Organizers:
Robin Irvine (University of Cambridge, UK)
Pete Cullen (University of Bristol, UK)
Phil Godfrey Memorial Fund
Special Events
Phosphoinositide kinases and human disease
Lew Cantley (Harvard University, USA) (Harvard University, USA)
Timetable
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PtdIns(3,4,5)P3 signalling
Chair:
Peter Downes (University of Dundee, UK)
Redox regulation of inositol lipid signalling
Selected oral communication - Peter Downes (University of Dundee, UK)
Spatially encoded PKC signals
Peter Parker (Cancer Research UK)
Regulation of endocytic receptor down-regulation by phosphoinositides
Harald Stenmark (Norwegian Radium Hospital, Norway)
Phosphatidylinositol 3,5-bisphosphate, the ¿newest¿ PtdInsP2 isomer: metabolism and multiple functions
Bob Michell (University of Birmingham, UK)
ArPIKfyve-PIKfyve-PtdIns 3,5-P2 axis in hyperosmotic- and insulin-regulated glucose transport in 3T3-L1 adipocytes
Selected oral communication - Assia Shisheva (Wayne State University School of Medicine, USA)
Phosphoinositide signalling at the neuronal synapse
Pietro De Camilli (Yale University, USA)
Molecular mechanisms for spatial PIP2 generation
Richard Anderson (University of Wisconsin-Madison, USA)
Investigating the roles of class II phosphoinositide 3-kinases
Selected oral communication - Michael Fry (University of Reading, UK)
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Other 3-phosphorylated lipids
10:30 - 11:00 Coffee/tea break
S. cerevisiae AP-1 complex is required for Fab1p-dependent protein sorting to the vacuole lumen
Selected oral communication - John Phelan (University College London, UK)
Regulatory interactions between myotubularin PI 3-phosphatases and inactive pseudophosphatases.
Selected oral communication - Fred Robinson (University of California San Diego, USA)
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PIP kinases
16:00 - 18:00 Poster session
Role of class II phosphoinositide 3-kinases in cell signalling
Selected oral communication - Tania Maffucci (University College London, UK)
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PtdIns(4,5)P2 functions and tools
10:30 - 11:00 Coffee/tea break
Role of PIP kinases in Drosophila phosphoinositide signalling
Selected oral communication - Deepti Trivedi (The Babraham Institute, UK)
Nuclear inositide signalling: role of PLC beta1 in erythroleukemia cells
Selected oral communication - Lucio Cocco (University of Bologna, Italy)
Co-incidence detection in phosphoinositide signalling
Harvey McMahon (MRC-LMB, UK)
Molecular mechanisms of phosphoinositide 3-kinase alpha regulation and oncogenesis
Roger Williams (MRC-LMB, Cambridge, UK)
Gb residues relevant for interaction and stimulation of phosphoinositide 3-kinase g (PI3Kg) enzymatic activities
Selected oral communication - Aliaksei Shymanets (University of Duesseldorf, Germany)
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Structural Aspects
16:00 - 18:00 Poster session
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Inositol phosphates
10:30 - 11:00 Coffee/tea break
Inositol phosphate metabolism and its role in cell motility and lithium sensitivity in Dictyostelium discoideum
Selected oral communication - Jason King (Cardiff University, UK)
The complexation and precipitation behaviour of myo-inositol hexakisphosphate in the presence of multivalent cations
Selected oral communication - Alvaro Diaz (UDELAR, Uruguay)
16:00 - 18:00 Poster session
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Pyro-phosphorylated inositol phosphates
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Enzymes
Phosphorylation of proteins by inositol pyrophosphates
Selected oral communication - Rashna Bhandari (Johns Hopkins University, USA)
Detection of a trace amount of phosphoinositides by phosphoinositide-binding domains
Tadeomi Takenawa (University of Tokyo, Japan)
10:30 - 11:00 Coffee/tea break
Breakdown of plasma membrane PtdIns(4,5)P2 is required for mast cell exocytosis
Selected oral communication - Gerry Hammond (Cancer Research UK London Research Institute)
The role of FAPP, CERT and OSBP1 PI4P-binding proteins at the Golgi
Selected oral communication - Maria Antonella De Matteis (Consorzio Mario Negri Sud, Santa Italy)
Type I alpha inositol polyphosphate 4-phosphatase generates and terminates PI3-kinase signals on endosomes and the plasma membrane
Selected oral communication - Ivan Ivetac (Monash University, Australia )
18:30 - 20:00 Conference dinner
Phosphoinositide kinases and human disease
Lew Cantley (Harvard University, USA) (Harvard University, USA)
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