Home
Membership
Get Involved
Conferences
Education
Public Affairs
Publications
Grants
Awards
About Us
Vacancies


Biometals 2002 3rd International Biometals Symposium

11—13 April 2002

King¿s College London, Franklin-Wilkins Building, Waterloo, London



Timetable

Thursday 11 April 2002Friday 12 April 2002Saturday 13 April 2002
10:30 - 18:00
Plenary Lecture

10:30 - 18:00
Metal Transport I

10:30 - 18:00
Metal Transport II

10:30 - 18:00
Intracellular Trafficking

10:30 - 18:00
Metal Toxicity and Therapeutic Intervention

10:30 - 18:00
Functional Genomics and Gene Regulation in Biometals Research

10:30 - 18:00
Metal Insertion into Proteins

09:00 - 15:45
Plenary Lecture

09:00 - 15:45
Metal Transport I

09:00 - 15:45
Metal Transport II

09:00 - 15:45
Intracellular Trafficking

09:00 - 15:45
Metal Toxicity and Therapeutic Intervention

09:00 - 15:45
Functional Genomics and Gene Regulation in Biometals Research

09:00 - 15:45
Metal Insertion into Proteins

09:00 - 17:00
Plenary Lecture

09:00 - 17:00
Metal Transport I

09:00 - 17:00
Metal Transport II

09:00 - 17:00
Intracellular Trafficking

09:00 - 17:00
Metal Toxicity and Therapeutic Intervention

09:00 - 17:00
Functional Genomics and Gene Regulation in Biometals Research

09:00 - 17:00
Metal Insertion into Proteins


Plenary Lecture

Thursday 11 April 2002
14:30 - 15:00
Role of molecular scaffolds in Fe-S cluster assembly
Dennis Dean (Blacksburg, VA, USA)
15:00 - 15:15
Sulfolobus aconitase, a regulator in iron metabolism?
Helge Uhrigshardt ( Leubeck, Germany)
15:15 - 15:45
Copper induced proteolysis of the CopZ copper chaperone of Enterococcus hirae
Marc Solioz (Berne, Switzerland)
15:45 - 16:15 Tea/coffee

16:15 - 16:45
Microbial siderophore mediated transport
Guenther Winkelmann (Tuebingen, Germany)
16:45 - 17:00
Siderophore production by Fusarium venenatum
Marilyn Wiebe (Aalborg, Denmark)
17:00 - 17:15
The cell biology of siderophore uptake in Saccharomyces cerevisiae protein Alr1
Caroline Philpott (National Institutes of Health, Bethesda, MD, USA)
17:15 - 17:30
The new mechanism for membrane iron transport in Pseudomonsa aeruginosa
Isabelle Schalk (ESBS, France)
17:30 - 17:45
Characterization of Mrs2p as the major Mg2+ transporter in mitochondria
Rudolf Schweyn (Vienna, Austria)
17:45 - 18:00
Transferrin-mediated iron acquisition by Neisseria meningitidis
Robert Evans (London, UK)
18:30 Reception at the Royal National Theatre

Friday 12 April 2002
09:00 - 09:30
Bipartite gating in the outer membrane transporter FecA
Dick van der Helm (Victoria, BC, Canada)
09:30 - 09:45
Investigations of iron uptake in Halobacterium salinarum
Dirk Hubmacher (Luebeck, Germany)
09:45 - 10:00
Purification and characterization of a Dps-homologous non-haem ferritin of the Archaeon Halobacterium salinarum
Sabine Reindel (Luebeck, Germany)
10:00 - 10:15
The role of membranous and N-terminal metal binding sites in the functioning of heavy metal ATPases
Nathalie Bal (CEA, Grenoble, France)
10:15 - 10:45
Mercury transport and resistance - new mechanisms for old determinants?
Nigel Brown (Birmingham, UK)
10:45 - 11:00
Mercury resistance determinants from the 'pre-antibiotic' era
Jon Hobman (Birmingham, UK)
11:00 - 11:30 Tea/coffee

14:00 - 14:30
Genetic dissection of intracellular iron metabolism in yeast : implications for human disease
Jerry Kaplan (Salt Lake City, UT, USA)
14:30 - 14:45
Two arabidopis COX17 homologues are oppositely regulated by copper
Henri Wintz (Berkeley, CA, USA)
14:45 - 15:00
Iron targeting to mitochondria in erythroid cells
Prem Ponka (McGill, Quebec, Canada)
15:00 - 15:15
Copper-dependent phosphorylation of the Wilson's disease protein
Scott Vanderwerf (Portland, OR, USA)
15:15 - 15:45
Evolutionary conservation of the metallome? Total metal content across divergent organisms
Nina Brown (Evanston, IL, USA)
15:45 - 17:45 Coffee/poster session

18:00
Walk to London Bridge alongside River Thames
19:00 Conference dinner - Guy's Tower, King's College London

Saturday 13 April 2002
09:00 - 09:30
The prion protein is a high affinity copper binding superoxide dismutase
David Brown (Bath, UK)
09:30 - 09:45
Can nitric oxide react with copper proteins in the brain?
Chris Cooper (Essex, UK)
09:45 - 10:00
Calcineurin phosphatase activity is modulated by redox processes at the enzyme binuclear Fe2+-Zn2+ catalytic centre
Dmitry Namgaladze (Konstanz, Germany)
10:00 - 10:15
Neurotoxicity of haemoglobin: oxidative stress in patients with subarachnoid haemorrhage
Brandon Reeder (Essex, UK)
10:15 - 10:30
Chomium VI induced cytoskeletal damage and cell death in isolated hepatocytes
Mekala Gunaratnam (Strathclyde, UK)
10:30 - 11:00 Tea/coffee

13:15 - 13:45
Molecular mechanisms of cellular zinc homeostasis in yeast
David Eide (Missouri, MO, USA)
13:45 - 14:00
Comparative analysis of arabidopsis gene expression profiles in response to copper, zinc and iron deficiencies
Henri Wintz (Berkeley, CA, USA)
14:00 - 14:15
Manganese sensing in the cyanobacterium Synechocystis 6803
Maitrayee Bhattacharyya-Pakrasi (St Louis, MO, USA)
14:15 - 14:30
The crystal structure of a Fur protein
Andrew Hemmings (East Anglia, UK)
14:30 - 14:45
c-myc represses the murine Nramp1 promoter
Holly Bowen (Southampton, UK)
14:45 - 15:00
Control of ferritin expression as a cellular strategy for modulating cell growth
Or Kakhlon (Jerusalem, Israel)
15:00 - 15:15
Identification of members of the Aspergillus nidulans SREA-regulon:genes involved in siderophore biosynthesis and utilization
Hubertus Haas (Innsbruck, Austria)
15:15 - 15:45 Tea/coffee

15:45 - 16:00
A novel role of the iron regulon in cobalt tolerance
Jochen Stadler (Vienna, Austria)
16:00 - 16:15
The bacterial iron response regulator responds to iron and haem localised at the site of haem biosynthesis
Mark O'Brian (New York, USA)
16:15 - 16:30
Human and murine 'iron chips' : new possibilities to understand iron regulatory networks in mouse models and patients
Martina Muckenthaler (Heidelberg, Germany)
16:30 - 17:00
Gene discovery in aid of plant nutrition, human health and environmental remediation
Mary Lou Guerinot (Hanover, NH, USA)
18:30
Flight on the London Eye

Morning

Chair:
Robert Hider (King's College London, UK)
Thursday 11 April 2002
10:30 - 10:35
Welcome Address
Robert Hider (King's College London, UK)
10:35 - 11:25
Iron limitation of biogeochemical cycles in the oceans
Paul Falkowski (Rutgers, NJ, USA)
11:25 - 11:45 Tea/coffee

11:45 - 12:15
Mercury pollution, microbial resistance, metabolic design and bioremediation
Kenneth Timmis (GPF National Research Centre for Biotechnology, Braunschwieg, Germany)
12:15 - 12:30
Molecular and atomic analysis of the uranium complexes formed by the three eco-types of Acidithiobacillus ferooxidans
Mohamed Merroun (Institute of Radiochemistry, Saxony, Germany)
12:30 - 12:45
A novel bioprocess for mercury removal
Ashraf Essa ( Birmingham, UK)
12:45 - 13:00
Exploring the role of free histidine as a chelator in nickel tolerance and hyperaccumulation in plants
Ute Kraemer (Max Planck Institute of Molecular Plant Physiology, Golm, Germany)
13:00 - 14:00 Lunch

14:00 - 14:30
Metal insertion into NiFe-hydrogenases
August Böck (Inst für Genetik und Mikrobiologie, München, Germany)

Bioremediation


Metal Insertion into Proteins

Thursday 11 April 2002
10:30 - 10:35
Welcome Address
Robert Hider (King's College London, UK)
10:35 - 11:25
Iron limitation of biogeochemical cycles in the oceans
Paul Falkowski (Rutgers, NJ, USA)
11:25 - 11:45 Tea/coffee

11:45 - 12:15
Mercury pollution, microbial resistance, metabolic design and bioremediation
Kenneth Timmis (GPF National Research Centre for Biotechnology, Braunschwieg, Germany)
Friday 12 April 2002
09:00 - 09:30
Bipartite gating in the outer membrane transporter FecA
Dick van der Helm (Victoria, BC, Canada)
09:30 - 09:45
Investigations of iron uptake in Halobacterium salinarum
Dirk Hubmacher (Luebeck, Germany)
09:45 - 10:00
Purification and characterization of a Dps-homologous non-haem ferritin of the Archaeon Halobacterium salinarum
Sabine Reindel (Luebeck, Germany)
10:00 - 10:15
The role of membranous and N-terminal metal binding sites in the functioning of heavy metal ATPases
Nathalie Bal (CEA, Grenoble, France)
10:15 - 10:45
Mercury transport and resistance - new mechanisms for old determinants?
Nigel Brown (Birmingham, UK)
10:45 - 11:00
Mercury resistance determinants from the 'pre-antibiotic' era
Jon Hobman (Birmingham, UK)
11:00 - 11:30 Tea/coffee

14:00 - 14:30
Genetic dissection of intracellular iron metabolism in yeast : implications for human disease
Jerry Kaplan (Salt Lake City, UT, USA)
14:30 - 14:45
Two arabidopis COX17 homologues are oppositely regulated by copper
Henri Wintz (Berkeley, CA, USA)
14:45 - 15:00
Iron targeting to mitochondria in erythroid cells
Prem Ponka (McGill, Quebec, Canada)
15:00 - 15:15
Copper-dependent phosphorylation of the Wilson's disease protein
Scott Vanderwerf (Portland, OR, USA)
15:15 - 15:45
Evolutionary conservation of the metallome? Total metal content across divergent organisms
Nina Brown (Evanston, IL, USA)
15:45 - 17:45 Coffee/poster session

18:00
Walk to London Bridge alongside River Thames
19:00 Conference dinner - Guy's Tower, King's College London

Saturday 13 April 2002
09:00 - 09:30
The prion protein is a high affinity copper binding superoxide dismutase
David Brown (Bath, UK)
09:30 - 09:45
Can nitric oxide react with copper proteins in the brain?
Chris Cooper (Essex, UK)
09:45 - 10:00
Calcineurin phosphatase activity is modulated by redox processes at the enzyme binuclear Fe2+-Zn2+ catalytic centre
Dmitry Namgaladze (Konstanz, Germany)
10:00 - 10:15
Neurotoxicity of haemoglobin: oxidative stress in patients with subarachnoid haemorrhage
Brandon Reeder (Essex, UK)
10:15 - 10:30
Chomium VI induced cytoskeletal damage and cell death in isolated hepatocytes
Mekala Gunaratnam (Strathclyde, UK)
10:30 - 11:00 Tea/coffee

13:15 - 13:45
Molecular mechanisms of cellular zinc homeostasis in yeast
David Eide (Missouri, MO, USA)
13:45 - 14:00
Comparative analysis of arabidopsis gene expression profiles in response to copper, zinc and iron deficiencies
Henri Wintz (Berkeley, CA, USA)
14:00 - 14:15
Manganese sensing in the cyanobacterium Synechocystis 6803
Maitrayee Bhattacharyya-Pakrasi (St Louis, MO, USA)
14:15 - 14:30
The crystal structure of a Fur protein
Andrew Hemmings (East Anglia, UK)
14:30 - 14:45
c-myc represses the murine Nramp1 promoter
Holly Bowen (Southampton, UK)
14:45 - 15:00
Control of ferritin expression as a cellular strategy for modulating cell growth
Or Kakhlon (Jerusalem, Israel)
15:00 - 15:15
Identification of members of the Aspergillus nidulans SREA-regulon:genes involved in siderophore biosynthesis and utilization
Hubertus Haas (Innsbruck, Austria)
15:15 - 15:45 Tea/coffee

15:45 - 16:00
A novel role of the iron regulon in cobalt tolerance
Jochen Stadler (Vienna, Austria)
16:00 - 16:15
The bacterial iron response regulator responds to iron and haem localised at the site of haem biosynthesis
Mark O'Brian (New York, USA)
16:15 - 16:30
Human and murine 'iron chips' : new possibilities to understand iron regulatory networks in mouse models and patients
Martina Muckenthaler (Heidelberg, Germany)
16:30 - 17:00
Gene discovery in aid of plant nutrition, human health and environmental remediation
Mary Lou Guerinot (Hanover, NH, USA)
18:30
Flight on the London Eye

Afternoon

Chair:
Richard Cammack (King's College London, UK)
Thursday 11 April 2002
12:15 - 12:30
Molecular and atomic analysis of the uranium complexes formed by the three eco-types of Acidithiobacillus ferooxidans
Mohamed Merroun (Institute of Radiochemistry, Saxony, Germany)
12:30 - 12:45
A novel bioprocess for mercury removal
Ashraf Essa ( Birmingham, UK)
12:45 - 13:00
Exploring the role of free histidine as a chelator in nickel tolerance and hyperaccumulation in plants
Ute Kraemer (Max Planck Institute of Molecular Plant Physiology, Golm, Germany)
13:00 - 14:00 Lunch

14:00 - 14:30
Metal insertion into NiFe-hydrogenases
August Böck (Inst für Genetik und Mikrobiologie, München, Germany)
14:30 - 15:00
Role of molecular scaffolds in Fe-S cluster assembly
Dennis Dean (Blacksburg, VA, USA)
15:00 - 15:15
Sulfolobus aconitase, a regulator in iron metabolism?
Helge Uhrigshardt ( Leubeck, Germany)
15:15 - 15:45
Copper induced proteolysis of the CopZ copper chaperone of Enterococcus hirae
Marc Solioz (Berne, Switzerland)
15:45 - 16:15 Tea/coffee

16:15 - 16:45
Microbial siderophore mediated transport
Guenther Winkelmann (Tuebingen, Germany)
16:45 - 17:00
Siderophore production by Fusarium venenatum
Marilyn Wiebe (Aalborg, Denmark)
17:00 - 17:15
The cell biology of siderophore uptake in Saccharomyces cerevisiae protein Alr1
Caroline Philpott (National Institutes of Health, Bethesda, MD, USA)
17:15 - 17:30
The new mechanism for membrane iron transport in Pseudomonsa aeruginosa
Isabelle Schalk (ESBS, France)
17:30 - 17:45
Characterization of Mrs2p as the major Mg2+ transporter in mitochondria
Rudolf Schweyn (Vienna, Austria)
17:45 - 18:00
Transferrin-mediated iron acquisition by Neisseria meningitidis
Robert Evans (London, UK)
18:30 Reception at the Royal National Theatre

Metal Transport I

Thursday 11 April 2002
10:30 - 10:35
Welcome Address
Robert Hider (King's College London, UK)
10:35 - 11:25
Iron limitation of biogeochemical cycles in the oceans
Paul Falkowski (Rutgers, NJ, USA)
11:25 - 11:45 Tea/coffee

11:45 - 12:15
Mercury pollution, microbial resistance, metabolic design and bioremediation
Kenneth Timmis (GPF National Research Centre for Biotechnology, Braunschwieg, Germany)
Friday 12 April 2002
09:00 - 09:30
Bipartite gating in the outer membrane transporter FecA
Dick van der Helm (Victoria, BC, Canada)
09:30 - 09:45
Investigations of iron uptake in Halobacterium salinarum
Dirk Hubmacher (Luebeck, Germany)
09:45 - 10:00
Purification and characterization of a Dps-homologous non-haem ferritin of the Archaeon Halobacterium salinarum
Sabine Reindel (Luebeck, Germany)
10:00 - 10:15
The role of membranous and N-terminal metal binding sites in the functioning of heavy metal ATPases
Nathalie Bal (CEA, Grenoble, France)
10:15 - 10:45
Mercury transport and resistance - new mechanisms for old determinants?
Nigel Brown (Birmingham, UK)
10:45 - 11:00
Mercury resistance determinants from the 'pre-antibiotic' era
Jon Hobman (Birmingham, UK)
11:00 - 11:30 Tea/coffee

14:00 - 14:30
Genetic dissection of intracellular iron metabolism in yeast : implications for human disease
Jerry Kaplan (Salt Lake City, UT, USA)
14:30 - 14:45
Two arabidopis COX17 homologues are oppositely regulated by copper
Henri Wintz (Berkeley, CA, USA)
14:45 - 15:00
Iron targeting to mitochondria in erythroid cells
Prem Ponka (McGill, Quebec, Canada)
15:00 - 15:15
Copper-dependent phosphorylation of the Wilson's disease protein
Scott Vanderwerf (Portland, OR, USA)
15:15 - 15:45
Evolutionary conservation of the metallome? Total metal content across divergent organisms
Nina Brown (Evanston, IL, USA)
15:45 - 17:45 Coffee/poster session

18:00
Walk to London Bridge alongside River Thames
19:00 Conference dinner - Guy's Tower, King's College London

Saturday 13 April 2002
09:00 - 09:30
The prion protein is a high affinity copper binding superoxide dismutase
David Brown (Bath, UK)
09:30 - 09:45
Can nitric oxide react with copper proteins in the brain?
Chris Cooper (Essex, UK)
09:45 - 10:00
Calcineurin phosphatase activity is modulated by redox processes at the enzyme binuclear Fe2+-Zn2+ catalytic centre
Dmitry Namgaladze (Konstanz, Germany)
10:00 - 10:15
Neurotoxicity of haemoglobin: oxidative stress in patients with subarachnoid haemorrhage
Brandon Reeder (Essex, UK)
10:15 - 10:30
Chomium VI induced cytoskeletal damage and cell death in isolated hepatocytes
Mekala Gunaratnam (Strathclyde, UK)
10:30 - 11:00 Tea/coffee

13:15 - 13:45
Molecular mechanisms of cellular zinc homeostasis in yeast
David Eide (Missouri, MO, USA)
13:45 - 14:00
Comparative analysis of arabidopsis gene expression profiles in response to copper, zinc and iron deficiencies
Henri Wintz (Berkeley, CA, USA)
14:00 - 14:15
Manganese sensing in the cyanobacterium Synechocystis 6803
Maitrayee Bhattacharyya-Pakrasi (St Louis, MO, USA)
14:15 - 14:30
The crystal structure of a Fur protein
Andrew Hemmings (East Anglia, UK)
14:30 - 14:45
c-myc represses the murine Nramp1 promoter
Holly Bowen (Southampton, UK)
14:45 - 15:00
Control of ferritin expression as a cellular strategy for modulating cell growth
Or Kakhlon (Jerusalem, Israel)
15:00 - 15:15
Identification of members of the Aspergillus nidulans SREA-regulon:genes involved in siderophore biosynthesis and utilization
Hubertus Haas (Innsbruck, Austria)
15:15 - 15:45 Tea/coffee

15:45 - 16:00
A novel role of the iron regulon in cobalt tolerance
Jochen Stadler (Vienna, Austria)
16:00 - 16:15
The bacterial iron response regulator responds to iron and haem localised at the site of haem biosynthesis
Mark O'Brian (New York, USA)
16:15 - 16:30
Human and murine 'iron chips' : new possibilities to understand iron regulatory networks in mouse models and patients
Martina Muckenthaler (Heidelberg, Germany)
16:30 - 17:00
Gene discovery in aid of plant nutrition, human health and environmental remediation
Mary Lou Guerinot (Hanover, NH, USA)
18:30
Flight on the London Eye

Afternoon

Chair:
Mohamed Abdallah (CNRS, Illkrich, France)
Thursday 11 April 2002
12:15 - 12:30
Molecular and atomic analysis of the uranium complexes formed by the three eco-types of Acidithiobacillus ferooxidans
Mohamed Merroun (Institute of Radiochemistry, Saxony, Germany)
12:30 - 12:45
A novel bioprocess for mercury removal
Ashraf Essa ( Birmingham, UK)
12:45 - 13:00
Exploring the role of free histidine as a chelator in nickel tolerance and hyperaccumulation in plants
Ute Kraemer (Max Planck Institute of Molecular Plant Physiology, Golm, Germany)
13:00 - 14:00 Lunch

14:00 - 14:30
Metal insertion into NiFe-hydrogenases
August Böck (Inst für Genetik und Mikrobiologie, München, Germany)
14:30 - 15:00
Role of molecular scaffolds in Fe-S cluster assembly
Dennis Dean (Blacksburg, VA, USA)
15:00 - 15:15
Sulfolobus aconitase, a regulator in iron metabolism?
Helge Uhrigshardt ( Leubeck, Germany)
15:15 - 15:45
Copper induced proteolysis of the CopZ copper chaperone of Enterococcus hirae
Marc Solioz (Berne, Switzerland)
15:45 - 16:15 Tea/coffee

16:15 - 16:45
Microbial siderophore mediated transport
Guenther Winkelmann (Tuebingen, Germany)
16:45 - 17:00
Siderophore production by Fusarium venenatum
Marilyn Wiebe (Aalborg, Denmark)
17:00 - 17:15
The cell biology of siderophore uptake in Saccharomyces cerevisiae protein Alr1
Caroline Philpott (National Institutes of Health, Bethesda, MD, USA)
17:15 - 17:30
The new mechanism for membrane iron transport in Pseudomonsa aeruginosa
Isabelle Schalk (ESBS, France)
17:30 - 17:45
Characterization of Mrs2p as the major Mg2+ transporter in mitochondria
Rudolf Schweyn (Vienna, Austria)
17:45 - 18:00
Transferrin-mediated iron acquisition by Neisseria meningitidis
Robert Evans (London, UK)
18:30 Reception at the Royal National Theatre

Metal Transport II

Thursday 11 April 2002
10:30 - 10:35
Welcome Address
Robert Hider (King's College London, UK)
10:35 - 11:25
Iron limitation of biogeochemical cycles in the oceans
Paul Falkowski (Rutgers, NJ, USA)
11:25 - 11:45 Tea/coffee

11:45 - 12:15
Mercury pollution, microbial resistance, metabolic design and bioremediation
Kenneth Timmis (GPF National Research Centre for Biotechnology, Braunschwieg, Germany)
12:15 - 12:30
Molecular and atomic analysis of the uranium complexes formed by the three eco-types of Acidithiobacillus ferooxidans
Mohamed Merroun (Institute of Radiochemistry, Saxony, Germany)
12:30 - 12:45
A novel bioprocess for mercury removal
Ashraf Essa ( Birmingham, UK)
12:45 - 13:00
Exploring the role of free histidine as a chelator in nickel tolerance and hyperaccumulation in plants
Ute Kraemer (Max Planck Institute of Molecular Plant Physiology, Golm, Germany)
13:00 - 14:00 Lunch

14:00 - 14:30
Metal insertion into NiFe-hydrogenases
August Böck (Inst für Genetik und Mikrobiologie, München, Germany)
14:30 - 15:00
Role of molecular scaffolds in Fe-S cluster assembly
Dennis Dean (Blacksburg, VA, USA)
15:00 - 15:15
Sulfolobus aconitase, a regulator in iron metabolism?
Helge Uhrigshardt ( Leubeck, Germany)
15:15 - 15:45
Copper induced proteolysis of the CopZ copper chaperone of Enterococcus hirae
Marc Solioz (Berne, Switzerland)
15:45 - 16:15 Tea/coffee

16:15 - 16:45
Microbial siderophore mediated transport
Guenther Winkelmann (Tuebingen, Germany)
16:45 - 17:00
Siderophore production by Fusarium venenatum
Marilyn Wiebe (Aalborg, Denmark)
17:00 - 17:15
The cell biology of siderophore uptake in Saccharomyces cerevisiae protein Alr1
Caroline Philpott (National Institutes of Health, Bethesda, MD, USA)
17:15 - 17:30
The new mechanism for membrane iron transport in Pseudomonsa aeruginosa
Isabelle Schalk (ESBS, France)
17:30 - 17:45
Characterization of Mrs2p as the major Mg2+ transporter in mitochondria
Rudolf Schweyn (Vienna, Austria)
17:45 - 18:00
Transferrin-mediated iron acquisition by Neisseria meningitidis
Robert Evans (London, UK)
18:30 Reception at the Royal National Theatre

Friday 12 April 2002
14:30 - 14:45
Two arabidopis COX17 homologues are oppositely regulated by copper
Henri Wintz (Berkeley, CA, USA)
14:45 - 15:00
Iron targeting to mitochondria in erythroid cells
Prem Ponka (McGill, Quebec, Canada)
15:00 - 15:15
Copper-dependent phosphorylation of the Wilson's disease protein
Scott Vanderwerf (Portland, OR, USA)
15:15 - 15:45
Evolutionary conservation of the metallome? Total metal content across divergent organisms
Nina Brown (Evanston, IL, USA)
15:45 - 17:45 Coffee/poster session

18:00
Walk to London Bridge alongside River Thames
19:00 Conference dinner - Guy's Tower, King's College London

Saturday 13 April 2002
09:00 - 09:30
The prion protein is a high affinity copper binding superoxide dismutase
David Brown (Bath, UK)
09:30 - 09:45
Can nitric oxide react with copper proteins in the brain?
Chris Cooper (Essex, UK)
09:45 - 10:00
Calcineurin phosphatase activity is modulated by redox processes at the enzyme binuclear Fe2+-Zn2+ catalytic centre
Dmitry Namgaladze (Konstanz, Germany)
10:00 - 10:15
Neurotoxicity of haemoglobin: oxidative stress in patients with subarachnoid haemorrhage
Brandon Reeder (Essex, UK)
10:15 - 10:30
Chomium VI induced cytoskeletal damage and cell death in isolated hepatocytes
Mekala Gunaratnam (Strathclyde, UK)
10:30 - 11:00 Tea/coffee

13:15 - 13:45
Molecular mechanisms of cellular zinc homeostasis in yeast
David Eide (Missouri, MO, USA)
13:45 - 14:00
Comparative analysis of arabidopsis gene expression profiles in response to copper, zinc and iron deficiencies
Henri Wintz (Berkeley, CA, USA)
14:00 - 14:15
Manganese sensing in the cyanobacterium Synechocystis 6803
Maitrayee Bhattacharyya-Pakrasi (St Louis, MO, USA)
14:15 - 14:30
The crystal structure of a Fur protein
Andrew Hemmings (East Anglia, UK)
14:30 - 14:45
c-myc represses the murine Nramp1 promoter
Holly Bowen (Southampton, UK)
14:45 - 15:00
Control of ferritin expression as a cellular strategy for modulating cell growth
Or Kakhlon (Jerusalem, Israel)
15:00 - 15:15
Identification of members of the Aspergillus nidulans SREA-regulon:genes involved in siderophore biosynthesis and utilization
Hubertus Haas (Innsbruck, Austria)
15:15 - 15:45 Tea/coffee

15:45 - 16:00
A novel role of the iron regulon in cobalt tolerance
Jochen Stadler (Vienna, Austria)
16:00 - 16:15
The bacterial iron response regulator responds to iron and haem localised at the site of haem biosynthesis
Mark O'Brian (New York, USA)
16:15 - 16:30
Human and murine 'iron chips' : new possibilities to understand iron regulatory networks in mouse models and patients
Martina Muckenthaler (Heidelberg, Germany)
16:30 - 17:00
Gene discovery in aid of plant nutrition, human health and environmental remediation
Mary Lou Guerinot (Hanover, NH, USA)
18:30
Flight on the London Eye

Morning

Chair:
Simon Andrews (Reading, UK)
Friday 12 April 2002
09:00 - 09:30
Bipartite gating in the outer membrane transporter FecA
Dick van der Helm (Victoria, BC, Canada)
09:30 - 09:45
Investigations of iron uptake in Halobacterium salinarum
Dirk Hubmacher (Luebeck, Germany)
09:45 - 10:00
Purification and characterization of a Dps-homologous non-haem ferritin of the Archaeon Halobacterium salinarum
Sabine Reindel (Luebeck, Germany)
10:00 - 10:15
The role of membranous and N-terminal metal binding sites in the functioning of heavy metal ATPases
Nathalie Bal (CEA, Grenoble, France)
10:15 - 10:45
Mercury transport and resistance - new mechanisms for old determinants?
Nigel Brown (Birmingham, UK)
10:45 - 11:00
Mercury resistance determinants from the 'pre-antibiotic' era
Jon Hobman (Birmingham, UK)
11:00 - 11:30 Tea/coffee

14:00 - 14:30
Genetic dissection of intracellular iron metabolism in yeast : implications for human disease
Jerry Kaplan (Salt Lake City, UT, USA)

Intracellular Trafficking

Thursday 11 April 2002
10:30 - 10:35
Welcome Address
Robert Hider (King's College London, UK)
10:35 - 11:25
Iron limitation of biogeochemical cycles in the oceans
Paul Falkowski (Rutgers, NJ, USA)
11:25 - 11:45 Tea/coffee

11:45 - 12:15
Mercury pollution, microbial resistance, metabolic design and bioremediation
Kenneth Timmis (GPF National Research Centre for Biotechnology, Braunschwieg, Germany)
12:15 - 12:30
Molecular and atomic analysis of the uranium complexes formed by the three eco-types of Acidithiobacillus ferooxidans
Mohamed Merroun (Institute of Radiochemistry, Saxony, Germany)
12:30 - 12:45
A novel bioprocess for mercury removal
Ashraf Essa ( Birmingham, UK)
12:45 - 13:00
Exploring the role of free histidine as a chelator in nickel tolerance and hyperaccumulation in plants
Ute Kraemer (Max Planck Institute of Molecular Plant Physiology, Golm, Germany)
13:00 - 14:00 Lunch

14:00 - 14:30
Metal insertion into NiFe-hydrogenases
August Böck (Inst für Genetik und Mikrobiologie, München, Germany)
14:30 - 15:00
Role of molecular scaffolds in Fe-S cluster assembly
Dennis Dean (Blacksburg, VA, USA)
15:00 - 15:15
Sulfolobus aconitase, a regulator in iron metabolism?
Helge Uhrigshardt ( Leubeck, Germany)
15:15 - 15:45
Copper induced proteolysis of the CopZ copper chaperone of Enterococcus hirae
Marc Solioz (Berne, Switzerland)
15:45 - 16:15 Tea/coffee

16:15 - 16:45
Microbial siderophore mediated transport
Guenther Winkelmann (Tuebingen, Germany)
16:45 - 17:00
Siderophore production by Fusarium venenatum
Marilyn Wiebe (Aalborg, Denmark)
17:00 - 17:15
The cell biology of siderophore uptake in Saccharomyces cerevisiae protein Alr1
Caroline Philpott (National Institutes of Health, Bethesda, MD, USA)
17:15 - 17:30
The new mechanism for membrane iron transport in Pseudomonsa aeruginosa
Isabelle Schalk (ESBS, France)
17:30 - 17:45
Characterization of Mrs2p as the major Mg2+ transporter in mitochondria
Rudolf Schweyn (Vienna, Austria)
17:45 - 18:00
Transferrin-mediated iron acquisition by Neisseria meningitidis
Robert Evans (London, UK)
18:30 Reception at the Royal National Theatre

Friday 12 April 2002
09:00 - 09:30
Bipartite gating in the outer membrane transporter FecA
Dick van der Helm (Victoria, BC, Canada)
09:30 - 09:45
Investigations of iron uptake in Halobacterium salinarum
Dirk Hubmacher (Luebeck, Germany)
09:45 - 10:00
Purification and characterization of a Dps-homologous non-haem ferritin of the Archaeon Halobacterium salinarum
Sabine Reindel (Luebeck, Germany)
10:00 - 10:15
The role of membranous and N-terminal metal binding sites in the functioning of heavy metal ATPases
Nathalie Bal (CEA, Grenoble, France)
10:15 - 10:45
Mercury transport and resistance - new mechanisms for old determinants?
Nigel Brown (Birmingham, UK)
10:45 - 11:00
Mercury resistance determinants from the 'pre-antibiotic' era
Jon Hobman (Birmingham, UK)
11:00 - 11:30 Tea/coffee

Saturday 13 April 2002
09:00 - 09:30
The prion protein is a high affinity copper binding superoxide dismutase
David Brown (Bath, UK)
09:30 - 09:45
Can nitric oxide react with copper proteins in the brain?
Chris Cooper (Essex, UK)
09:45 - 10:00
Calcineurin phosphatase activity is modulated by redox processes at the enzyme binuclear Fe2+-Zn2+ catalytic centre
Dmitry Namgaladze (Konstanz, Germany)
10:00 - 10:15
Neurotoxicity of haemoglobin: oxidative stress in patients with subarachnoid haemorrhage
Brandon Reeder (Essex, UK)
10:15 - 10:30
Chomium VI induced cytoskeletal damage and cell death in isolated hepatocytes
Mekala Gunaratnam (Strathclyde, UK)
10:30 - 11:00 Tea/coffee

13:15 - 13:45
Molecular mechanisms of cellular zinc homeostasis in yeast
David Eide (Missouri, MO, USA)
13:45 - 14:00
Comparative analysis of arabidopsis gene expression profiles in response to copper, zinc and iron deficiencies
Henri Wintz (Berkeley, CA, USA)
14:00 - 14:15
Manganese sensing in the cyanobacterium Synechocystis 6803
Maitrayee Bhattacharyya-Pakrasi (St Louis, MO, USA)
14:15 - 14:30
The crystal structure of a Fur protein
Andrew Hemmings (East Anglia, UK)
14:30 - 14:45
c-myc represses the murine Nramp1 promoter
Holly Bowen (Southampton, UK)
14:45 - 15:00
Control of ferritin expression as a cellular strategy for modulating cell growth
Or Kakhlon (Jerusalem, Israel)
15:00 - 15:15
Identification of members of the Aspergillus nidulans SREA-regulon:genes involved in siderophore biosynthesis and utilization
Hubertus Haas (Innsbruck, Austria)
15:15 - 15:45 Tea/coffee

15:45 - 16:00
A novel role of the iron regulon in cobalt tolerance
Jochen Stadler (Vienna, Austria)
16:00 - 16:15
The bacterial iron response regulator responds to iron and haem localised at the site of haem biosynthesis
Mark O'Brian (New York, USA)
16:15 - 16:30
Human and murine 'iron chips' : new possibilities to understand iron regulatory networks in mouse models and patients
Martina Muckenthaler (Heidelberg, Germany)
16:30 - 17:00
Gene discovery in aid of plant nutrition, human health and environmental remediation
Mary Lou Guerinot (Hanover, NH, USA)
18:30
Flight on the London Eye

Afternoon

Chair:
Kaila Srai (London, UK)
Friday 12 April 2002
14:00 - 14:30
Genetic dissection of intracellular iron metabolism in yeast : implications for human disease
Jerry Kaplan (Salt Lake City, UT, USA)
14:30 - 14:45
Two arabidopis COX17 homologues are oppositely regulated by copper
Henri Wintz (Berkeley, CA, USA)
14:45 - 15:00
Iron targeting to mitochondria in erythroid cells
Prem Ponka (McGill, Quebec, Canada)
15:00 - 15:15
Copper-dependent phosphorylation of the Wilson's disease protein
Scott Vanderwerf (Portland, OR, USA)
15:15 - 15:45
Evolutionary conservation of the metallome? Total metal content across divergent organisms
Nina Brown (Evanston, IL, USA)
15:45 - 17:45 Coffee/poster session

18:00
Walk to London Bridge alongside River Thames
19:00 Conference dinner - Guy's Tower, King's College London

Metal Toxicity and Therapeutic Intervention

Thursday 11 April 2002
10:30 - 10:35
Welcome Address
Robert Hider (King's College London, UK)
10:35 - 11:25
Iron limitation of biogeochemical cycles in the oceans
Paul Falkowski (Rutgers, NJ, USA)
11:25 - 11:45 Tea/coffee

11:45 - 12:15
Mercury pollution, microbial resistance, metabolic design and bioremediation
Kenneth Timmis (GPF National Research Centre for Biotechnology, Braunschwieg, Germany)
12:15 - 12:30
Molecular and atomic analysis of the uranium complexes formed by the three eco-types of Acidithiobacillus ferooxidans
Mohamed Merroun (Institute of Radiochemistry, Saxony, Germany)
12:30 - 12:45
A novel bioprocess for mercury removal
Ashraf Essa ( Birmingham, UK)
12:45 - 13:00
Exploring the role of free histidine as a chelator in nickel tolerance and hyperaccumulation in plants
Ute Kraemer (Max Planck Institute of Molecular Plant Physiology, Golm, Germany)
13:00 - 14:00 Lunch

14:00 - 14:30
Metal insertion into NiFe-hydrogenases
August Böck (Inst für Genetik und Mikrobiologie, München, Germany)
14:30 - 15:00
Role of molecular scaffolds in Fe-S cluster assembly
Dennis Dean (Blacksburg, VA, USA)
15:00 - 15:15
Sulfolobus aconitase, a regulator in iron metabolism?
Helge Uhrigshardt ( Leubeck, Germany)
15:15 - 15:45
Copper induced proteolysis of the CopZ copper chaperone of Enterococcus hirae
Marc Solioz (Berne, Switzerland)
15:45 - 16:15 Tea/coffee

16:15 - 16:45
Microbial siderophore mediated transport
Guenther Winkelmann (Tuebingen, Germany)
16:45 - 17:00
Siderophore production by Fusarium venenatum
Marilyn Wiebe (Aalborg, Denmark)
17:00 - 17:15
The cell biology of siderophore uptake in Saccharomyces cerevisiae protein Alr1
Caroline Philpott (National Institutes of Health, Bethesda, MD, USA)
17:15 - 17:30
The new mechanism for membrane iron transport in Pseudomonsa aeruginosa
Isabelle Schalk (ESBS, France)
17:30 - 17:45
Characterization of Mrs2p as the major Mg2+ transporter in mitochondria
Rudolf Schweyn (Vienna, Austria)
17:45 - 18:00
Transferrin-mediated iron acquisition by Neisseria meningitidis
Robert Evans (London, UK)
18:30 Reception at the Royal National Theatre

Friday 12 April 2002
09:00 - 09:30
Bipartite gating in the outer membrane transporter FecA
Dick van der Helm (Victoria, BC, Canada)
09:30 - 09:45
Investigations of iron uptake in Halobacterium salinarum
Dirk Hubmacher (Luebeck, Germany)
09:45 - 10:00
Purification and characterization of a Dps-homologous non-haem ferritin of the Archaeon Halobacterium salinarum
Sabine Reindel (Luebeck, Germany)
10:00 - 10:15
The role of membranous and N-terminal metal binding sites in the functioning of heavy metal ATPases
Nathalie Bal (CEA, Grenoble, France)
10:15 - 10:45
Mercury transport and resistance - new mechanisms for old determinants?
Nigel Brown (Birmingham, UK)
10:45 - 11:00
Mercury resistance determinants from the 'pre-antibiotic' era
Jon Hobman (Birmingham, UK)
11:00 - 11:30 Tea/coffee

14:00 - 14:30
Genetic dissection of intracellular iron metabolism in yeast : implications for human disease
Jerry Kaplan (Salt Lake City, UT, USA)
14:30 - 14:45
Two arabidopis COX17 homologues are oppositely regulated by copper
Henri Wintz (Berkeley, CA, USA)
14:45 - 15:00
Iron targeting to mitochondria in erythroid cells
Prem Ponka (McGill, Quebec, Canada)
15:00 - 15:15
Copper-dependent phosphorylation of the Wilson's disease protein
Scott Vanderwerf (Portland, OR, USA)
15:15 - 15:45
Evolutionary conservation of the metallome? Total metal content across divergent organisms
Nina Brown (Evanston, IL, USA)
15:45 - 17:45 Coffee/poster session

18:00
Walk to London Bridge alongside River Thames
19:00 Conference dinner - Guy's Tower, King's College London

Saturday 13 April 2002
14:15 - 14:30
The crystal structure of a Fur protein
Andrew Hemmings (East Anglia, UK)
14:30 - 14:45
c-myc represses the murine Nramp1 promoter
Holly Bowen (Southampton, UK)
14:45 - 15:00
Control of ferritin expression as a cellular strategy for modulating cell growth
Or Kakhlon (Jerusalem, Israel)
15:00 - 15:15
Identification of members of the Aspergillus nidulans SREA-regulon:genes involved in siderophore biosynthesis and utilization
Hubertus Haas (Innsbruck, Austria)
15:15 - 15:45 Tea/coffee

15:45 - 16:00
A novel role of the iron regulon in cobalt tolerance
Jochen Stadler (Vienna, Austria)
16:00 - 16:15