Meeting background

Our understanding of the role played by RNA molecules in the control of gene expression has evolved rapidly within recent years. Novel regulatory RNA elements have been identified in both eukaryota and prokaryota, including siRNAs, piRNAs, miRNAs, sRNAs, CRISPRs, riboswitches and RNA thermometers. These elements can fine tune mRNA metabolism according to the output of complex signalling networks or may provide simple on/off switches that respond to macroscopic changes in the cellular environment (e.g. temperature). They vary in size, in structure and in functional mechanism.

Although important differences exist in the RNA regulation of prokaryota and eukaryota, parallels are starting to emerge. The aim of this meeting is to provide a forum to discuss both parallels and differences, achieving a better understanding of the role of RNA in regulating gene expression.

The speakers of this Harden conference will discuss their work on RNA-based regulation in different organisms. Scientists in the audience, also working on a diverse range of systems, will take on the discussion in two poster sessions and informal events.