Yosef Yarden (The Weizmann Institute, Israel)

Lipid signalling

 

Chair:
Susan Pyne (University of Strathclyde, United Kingdom)
Wednesday 8 June 2011
14:00 - 14:30
Regulation of the Nuclear Hormone Receptor PPARg by Lysophosphatidic Acids
Gabor Tigyi (University of Tennessee Health Science Center, U.S.A)
14:30 - 15:00
GPR55: a novel lipid-sensing G protein-coupled receptor
Andrew Irving (University of Dundee, United Kingdom)
15:00 - 15:30 Coffee/tea break

15:30 - 15:45
Dissecting "non-genomic" progesterone signaling – insights from a yeast-based system.
Selected oral communication - Patricia Moussatche (FfAME, U.S.A)
15:45 - 16:00
Novel role for Hog1 MAP kinase in the metabolic control of phosphoinositide signaling at the Golgi
Selected oral communication - Peter Mayinger (Oregon Health and Science University, U.S.A)
16:00 - 16:30
How phosphatidylinositol 3-phosphate controls growth and autophagy
Nicholas Ktistakis (Babraham Institute, United Kingdom)

Plenary Speaker

 

Wednesday 8 June 2011
16:45 - 17:30
Signalling Involving PI3 Kinase
Doreen Cantrell (University of Dundee, United Kingdom)
17:30 - 19:00 Drinks reception with poster session 1

The Biochemical Society Award

 

Thursday 9 June 2011
09:00 - 10:00
The Biochemical Society Award
Inositol trisphosphate (InsP3) and Calcium Signaling
Michael Berridge (Babraham Institute, United Kingdom)

New advances in cyclic AMP signalling - part II

 

Chair:
Stephen Yarwood (University of Glasgow, United Kingdom)
Thursday 9 June 2011
10:00 - 10:30
A major role for cAMP signalling in mammalian circadian timekeeping
John O’Neill (University of Cambridge, United Kingdom)
10:30 - 10:45
AKAP-Lbc Scaffolding of PKA Facilitates Cardioprotective Phosphorylation of Hsp20
Selected oral communication - Helen Edwards (University of Glasgow, United Kingdom)
10:45 - 11:00
Unbiased identification of substrates for the Epac1-inducible E3 ubiquitin ligase component SOCS3.
Selected oral communication - Jamie Williams (University of Glasgow, United Kingdom)
11:00 - 11:30 Coffee/tea break

11:30 - 12:00
Functional role of the cyclic AMP-binding protein Epac in heart
Frank Lezoualc'h (Inserm, France)
12:00 - 12:30
Mapping cAMP signaling networks in EPAC through the covariance analysis of NMR chemical shifts
Selected oral communication - Giuseppe Melacini (McMaster University, Canada)

RTKs and MAP kinase signalling - part II

 

Chair:
Nicholas Brindle (University of Leicester, United Kingdom)
Thursday 9 June 2011
10:00 - 10:30
The nuclear consequences of MAP kinase pathway signalling
Andrew Sharrocks (University of Manchester, United Kingdom)
10:30 - 10:45
The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by diverse agonists and regulates responsiveness of Tie2 to its ligand
Selected oral communication - Harprit Singh (University of Leicester, United Kingdom)
10:45 - 11:00
GnRH mediates nuclear accumulation of ERK by mechanisms additional to TEY phosphorylation that are dependent on the CD motif and PKC
Selected oral communication - Christopher Caunt (University of Bath, United Kingdom)
11:00 - 11:30 Coffee/tea break

11:30 - 12:00
Regulation of MEK/ERK pathway output by subcellular localisation of BRAF
Catrin Pritchard (University of Leicester, United Kingdom)
12:00 - 12:30
Tumour cell responses to MEK1/2 inhibitors – acquired resistance and pathway remodelling
Simon Cook (Babraham Institute, United Kingdom)
12:30 - 14:00 Lunch with poster session 2

14:00 - 14:30
Signal transduction by the JNK pathway
Roger Davis (University of Massachusetts Medical School, U.S.A)
14:30 - 14:45
Inhibition of Ras-dependent cellular transformation by transcription factors ATF2 & 7
Selected oral communication - Wolfgang Breitwieser (Paterson Institute for Cancer Research, United Kingdom)
14:45 - 15:00
Deletion of the DUSP-4 (MKP-2) gene decreases fibroblast proliferation and enhances apoptosis
Selected oral communication - Robin Plevin (University of Strathclyde, United Kingdom)
15:00 - 15:30 Coffee/tea break

15:30 - 16:00
Signal integration by p38 MAP kinases
Angel Nebreda (Institute for Research in Biomedicine [IRB Barcelona] Spain)
16:00 - 16:30
MKK4 and MKK7 are promising therapeutic targets
Cathy Tournier (University of Manchester, United Kingdom)

Lipid signalling - part II

 

Chair:
Susan Pyne (University of Strathclyde, United Kingdom)
Thursday 9 June 2011
10:00 - 10:30
PKB/Akt-mediated phosphorylation of Twist1 is crucial for breast cancer metastasis
Brian Hemmings (Friedrich Miescher Institute for Biomedical Research, Switzerland)
10:30 - 10:45
In vivo Activation Dynamics of PDK1 and PKB
Selected oral communication - Veronique Calleja (Cancer Research, United Kingdom)
10:45 - 11:00
PI3Kdelta inhibition: a future paradigm for the inhaled therapy of asthma?
Selected oral communication - Augustin Amour (GlaxoSmithKline, United Kingdom)
11:00 - 11:30 Coffee/tea break

11:30 - 12:00
Sphingosine 1-phosphate signalling in cancer
Nigel Pyne (University of Strathclyde, United Kingdom)
12:00 - 12:30
The glycerophosphoinositols in the inflammatory response
Daniela Corda (Institute of Protein Biochemistry, Italy)

Signalling interactions involving intracellular calcium

 

Chair:
Sandip Patel (University College London, United Kingdom)
Thursday 9 June 2011
14:00 - 14:30
Localisation of Ca2+ release and Ca2+ influx in polarised secretory cells: cellular geography and physiological consequences.
Alexi Tepikin (University of Liverpool, United Kingdom)
14:30 - 14:45
An AC8/Orai1 signalling complex underlies dynamic Ca2+-regulated cAMP signalling
Selected oral communication - Debbie Willoughby (University of Cambridge, United Kingdom)
14:45 - 15:00
In vitro synaptogenesis in rat hippocampal primary neurons is associated with the onset of spontaneous intracellular Ca2+ oscillations and increases in the expression of Ca2+ signalling proteins.
Selected oral communication - Esther Seung-kyung Kang (Babraham Institute, United Kingdom)
15:00 - 15:30 Coffee/tea break

15:30 - 16:00
Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes
Nicolas Demaurex (University of Geneva, Switzerland)
16:00 - 16:30
Physiological functions of store-operated calcium entry
Jim Putney (National Institutes of Health, U.S.A)

Future directions in signalling

 

Chair:
Simon Morley (University of Sussex, United Kindgom)
Thursday 9 June 2011
14:00 - 14:30
Arl proteins and regulation of transport of prenylated proteins
Alfred Wittinghofer (Max Planck Institute of Molecular Physiology, Germany)
14:30 - 14:45
Determining the role of extracellular signal-regulated kinase 5 (ERK5) down-stream of oncogenic Ras and Raf in colorectal cancer.
Selected oral communication - Pamela Lochhead (Babraham Institute, United Kingdom)
14:45 - 15:00
Involvement of phosphatidylinositol 5-phosphate in insulin signalling in the skeletal muscle cell line L6
Selected oral communication - Katherine Hinchliffe (University of Manchester, United Kingdom)
15:00 - 15:30 Coffee/tea break

15:30 - 16:00
Mammalian Hippo signalling: a kinase network regulated by protein-protein interactions
Alexander Hergovich (University College London, United Kingdom)
16:00 - 16:15
Calcium-sensitisation of human myometrial contractility: ROCK-dependent phosphorylation of myosin phosphatase targeting subunit (MYPT1) is associated with in vitro phasic contractions.
Selected oral communication - Claire Hudson (University of Bristol, United Kingdom)
16:15 - 16:30
The small GTPase Rif triggers formation of actin stress fibre in epithelial cells
Selected oral communication - Lifei Fan (University of Bristol, United Kingdom)

Plenary Speaker

 

Thursday 9 June 2011
16:45 - 17:30
Cell migration and invasion in human disease
Sara Courtneidge (Sanford-Burnham Medical Research Institute, U.S.A)
17:30 - 18:45 Drinks reception

19:00 - 23:00 Conference Dinner at The Hub with Ceilidh

Early Career Research Award

 

Friday 10 June 2011
09:00 - 10:00
Early Career Research Award
Dynamic clustering of IP3 receptors by IP3 – drying the timbers for the bush-fire
Taufiq Rahman (University of Cambridge, United Kingdom)

Systems analysis of signalling systems

 

Chair:
Alan Wallace (AstraZeneca, United Kingdom)
Friday 10 June 2011
10:00 - 10:30
Multi-pathway network analysis of human epithelial cell responses in inflammatory environments
Douglas Lauffenburger (Massachusetts Institute of Technology, U.S.A)
10:30 - 10:45
Decoding GnRH neurohormone pulse frequency by convergent signalling modules
Selected oral communication - Craig McArdle (University of Bristol, United Kingdom)
10:45 - 11:00
Upscaling cellular signalling models to the tissue-scale: a concurrent systems approach
Selected oral communication - Adam Sampson (University of Abertay Dundee, United Kingdom)
11:00 - 11:30 Coffee/tea break

11:30 - 12:00
Differential spatial dynamics of MAP-kinase activation in striatal neurons
Susana Neves (Mount Sinai School of Medicine, U.S.A)
12:00 - 12:30
Signalling ballet in four dimensions
Boris Kholodenko (University College Dublin, Ireland)
12:30 - 13:30 Lunch

13:30 - 13:45
Model-based global sensitivity analysis as applied to explore signal propagation through cancer-related networks
Selected oral communication - Galina Lebedeva (University of Edinburgh, United Kingdom)
13:45 - 14:00
Challenges of understanding complex signalling pathways, utilising data generated from high throughput screening
Selected oral communication - Nikole Waddell (Pfizer, United Kingdom)
14:00 - 14:30
Cancer and cellular information processing
Rune Linding (Technical University of Denmark, Denmark)
14:30 Close of meeting and departure

Signalling interactions involving intracellular calcium - part II

 

Chair:
Sandip Patel (before coffee) and Colin Taylor (after coffee) (University College London, United Kingdom) (University of Cambridge, United Kingdom)
Friday 10 June 2011
10:00 - 10:30
Signalling to and from IP3 receptors
Colin Taylor (University of Cambridge, United Kingdom)
10:30 - 10:45
IP3 receptors, store-operated Ca2+ entry and neuronal Ca2+ homeostasis in Drosophila.
Selected oral communication - Sumita Chakraborty (National Centre for Biological Sciences, India)
10:45 - 11:00
Development of chemical tools and drugs to reveal novel biology and new drug targets in the heart
Selected oral communication - Sridhar Vasudevan  (University of Oxford, United Kingdom)
11:00 - 11:30 Coffee/tea break

11:30 - 12:00
Coordination of calcium signalling by NAADP-gated two-pore channels
Sandip Patel (University College London, United Kingdom)
12:00 - 12:30
Calcium signalling at fertilization mediated by sperm PLC-zeta
Tony Lai (Cardiff University School of Medicine, United Kingdom)
12:30 - 13:30 Lunch

13:30 - 13:45
Assembly of NAADP-gated two-pore channels
Selected oral communication - Dev Churamani (University College London, United Kingdom)
13:45 - 14:00
A single EF-loop directs calcium sensitivity in phospholipase C-η2
Selected oral communication - Petra Popovics (University of St Andrews, United Kingdom)
14:00 - 14:30
Mitochondrial architecture and mobility in resistance arteries
John McCarron (University of Strathclyde, United Kingdom)
14:30 Close of meeting and departure

Future directions in signalling - part II

 

Chair:
Simon Morley (University of Sussex, United Kingdom)
Friday 10 June 2011
10:00 - 10:30
Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis
Chris Proud (University of Southampton, United Kingdom)
10:30 - 10:45
Scanning peptide array pinpoints novel docking domains for protein kinase D1, a novel kinase for the regulation of heat shock protein 20
Selected oral communication - Yuan Yan Sin (University of Glasgow, United Kingdom)
10:45 - 11:00
Inhibition of IL-6-stimulated STAT3 phosphorylation by AMP-activated protein kinase in vascular endothelial cells
Selected oral communication - Claire Rutherford (University of Glasgow, United Kingdom)
11:00 - 11:30 Coffee/tea break

11:30 - 12:00
How SUMO talks to ubiquitin
Ronald Hay (University of Dundee, United Kingdom)
12:00 - 12:30
DNA damage response signalling and how it influences double strand break repair
Penny Jeggo (University of Sussex, United Kingdom)
12:30 - 13:30 Lunch

13:30 - 13:45
Adhesion-dependent regulation of Skp-2 gene transcription and cell proliferation by Selenocysteine tRNA gene activating factor (STAF)
Selected oral communication - Mark Bond (University of Bristol, United Kingdom)
13:45 - 14:00
Specificity of protein histidine phosphatase for the three forms of phosphohistidine in histone H4 peptide analogues.
Selected oral communication - Paul Attwood (University of Western Australia)
14:00 - 14:30
Regulation of TGF-beta/Smad signaling
Caroline Hill (London Research Institute, United Kingdom)
14:30 Close of meeting and departure